Development of polyherbal antidiabetic formulation encapsulated in the phospholipids vesicle system
Open accessAbstract
Multifactorial metabolic diseases, for instance diabetes develop several complications like hyperlipidemia, hepatic toxicity, immunodeficiency etc., Hence, instead of mono-drug therapy the management of the disease requires the combination of herbs. Marketed herbal drugs comprise of irrational combinations, which makes their quality control more difficult. Phytoconstituents, despite having excellent bioactivity in vitro demonstrate less or no in vivo actions due to their poor lipid solubility, resulting in high therapeutic dose regimen; phospholipids encapsulation can overcome this problem. Hence, present study was designed to develop a phospholipids encapsulated polyherbal anti-diabetic formulation. In the present study, polyherbal formulation comprises of lyophilized hydro-alcoholic (50% v/v) extracts of Momordica charantia, Trigonella foenum-graecum and Withania somnifera 2:2:1, respectively, named HA, optimized based on oral glucose tolerance test model in normal Wistar rats. The optimized formulation (HA) entrapped in the phosphatidylcholine and cholesterol (8:2) vesicle system is named HA lipids (HAL). The vesicles were characterized for shape, morphology, entrapment efficiency, polar-dispersity index and release profile in the gastric pH. The antidiabetic potential of HA, marketed polyherbal formulation (D-fit) and HAL was compared in streptozotocin-induced diabetic rat model of 21 days study. The parameters evaluated were behavioral changes, body weight, serum glucose level, lipid profile and oxidative stress. The antidiabetic potential of HA (1000 mg/kg) was at par with the D-fit (1000 mg/kg). However, the potential was enhanced by phospholipids encapsulation; as HAL (500 mg/kg) has shown more significant (P < 0.05) potential in comparison to HA (1000 mg/kg) and at par with metformin (500 mg/kg).
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In a placebo-controlled study with WS extract, subtle changes in thyroid indices were noted in patients affected by bipolar disorder.
“Furthermore, in a placebo-controlled study with WS extract, subtle changes in thyroid indices were noted in patients affected by bipolar disorder.”
From Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects (2021) · cites this paper as [108]
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“Although several polyherbal formulations for diabetes management exist, their clinical efficacy and safety have not been proven clinically, raising concerns about quality control and potential adverse effects (Kalia and Gauttam 2013).”
Jatoth, R., Dhanabal, S., Venkatachalam, S., & Thangavel, M. G. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5340371
Hematoprotective Properties of Polyherbal Formulation on Streptozocin-Induced Diabetic Wistar Rats
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Exploring Novel Herbal Drug Delivery Technologies for better patient Outcomes
Mane, D. M., Tamboli, F. A., Mane, P. P., Attar, P. S., Tole, A. P., Disale, P. P., Parkhi, S. M., & A.Memon, D. S. (2026) · Research Journal of Pharmacy and Technology · doi:10.52711/0974-360x.2026.00319
Gupta, A., & Sharma, A. (2026) · International Journal of Research in Medical Sciences · doi:10.18203/2320-6012.ijrms20263142
A review on Herbal Anti-Diabetic Formulations and their Importance in Health Sector
Kumar, L. S., Ismail, B. B., Vaishnavi, L. B., Hanshika, K., & Divya, K. (2026) · Oriental Journal Of Chemistry · doi:10.13005/ojc/420402
Oyeleye, S. I., Ojo, O. R., Ademiluyi, A. O., Ogunsuyi, O. B., & Oboh, G. (2026) · Oriental Pharmacy and Experimental Medicine · doi:10.1007/s13596-026-00932-3
- Authors
- Kalia, A., & Gauttam, V.
- Venue
- Journal of Advanced Pharmaceutical Technology amp Research
- Published
- 2013
- Volume
- 4
- Issue
- 2
- Pages
- 108
- ISSN
- 0976-2094 (ISSN-L)
- 2231-4040
- PMC
- PMC3696222
- OpenAlex
- W2111284394
- Cited by
- 66
- References
- 2
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 9 · 2023: 11 · 2022: 4 · 2021: 5 · 2020: 11 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 1 · 2015: 2 · 2014: 1
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Journal of Advanced Pharmaceutical Technology amp Research (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Pharmacology and Nanomedicine Research
- Keywords
- polyherbal formulation, antidiabetic herbal medicine, phospholipid vesicles, phosphatidylcholine, cholesterol, Momordica charantia, fenugreek, Withania somnifera, encapsulation efficiency, oral glucose tolerance, streptozotocin-induced diabetes, oxidative stress, lipid profile, serum glucose, metformin comparison
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