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Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial
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Radiotherapy Plus Concomitant and Adjuvant Temozolomide for Glioblastoma
Stupp, R., Mason, W. P., van den Bent, M. J., Weller, M., Fisher, B., Taphoorn, M. J. B., Belanger, K., Brandes, A. A., Marosi, C., Bogdahn, U., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043330 · Cited by 21,807
Self-citationStummer, W., Pichlmeier, U., Meinel, T., Wiestler, O. D., Zanella, F., & Reulen, H.-J. (2006) · The Lancet Oncology · doi:10.1016/s1470-2045(06)70665-9 · Cited by 3,423
Yung, W. K. A., Albright, R. E., Olson, J., Fredericks, R., Fink, K., Prados, M. D., Brada, M., Spence, A., Hohl, R. J., Shapiro, W., et al. (2000) · British Journal of Cancer · doi:10.1054/bjoc.2000.1316 · Cited by 929
Multicenter phase II trial of temozolomide in patients with glioblastoma multiforme at first relapse
Brada, M., Hoang-Xuan, K., Rampling, R., Dietrich, P.-Y., Dirix, L. Y., Macdonald, D., Heimans, J. J., Zonnenberg, B. A., Bravo-Marques, J. M., Henriksson, R., et al. (2001) · Annals of Oncology · doi:10.1023/a:1008382516636 · Cited by 372
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Research works printed but not linked: 46
- Walker, 1980, Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery, N Engl J Med, 303, 1323, 10.1056/NEJM198012043032303 · DOI · Paper page
- Laperriere, 2002, Radiotherapy for newly diagnosed malignant glioma in adults: a systematic review, Radiother Oncol, 64, 259, 10.1016/S0167-8140(02)00078-6 · DOI · Paper page
- Stewart, 2002, Chemotherapy in adult high-grade glioma: a systematic review and meta-analysis of individual patient data from 12 randomised trials, Lancet, 359, 1011, 10.1016/S0140-6736(02)08091-1 · DOI · Paper page
- Hegi, 2005, MGMT gene silencing and benefit from temozolomide in glioblastoma, N Engl J Med, 352, 997, 10.1056/NEJMoa043331 · DOI · Paper page
- Pocock, 1975, Sequential treatment assignment with balancing for prognostic factors in the controlled clinical trial, Biometrics, 31, 103, 10.2307/2529712 · DOI · Paper page
- Freedman, 1976, On the use of Pocock and Simon's method for balancing treatment numbers over prognostic factors in the controlled clinical trial, Biometrics, 32, 691, 10.2307/2529759 · DOI
- Ataman, 2004, Quality assurance of the EORTC 26981/22981; NCIC CE3 intergroup trial on radiotherapy with or without temozolomide for newly-diagnosed glioblastoma multiforme: the individual case review, Eur J Cancer, 40, 1724, 10.1016/j.ejca.2004.03.026 · DOI
- Taphoorn, 2005, Health-related quality of life in patients with glioblastoma: a randomised controlled trial, Lancet Oncol, 6, 937, 10.1016/S1470-2045(05)70432-0 · DOI · Paper page
- Mirimanoff, 2006, Radiotherapy and temozolomide for newly diagnosed glioblastoma: recursive partitioning analysis of the EORTC 26981/22981-NCIC CE3 phase III randomized trial, J Clin Oncol, 24, 2563, 10.1200/JCO.2005.04.5963 · DOI · Paper page
- Lamers, 2008, Cost-effectiveness of temozolomide for the treatment of newly diagnosed glioblastoma multiforme: a report from the EORTC 26981/22981 NCI-C CE3 Intergroup Study, Cancer, 112, 1337, 10.1002/cncr.23297 · DOI
- Gonzalez, 1994, Accelerated radiotherapy in glioblastoma multiforme: a dose searching prospective study, Radiother Oncol, 32, 98, 10.1016/0167-8140(94)90095-7 · doi:10.1016/0167-8140(94)90095-7
- Miralbell, 1999, Accelerated radiotherapy, carbogen, and nicotinamide in glioblastoma multiforme: report of European Organization for Research and Treatment of Cancer trial 22933, J Clin Oncol, 17, 3143, 10.1200/JCO.1999.17.10.3143 · doi:10.1200/jco.1999.17.10.3143
- Newlands, 1997, Temozolomide: a review of its discovery, chemical properties, pre-clinical development and clinical trials, Cancer Treat Rev, 23, 35, 10.1016/S0305-7372(97)90019-0 · DOI · Paper page
- Brock, 1998, Phase I trial of temozolomide using an extended continuous oral schedule, Cancer Res, 58, 4363
