Glucocorticoid-induced myopathy: pathophysiology, diagnosis, and treatment
Open accessAbstract
Glucocorticoid-induced myopathy is the most common type of drug-induced myopathy. Nearly 60% of patients with Cushing's syndrome have muscle weakness. Glucocorticoid-induced muscle atrophy affects mainly fast-twitch glycolytic muscle fibers (type IIb fibers). This brief review will discuss the pathophysiology behind glucocorticoid-induced myopathy, along with diagnostic features and treatment.
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More than half of patients with Cushing's syndrome can develop muscle weakness.
“More than half of patients with Cushing’s syndrome (from exogenous or endogenous glucocorticoid excess) can develop muscle weakness.100”
From Age-related and disease-related muscle loss: The effect of diabetes, obesity, and other diseases (2014) · cites this paper as [100]
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Glucocorticoids in Myositis: Initiation, Tapering, and Discontinuation
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- Authors
- Gupta, A., & Gupta, Y.
- Affiliations
- Government Medical College and Hospital (IN)
- Corresponding author
- Gupta, Yashdeep
- Venue
- Indian Journal of Endocrinology and Metabolism
- Published
- 2013-09
- Volume
- 17
- Issue
- 5
- Pages
- 913-916
- ISSN
- 2230-8210 (ISSN-L)
- 2230-9500
- PMC
- PMC3784879
- OpenAlex
- W2054338937
- Cited by
- 202
- References
- 19
- Citations by year
- 2026: 12 · 2025: 8 · 2024: 38 · 2023: 20 · 2022: 32 · 2021: 21 · 2020: 16 · 2019: 13 · 2018: 13 · 2017: 13 · 2016: 8 · 2015: 3 · 2014: 5
- FWCI
- 2.39
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Indian Journal of Endocrinology and Metabolism (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- glucocorticoid-induced myopathy, drug-induced myopathy, Cushing's syndrome, muscle weakness, muscle atrophy, fast-twitch muscle, type IIb muscle fibers, pathophysiology, diagnosis, treatment
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