The DOI matches its Crossref record; 42 of the 43 references it cites were found in a registry or an index, and 1 are not checked yet.
Relationship between serum lipids and depression: A cross sectional survey among adults in Haryana, India
Open accessAbstract
ABSTRACT Introduction: Dyslipidemia and mental illnesses are significant contributors to the global noncommunicable disease burden and studies suggest an association between them. Aim: Using data from a noncommunicable disease risk factor survey conducted in Haryana, India, we undertook a secondary data analysis to examine the association between lipids and depressive symptoms. Methods: The survey involved 5,078 participants and followed the World Health Organisation STEPwise approach to NCD risk factor surveillance approach. Biochemical assessments were undertaken in a subset of participants. Lipid markers were measured using wet chemistry methods. Depressive symptoms were assessed using the Patient Health Questionnaire–9. Descriptive statistics were presented for all variables; logistic regression was used for association analyses. Results: The mean age of the study population was 38 years and 55% of them were females. A majority of the participants belonged to a rural background. The mean total cholesterol was 176 mg/dL and approximately 5% of the participants were found to have moderate to severe depression. The association of total cholesterol (odds ratio [OR] 0.99, P = 0.84), LDL-cholesterol (OR = 1.00, P = 0.19), HDL-cholesterol (OR = 0.99, P = .76), and triglycerides (OR 1.00, P = .12) with depressive symptoms was not significant. Conclusion: This study did not find any association between lipids and depressive symptoms. However, further investigations using prospective designs are warranted to understand this relationship and complex interactions with other mediating factors better.
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“Another research finding was that the level of lipids is not related to depressive symptoms in people [19], and also the association with suicidal behavior or attempts in patients with mental disorders is not clear [20,21].”
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Cites
The PHQ-9: Validity of a brief depression severity measure
Kroenke, K., Spitzer, R. L., & Williams, J. B. W. (2001) · Journal of General Internal Medicine · doi:10.1046/j.1525-1497.2001.016009606.x · Cited by 44,910 · cited 3×
“Although we used the PHQ-9 scale, which is a thoroughly validated and robust tool for the assessment of depressive symptoms worldwide, [26] the responses captured by this screening tool are self-reported and maybe subjective, which may have introduced a bias in our estimates.”
InfluentialGlobal Burden of Disease and the Impact of Mental and Addictive Disorders
Rehm, J., & Shield, K. D. (2019) · Current Psychiatry Reports · doi:10.1007/s11920-019-0997-0 · Cited by 1,388
Depression and cardiac mortality: results from a community-based longitudinal study.
Penninx, B., Beekman, A., Honig, A., Deeg, D., Schoevers, R., van Eijk, J., & van Tilburg, W. V. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.3.221 · Cited by 983 · cited 1×
“[41,42] Conversely, cardiac events and morbidity have also been shown to be determinants of acute and chronic depressive episodes in individuals.”
State of the art review: depression, stress, anxiety, and cardiovascular disease
Cohen, B. E., Edmondson, D., & Kronish, I. M. (2015) · American Journal of Hypertension · doi:10.1093/ajh/hpv047 · Cited by 955
The burden of non communicable diseases in developing countries
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“16] This has in-turn led to the creation of a five-by-five approach by the UN member states, focused on the inclusion of mental health in strategies to tackle the NCD burden.”
Depressive Symptoms and Risks of Coronary Heart Disease and Mortality in Elderly Americans
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“[41,42] Conversely, cardiac events and morbidity have also been shown to be determinants of acute and chronic depressive episodes in individuals.”
Anxiety and new onset of cardiovascular disease: critical review and meta-analysis
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Cited by
Sorted by citations
Liu, Y., Chen, M.-T., He, Y., Chen, M., Liang, J.-R., Jia, F., Huang, Q., Zhou, R., & Hou, C. (2024) · Lipids in Health and Disease · doi:10.1186/s12944-024-02285-9 · Cited by 18
“Studies involving other ethnic groups have yielded conclusions that diverge from those of the present study [67, 68].”
ResultLiu, Z., Sun, L., Sun, F., Zhang, Y., Wang, J., Zhang, Z., Sun, G., Sun, L., Yang, R., Yao, G., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e30344 · Cited by 17
“Another research finding was that the level of lipids is not related to depressive symptoms in people [19], and also the association with suicidal behavior or attempts in patients with mental disorders is not clear [20,21].”
BackgroundZeng, D., Zheng, Y., Zhao, X.-X., Li, S., Luo, L., Xie, W.-J., Zhang, P., Li, G.-J., He, S., Yu, Y.-M., et al. (2026) · Brain, behavior, and immunity · doi:10.1016/j.bbi.2026.106515 · Cited by 3
Zhang, Z., & Song, Y. (2024) · Medicine · doi:10.1097/md.0000000000038234 · Cited by 3
“[9] In a cross-sectional study of 40,904 Korean adults, it was discovered by scientists that depression symptoms are linked to either low or high levels of LDL-C.”
BackgroundKytikovа, O. Y., Antonyuk, M. V., Novgorodtseva, T. P., & Gvozdenko, T. A. (2024) · Russian Journal of Cardiology · doi:10.15829/1560-4071-2024-5945 · Cited by 3
Metadata
- Authors
- Mulchandani, R., Lyngdoh, T., Nangia, R., Singh, S., Grover, S., & Thakur, J.
- Affiliations
- Post Graduate Institute of Medical Education and Research (IN)
- Indian Council of Medical Research (IN)
- Department of Maharishi Markandeshwar Medical College and Hospital, Kumarhatti, Solan, Himachal Pradesh, India
- Department of Community Medicine and School of Public Heath, Chandigarh, India
- Venue
- Indian Journal of Psychiatry
- Published
- 2023-01
- Volume
- 65
- Issue
- 1
- Pages
- 61-67
- ISSN
- 0019-5545 (ISSN-L)
- 1998-3794
- PMC
- PMC9983447
- OpenAlex
- W4315643351
- Cited by
- 8
- References
- 42
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 5
- FWCI
- 2.14
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Indian Journal of Psychiatry (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Postgraduate Institute of Medical Education and Research, Chandigarh
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- serum lipids, depressive symptoms, dyslipidemia, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, non-communicable disease risk factors, Haryana
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- Mulchandani, R., Lyngdoh, T., Nangia, R., Singh, S., Grover, S., & Thakur, J. (2023). Relationship between serum lipids and depression: A cross sectional survey among adults in Haryana, India. Indian Journal of Psychiatry. https://doi.org/10.4103/indianjpsychiatry.indianjpsychiatry_967_21