- Stupp, 2002, Promising survival for patients with newly diagnosed glioblastoma multiforme treated with concomitant radiation plus temozolomide followed by adjuvant temozolomide, J Clin Oncol, 20, 1375, 10.1200/JCO.2002.20.5.1375 · doi:10.1200/jco.2002.20.5.1375 · Paper page
- Wick, 2008, A novel tool to analyse MRI recurrence patterns in glioblastoma, Neuro Oncol, 10, 1019, 10.1215/15228517-2008-058 · DOI
- Brandes, 2008, MGMT promoter methylation status can predict the incidence and outcome of pseudoprogression after concomitant radiochemotherapy in newly diagnosed glioblastoma patients, J Clin Oncol, 26, 2192, 10.1200/JCO.2007.14.8163 · DOI · Paper page
- 2001, Randomized trial of procarbazine, lomustine and vincristine in the adjuvant treatment of high-grade astrocytoma: a Medical Research Council trial, J Clin Oncol, 19, 509, 10.1200/JCO.2001.19.2.509 · DOI · Paper page
- Wedge, 1997, In vitro evaluation of temozolomide combined with X-irradiation, Anticancer Drugs, 8, 92, 10.1097/00001813-199701000-00013 · DOI
- Hirose, 2001, p53 effects both the duration of G2/M arrest and the fate of temozolomide-treated human glioblastoma cells, Cancer Res, 61, 1957
- van Rijn, 2000, Survival of human glioma cells treated with various combination of temozolomide and X-rays, Int J Radiat Oncol Biol Phys, 47, 779, 10.1016/S0360-3016(99)00539-8 · DOI
- Wick, 2002, Prevention of irradiation-induced glioma cell invasion by temozolomide involves caspase 3 activity and cleavage of focal adhesion kinase, Cancer Res, 62, 1915
- Chakravarti, 2006, Temozolomide-mediated radiation enhancement in glioblastoma: a report on underlying mechanisms, Clin Cancer Res, 12, 4738, 10.1158/1078-0432.CCR-06-0596 · DOI · Paper page
- Curran, 1993, Recursive partitioning analysis of prognostic factors in three Radiation Therapy Oncology Group malignant glioma trials, J Natl Cancer Inst, 85, 704, 10.1093/jnci/85.9.704 · DOI · Paper page
- Behin, 2003, Primary brain tumours in adults, Lancet, 361, 323, 10.1016/S0140-6736(03)12328-8 · DOI · Paper page
- Gorlia, 2008, Nomograms for predicting survival of patients with newly diagnosed glioblastoma: prognostic factor analysis of EORTC and NCIC trial 26981-22981/CE.3, Lancet Oncol, 9, 29, 10.1016/S1470-2045(07)70384-4 · DOI · Paper page
- Schilsky, 2008, How not to treat cancer, Lancet Oncol, 9, 504, 10.1016/S1470-2045(08)70134-7 · doi:10.1016/s1470-2045(08)70134-7
- Gerson, 2002, Clinical relevance of MGMT in the treatment of cancer, J Clin Oncol, 20, 2388, 10.1200/JCO.2002.06.110 · DOI · Paper page
- Gerson, 2004, MGMT: its role in cancer aetiology and cancer therapeutics, Nat Rev Cancer, 4, 296, 10.1038/nrc1319 · DOI · Paper page
- Ochs, 2000, Apoptosis induced by DNA damage O6-methylguanine is Bcl-2 and caspase-9/3 regulated and Fas/caspase-8 independent, Cancer Res, 60, 5815
- Esteller, 2000, Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents, N Engl J Med, 343, 1350, 10.1056/NEJM200011093431901 · DOI · Paper page
- Hegi, 2004, Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide, Clin Cancer Res, 10, 1871, 10.1158/1078-0432.CCR-03-0384 · DOI · Paper page
- Jaeckle, 1998, Correlation of tumor O6 methylguanine-DNA methyltransferase levels with survival of malignant astrocytoma patients treated with bis-chloroethylnitrosourea: a Southwest Oncology Group study, J Clin Oncol, 16, 3310, 10.1200/JCO.1998.16.10.3310 · DOI · Paper page
- Criniere, 2007, MGMT prognostic impact on glioblastoma is dependent on therapeutic modalities, J Neurooncol, 83, 173, 10.1007/s11060-006-9320-0 · DOI
- Hegi, 2008, Correlation of O6-methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity, J Clin Oncol, 26, 4189, 10.1200/JCO.2007.11.5964 · DOI · Paper page
- Murat, 2008, Stem cell-related «self-renewal» signature and high epidermal growth factor receptor expression associated with resistance to concomitant chemoradiotherapy in glioblastoma, J Clin Oncol, 26, 3015, 10.1200/JCO.2007.15.7164 · DOI · Paper page
