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Cited by 431Treatment of Major DepressionMental Health Treatment and AccessAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Canadian Network for Mood and Anxiety Treatments (CANMAT) Clinical guidelines for the management of major depressive disorder in adults.

Lam, Raymond W., Kennedy, Sidney H., Grigoriadis, Sophie, McIntyre, Roger S., Milev, Roumen, Ramasubbu, Rajamannar, Parikh, Sagar V., Patten, Scott B. +1 more·2009·Journal of Affective Disorders
DOI 10.1016/j.jad.2009.06.041
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Abstract

Background In 2001, the Canadian Psychiatric Association and the Canadian Network for Mood and Anxiety Treatments (CANMAT) partnered to produce evidence-based clinical guidelines for the treatment of depressive disorders. A revision of these guidelines was undertaken by CANMAT in 2008-2009 to reflect advances in the field. Methods The CANMAT guidelines are based on a question-answer format to enhance accessibility to clinicians. An evidence-based format was used with updated systematic reviews of the literature and recommendations were graded according to Level of Evidence using pre-defined criteria. Lines of Treatment were identified based on criteria that included Levels of Evidence and expert clinical support. This section on "Pharmacotherapy" is one of 5 guideline articles. Results Despite emerging data on efficacy and tolerability differences amongst newer antidepressants, variability in patient response precludes identification of specific first choice medications for all patients. All second-generation antidepressants have Level 1 evidence to support efficacy and tolerability and most are considered first-line treatments for MDD. First-generation tricyclic and monoamine oxidase inhibitor antidepressants are not the focus of these guidelines but generally are considered second- or third-line treatments. For inadequate or incomplete response, there is Level 1 evidence for switching strategies and for add-on strategies including lithium and atypical antipsychotics. Limita…

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  • Earlier reviews and meta-analyses and recent treatment guidelines for long-term treatment of MDD are generally supportive of treatments continued for several months as well as more than a year, particularly pharmacotherapies.

    “Earlier reviews and meta-analyses and recent treatment guidelines for long-term treatment of MDD are generally supportive of treatments continued for several months as well as more than a year, particularly pharmacotherapies (Geddes et al., 2003; Lam et al., 2009; Pilling et al., 2009; Williams et al., 2009; Glue et al., 2010; Bauer et al., 2015).”

    From Prevention of Relapse and Recurrence in Adults with Major Depressive Disorder: Systematic Review and Meta-Analyses of Controlled Trials (2016) · cites this paper as Lam et al., 2009

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Authors
Lam, R. W., Kennedy, S. H., Grigoriadis, S., McIntyre, R. S., Milev, R., Ramasubbu, R., Parikh, S. V., Patten, S. B., & Ravindran, A. V.
Affiliations
  • University of British Columbia (CA)
  • University of Toronto (CA)
  • Queen's University (CA)
  • University of Calgary (CA)
Corresponding author
Lam, Raymond W.
ORCID
Venue
Journal of Affective Disorders
Publisher
Elsevier BV
Published
2009-10
Volume
117
Pages
S26-S43
ISSN
0165-0327 (ISSN-L)
DOI
10.1016/j.jad.2009.06.041
OpenAlex
W38793130
Cited by
431
References
150
Citations by year
2026: 6 · 2025: 4 · 2024: 8 · 2023: 9 · 2022: 13 · 2021: 15 · 2020: 16 · 2019: 18 · 2018: 24 · 2017: 27 · 2016: 41 · 2015: 55 · 2014: 43 · 2013: 49 · 2012: 55
FWCI
24.76
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Journal of Affective Disorders (publishedVersion)
  • PubMed (publishedVersion)
Funders
Canadian Network for Mood and Anxiety Treatments
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
major depressive disorder, antidepressant treatment, second-generation antidepressants, first-line therapy, inadequate response, switching strategy, adjunctive therapy, lithium, atypical antipsychotics, tricyclic antidepressants, monoamine oxidase inhibitors, treatment-resistant depression, adults
MeSH terms
Suicide Prevention, Adult, Antidepressive Agents, Depressive Disorder, Major, Major Depressive Disorder, Drug Interactions, Humans, Sexual Dysfunction, Physiological, Selective Serotonin Reuptake Inhibitors, Antidepressive Agents, Second-Generation

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