Comparison between baclofen and topiramate in alcohol dependence: A prospective study
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INTRODUCTION: Baclofen and topiramate are GABAergic drugs, and both have been recommended for the treatment of alcohol dependence as anticraving agent. Several studies have demonstrated the effect of baclofen and topiramate as anticraving, but none has compared them. The main aim of the current study was to assess the baclofen and topiramate as anticraving agent in alcohol dependence during 1 month follow-up. METHODOLOGY: = 45) for 1-month follow-up. Patients were assessed with clinical institute withdrawal assessment at baseline, and at 1 week, the Addiction Severity Index, ready to change questionnaire at baseline and weekly assessed with Obsessive and Compulsive drinking scale (OCDS) for craving. At every follow-up, adverse effects were also assessed to check tolerability. RESULTS: A marked improvement was observed with baclofen in OCDS in each assessment as compared to topiramate. With baclofen, 61.22% of patients became complete abstinence, as compared to 37.78% in topiramate group. Baclofen was better tolerated as 24.49% patients were dropped out in baclofen group as compared to 33.33% in topiramate group. CONCLUSION: Baclofen has better efficacy and tolerability as compared to topiramate.
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In a study comparing topiramate with baclofen, baclofen exhibited a significant improvement in obsessive and compulsive drinking scale scores compared to topiramate, with 61.22% achieving complete abstinence versus 37.78% in the topiramate group, and baclofen was better tolerated with a lower dropout rate (24.49% vs 33.33%).
“Baclofen exhibited a significant improvement in obsessive and compulsive drinking scale scores compared to topiramate, with 61.22% achieving complete abstinence versus 37.78% in the topiramate group. Baclofen was better tolerated, as indicated by a lower dropout rate (24.49%) compared to topiramate (33.33%) [64].”
From A Narrative Review of Current and Emerging Trends in the Treatment of Alcohol Use Disorder (2024) · cites this paper as [64]
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- Authors
- Kapoor, A., Jose, N., Yadav, P., & Mahla, V.
- Corresponding author
- Kapoor, Abhishek
- Venue
- Industrial Psychiatry Journal
- Published
- 2019
- Volume
- 28
- Issue
- 1
- Pages
- 44
- ISSN
- 0972-6748 (ISSN-L)
- PMC
- PMC6929233
- OpenAlex
- W2995287206
- Cited by
- 12
- References
- 26
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 2
- FWCI
- 0.76
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Industrial Psychiatry Journal (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Neurology › Alcoholism and Thiamine Deficiency
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- baclofen, topiramate, alcoholism, alcohol craving, GABAergic drugs, abstinence, tolerability, Addiction Severity Index
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