The DOI matches its Crossref record; 86 of the 86 references it cites were found in a registry or an index.
Efflux pump inhibitors for bacterial pathogens: From bench to bedside
Open accessAbstract
With the advent of antibiotics, bacterial infections were supposed to be a thing of past. However, this instead led to the selection and evolution of bacteria with mechanisms to counter the action of antibiotics. Antibiotic efflux is one of the major mechanisms, whereby bacteria pump out the antibiotics from their cellular interior to the external environment using special transporter proteins called efflux pumps. Inhibiting these pumps seems to be an attractive strategy at a time when novel antibiotic supplies are dwindling. Molecules capable of inhibiting these pumps, known as efflux pump inhibitors (EPIs), have been viewed as potential therapeutic agents that can rejuvenate the activity of antibiotics that are no longer effective against bacterial pathogens. EPIs follow some general mechanisms of efflux inhibition and are derived from various natural as well as synthetic sources. This review focuses on EPIs and identifies the challenges that have kept these futuristic therapeutics away from the commercial realm so far.
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Cites
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Cited by
Molecular mechanisms of antibiotic resistance revisited
Darby, E. M., Trampari, E., Siasat, P., Gaya, M. S., Alav, I., Webber, M. A., & Blair, J. M. A. (2023) · Nature Reviews Microbiology · doi:10.1038/s41579-022-00820-y · Cited by 1,398
Bacterial Resistance to Antimicrobial Agents
Varela, M. F., Stephen, J., Lekshmi, M., Ojha, M., Wenzel, N., Sanford, L. M., Hernandez, A. J., Parvathi, A., & Kumar, S. H. (2021) · Antibiotics · doi:10.3390/antibiotics10050593 · Cited by 292
Naik, G. A. R. R., Roy, A. A., Mutalik, S., & Dhas, N. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.134977 · Cited by 47
Nair, V. G., Unnikrishnan, V. K., Muralidharan, N., Venkatathri, B. N. S., Lowrence, R. C., YBRD, R., Narbhavi, D., A, A., N, P., & Nagarajan, S. (2025) · Scientific Reports · doi:10.1038/s41598-025-17404-4 · Cited by 8
Metadata
- Authors
- Sharma, A., Gupta, V. K., & Pathania, R.
- Venue
- Indian Journal of Medical Research
- Publisher
- Scientific Scholar
- Published
- 2019-02
- Volume
- 149
- Issue
- 2
- Pages
- 129-145
- ISSN
- 0971-5916 (ISSN-L)
- OpenAlex
- W2948713507
- Cited by
- 458
- References
- 86
- FWCI
- 9.79
- Type
- journal article
- Language
- en
- Open access
- diamond
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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