Methylglyoxal and insulin resistance in berberine-treated type 2 diabetic patients
Open accessAbstract
Background: Diabetes mellitus is a chronic metabolic disorder of hyperglycemia. Chronic hyperglycemia produces advanced glycation end products such as the methylglyoxal (MGO) which interferes with cell functions, insulin signaling, and β-cell functions. The present study was conducted to determine the effects of berberine (BBR) therapy on serum MGO and insulin resistance in newly diagnosed type 2 diabetic patients. Materials and Methods: The present case–control study was conducted at the Department of Medicine, Liaquat University of Medical and Health Sciences, Jamshoro/Hyderabad, from March 2016 to January 2017. A sample of 200 newly diagnosed type 2 diabetic patients was divided into two groups. Group 1 received metformin 500 mg (×3 daily) and Group 2 received BBR 500 mg (×3 daily) for 3 months. Blood samples were collected at baseline and after 3 months to analyze biochemical parameters on Roche biochemical analyzer. MGO was assayed by ELISA kit and homeostasis model assessment of insulin resistance (HOMA-IR) model. SPSS version 23.0 (IBM, Incorporation, USA) analyzed the data at 95% confidence interval (P ≤ 0.05). Results: Baseline HOMA-IR (% IR) and MGO were found elevated in metformin and BBR groups. After 3 months of metformin and BBR therapy, the HOMA-IR (% IR) and MGO were decreased to 3.69 ± 1.13 and 2.64 ± 0.76 and 35.84 ± 12.56 and 26.64 ± 10.73 ng/dl, respectively (P = 0.0001). HOMA-IR (% IR) was improved by 40% and 73% (P = 0.0001) and MGO by 43% and 56% in metformin and BBR groups, respectively (P = 0.0001). Conclusion: BBR is more effective in decreasing the serum MGO levels and insulin resistance through improved glycemic control in newly diagnosed type 2 diabetic patients.
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Systematic reviews showed that berberine improved obesity parameters including BMI.
“Systematic reviews showed that berberine improved obesity parameters including BMI [68, 69].”
From The Effect of Berberine on Metabolic Profiles in Type 2 Diabetic Patients: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials (2021) · cites this paper as [69]
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“, 2021) and alleviation of insulin resistance (Memon et al., 2018), especially in the treatment of combined multiple metabolic disorders, the efficacy of BBR is outstanding (Yu-Guang et al.”
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- Authors
- Memon, M., Khan, R., Riaz, S., Ain, Q., Ahmed, M., & Kumar, N.
- Affiliations
- Jinnah Postgraduate Medical Center (PK)
- Venue
- Journal of Research in Medical Sciences
- Published
- 2018
- Volume
- 23
- Issue
- 1
- Pages
- 110
- ISSN
- 1735-1995 (ISSN-L)
- PMC
- PMC6327683
- OpenAlex
- W2942888730
- Cited by
- 29
- References
- 22
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 6 · 2022: 5 · 2021: 3 · 2020: 6 · 2019: 2
- FWCI
- 1.77
- Type
- journal article
- Language
- en
- Update notices
- correction (2019-01-01)
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Journal of Research in Medical Sciences (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Pharmacology › Berberine and alkaloids research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Keywords
- methylglyoxal, insulin resistance, berberine, type 2 diabetes, metformin, advanced glycation end products, HOMA-IR, glycemic control, newly diagnosed diabetes
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