- Vredenburgh, 2007, Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma, Clin Cancer Res, 13, 1253, 10.1158/1078-0432.CCR-06-2309 · DOI · Paper page
- Batchelor, 2007, AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients, Cancer Cell, 11, 83, 10.1016/j.ccr.2006.11.021 · DOI · Paper page
- Kreisl, 2008, Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma, J Clin Oncol, 27, 740, 10.1200/JCO.2008.16.3055 · DOI · Paper page
- Stupp, 2007, Chemoradiotherapy in malignant glioma: standard of care and future directions, J Clin Oncol, 25, 4127, 10.1200/JCO.2007.11.8554 · DOI · Paper page
- Reardon, 2008, Randomized phase II study of cilengitide, an integrin-targeting arginine-glycine-aspartic acid peptide, in recurrent glioblastoma multiforme, J Clin Oncol, 26, 5610, 10.1200/JCO.2008.16.7510 · DOI · Paper page
- Reardon, 2008, Cilengitide: an integrin-targeting arginine-glycine-aspartic acid peptide with promising activity for glioblastoma multiforme, Expert Opin Investig Drugs, 17, 1225, 10.1517/13543784.17.8.1225 · DOI · Paper page
- Omuro, 2007, Lessons learned in the development of targeted therapy for malignant gliomas, Mol Cancer Ther, 6, 1909, 10.1158/1535-7163.MCT-07-0047 · DOI · Paper page
- Stupp, 2007, Phase I/IIa trial of cilengitide (EMD121974) and temozolomide with concomitant radiotherapy, followed by temozolomide and cilengitide maintenance therapy in patients with newly diagnosed glioblastoma, J Clin Oncol, 25, 75s
- Wen, 2008, Malignant gliomas in adults, N Engl J Med, 359, 492, 10.1056/NEJMra0708126 · DOI · Paper page
- van den Bent, 2009, Randomized phase II trial of erlotinib versus temozolomide or carmustine in recurrent glioblastoma, J Clin Oncol, 10.1200/JCO.2008.17.5984 · DOI · Paper page
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Cisplatin in cancer therapy: Molecular mechanisms of action
Dasari, S., & Bernard Tchounwou, P. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.07.025 · Cited by 5,537
Wen, P. Y., & Kesari, S. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0708126 · Cited by 3,511
A Randomized Trial of Bevacizumab for Newly Diagnosed Glioblastoma
Gilbert, M. R., Dignam, J. J., Armstrong, T. S., Wefel, J. S., Blumenthal, D. T., Vogelbaum, M. A., Colman, H., Chakravarti, A., Pugh, S., Won, M., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1308573 · Cited by 2,834
Stupp, R., Taillibert, S., Kanner, A., Read, W., Steinberg, D. M., Lhermitte, B., Toms, S., Idbaih, A., Ahluwalia, M. S., Fink, K., et al. (2017) · JAMA · doi:10.1001/jama.2017.18718 · Cited by 2,644
Self-citationCancer stem cells in glioblastoma
Lathia, J. D., Mack, S. C., Mulkearns-Hubert, E. E., Valentim, C. L. L., & Rich, J. N. (2015) · Genes & Development · doi:10.1101/gad.261982.115 · Cited by 1,520
Metadata
- Authors
- Stupp, R., Hegi, M. E., Mason, W. P., van den Bent, M. J., Taphoorn, M. J., Janzer, R. C., Ludwin, S. K., Allgeier, A., Fisher, B., Belanger, K., Hau, P., Brandes, A. A., Gijtenbeek, J., Marosi, C., Vecht, C. J., Mokhtari, K., Wesseling, P., Villa, S., Eisenhauer, E., Gorlia, T., Weller, M., Lacombe, D., Cairncross, J. G., & Mirimanoff, R.-O.
- Venue
- The Lancet Oncology
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 10
- Issue
- 5
- Pages
- 459-466
- ISSN
- 1470-2045 (ISSN-L)
- OpenAlex
- W2158681922
- Cited by
- 7,668
- References
- 4
- FWCI
- 127.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
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- CoChat. (2026). Citation check: Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. https://app.cochat.ai/papers/10.1016/s1470-2045(09)70025-7
- The paper
- Stupp, R., Hegi, M. E., Mason, W. P., van den Bent, M. J., Taphoorn, M. J., Janzer, R. C., Ludwin, S. K., Allgeier, A., Fisher, B., Belanger, K., Hau, P., Brandes, A. A., Gijtenbeek, J., Marosi, C., Vecht, C. J., Mokhtari, K., Wesseling, P., Villa, S., Eisenhauer, E., . . . Mirimanoff, R.-O. (2009). Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. The Lancet Oncology. https://doi.org/10.1016/s1470-2045(09)70025-7
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