The DOI matches its Crossref record; 257 of the 257 references it cites were found in a registry or an index.
Glioblastoma multiforme: State of the art and future therapeutics
Open accessAbstract
BACKGROUND: Glioblastoma multiforme (GBM) is the most common and lethal primary malignancy of the central nervous system (CNS). Despite the proven benefit of surgical resection and aggressive treatment with chemo- and radiotherapy, the prognosis remains very poor. Recent advances of our understanding of the biology and pathophysiology of GBM have allowed the development of a wide array of novel therapeutic approaches, which have been developed. These novel approaches include molecularly targeted therapies, immunotherapies, and gene therapy. METHODS: We offer a brief review of the current standard of care, and a survey of novel therapeutic approaches for treatment of GBM. RESULTS: Despite promising results in preclinical trials, many of these therapies have demonstrated limited therapeutic efficacy in human clinical trials. Thus, although survival of patients with GBM continues to slowly improve, treatment of GBM remains extremely challenging. CONCLUSION: Continued research and development of targeted therapies, based on a detailed understanding of molecular pathogenesis can reasonably be expected to yield improved outcomes for patients with GBM.
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Metadata
- Authors
- Harter, D., Wilson, T., & Karajannis, M.
- Venue
- Surgical Neurology International
- Publisher
- Scientific Scholar
- Published
- 2014
- Volume
- 5
- Issue
- 1
- Pages
- 64
- ISSN
- 2152-7806 (ISSN-L)
- OpenAlex
- W2003438982
- Cited by
- 327
- References
- 257
- FWCI
- 12.60
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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