Neuropharmacological classification of antidepressant agents based on their mechanisms of action
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Serotonin HT1b receptors on the presynaptic terminal also desensitize, further increasing presynaptic transmission and increasing serotonin available to stimulate postsynaptic neurons.
“Serotonin HT1b receptors on the presynaptic terminal then also desensitize, further increasing presynaptic transmission and increasing the serotonin available to stimulate postsynaptic neurons.”
From A Sequential Multiple Assignment Randomized Trial (SMART) study of medication and CBT sequencing in the treatment of pediatric anxiety disorders (2021) · cites this paper as [122]
Desensitization of presynaptic serotonin receptors increases impulse flow in the presynaptic neuron and ultimately increases serotonin concentrations in the synaptic cleft.
“Desensitization of these presynaptic serotonin receptors then increases impulse flow in the presynaptic neuron and ultimately increases serotonin concentrations in the synaptic cleft.”
From A Sequential Multiple Assignment Randomized Trial (SMART) study of medication and CBT sequencing in the treatment of pediatric anxiety disorders (2021) · cites this paper as [122]
SSRIs inhibit presynaptic reuptake of serotonin after its release into the synaptic cleft, which over time desensitizes HT1a serotonin receptors on or near the cell body of the presynaptic neuron.
“SSRIs inhibit the presynaptic reuptake of serotonin after its release into the synaptic cleft, which in turn, over time, desensitizes HT1a serotonin receptors on or near the cell body of the presynaptic neuron [122].”
From A Sequential Multiple Assignment Randomized Trial (SMART) study of medication and CBT sequencing in the treatment of pediatric anxiety disorders (2021) · cites this paper as [122]
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Maintenance Treatment of Major Depression in Old Age
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Peterson, B. S., West, A. E., Weisz, J. R., Mack, W. J., Kipke, M. D., Findling, R. L., Mittman, B. S., Bansal, R., Piantadosi, S., Takata, G., et al. (2021) · BMC Psychiatry · doi:10.1186/s12888-021-03314-y · Cited by 13 · see citing works
- Authors
- Fasipe, O.
- Venue
- Archives of Medicine and Health Sciences
- Published
- 2018
- Volume
- 6
- Issue
- 1
- Pages
- 81
- ISSN
- 2321-4848
- Cited by
- 67
- References
- 5
- Language
- en
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