The role of dietary nitrate supplementation in neurovascular function
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Enhancing the nitrate-nitrite-NO pathway through dietary nitrate intake may help restore neurovascular function and support brain perfusion.
“Enhancing the nitrate-nitrite-NO pathway through dietary nitrate intake may therefore help to restore neurovascular function and support brain perfusion [170,171].”
From Dietary Nitrate-Rich Vegetables as Natural Modulators of Health: Mechanisms and Benefits in Ageing Populations (2026) · cites this paper as [171]
The paper’s discussion of NO and its Figure 1 caption describe dietary nitrate being reduced to nitrite and then NO, potentially benefiting neurovascular function. It also says supplementation may help maintain cerebral blood flow. But the Future directions section says whether it benefits people with cerebral vascular impairments remains to be investigated, so the claim that it may *restore* function goes beyond the evidence presented. (LLM, conf=0.82)
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Cites
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Nitrite as Regulator of Hypoxic Signaling in Mammalian Physiology
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Acute effect of a high nitrate diet on brain perfusion in older adults
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Reversal of neurovascular coupling in the default mode network: Evidence from hypoxia
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Self-citationRossetti, G. M. K., Macdonald, J. H., Wylie, L. J., Little, S. J., Newton, V., Wood, B., Hawkins, K. A., Beddoe, R., Davies, H. E., & Oliver, S. J. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00293.2017 · Cited by 30 · see citing works
Self-citationDietary nitrate supplementation enhances cerebrovascular CO2 reactivity in a sex-specific manner
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Impact of Dietary Nitrate Supplementation on Executive Function During Hypoxic Exercise
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Nitrate: “the source makes the poison”
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Dietary nitrate, aging and brain health: the latest evidence
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“Enhancing the nitrate-nitrite-NO pathway through dietary nitrate intake may therefore help to restore neurovascular function and support brain perfusion [170,171].”
Mohamed, R. S., Fouda, K. A., El‐Damhougy, S. T., & Hussein, M. M. (2026) · Letters in Applied NanoBioScience · doi:10.33263/lianbs152.066
- Authors
- Horiuchi, M., Rossetti, G. K., & Oliver, S.
- Affiliations
- Mount Fuji Research Institute (JP)
- Corresponding author
- Horiuchi, Masahiro
- ORCID
- Horiuchi, Masahiro
- Venue
- Neural Regeneration Research
- Published
- 2021
- Volume
- 16
- Issue
- 7
- Pages
- 1419
- ISSN
- 1673-5374 (ISSN-L)
- PMC
- PMC8284290
- OpenAlex
- W3113018387
- Cited by
- 5
- References
- 17
- Citations by year
- 2026: 2 · 2024: 1 · 2023: 1 · 2022: 1
- FWCI
- 0.30
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Neural Regeneration Research (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- CentAUR (University of Reading) (submittedVersion)
- Bangor University Research Portal (Bangor University) (submittedVersion, cc-by-nc-sa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Japan Society for the Promotion of Science (26440268, 19H04022)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- dietary nitrate, nitrate supplementation, nitric oxide, neurovascular function, cerebral blood flow, vasodilation
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