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Cited by 214Redox biology and oxidative stressT-cell and B-cell ImmunologyNeutrophil, Myeloperoxidase and Oxidative Mechanisms

The Role of Reactive Oxygen Species in Regulating T Cell-mediated Immunity and Disease

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Yarosz, Emily L., Chang, Cheong-Hee·2018·Immune Network
DOI 10.4110/in.2018.18.e14PMC PMC5833121
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Abstract

T lymphocytes rely on several metabolic processes to produce the high amounts of energy and metabolites needed to drive clonal expansion and the development of effector functions. However, many of these pathways result in the production of reactive oxygen species (ROS), which have canonically been thought of as cytotoxic agents due to their ability to damage DNA and other subcellular structures. Interestingly, ROS has recently emerged as a critical second messenger for T cell receptor signaling and T cell activation, but the sensitivity of different T cell subsets to ROS varies. Therefore, the tight regulation of ROS production by cellular antioxidant pathways is critical to maintaining proper signal transduction without compromising the integrity of the cell. This review intends to detail the common metabolic sources of intracellular ROS and the mechanisms by which ROS contributes to the development of T cell-mediated immunity. The regulation of ROS levels by the glutathione pathway and the Nrf2-Keap1-Cul3 trimeric complex will be discussed. Finally, T cell-mediated autoimmune diseases exacerbated by defects in ROS regulation will be further examined in order to identify potential therapeutic interventions for these disorders.

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Cited by

Sorted by citations

Authors
Yarosz, E. L., & Chang, C.-H.
Affiliations
University of Michigan (US)
Corresponding author
Chang, Cheong-Hee
ORCID
Venue
Immune Network
Publisher
XMLink
Published
2018
Volume
18
Issue
1
Pages
e14-e14
ISSN
  • 1598-2629 (ISSN-L)
  • 2092-6685
DOI
10.4110/in.2018.18.e14
PMC
PMC5833121
OpenAlex
W2791277314
Cited by
214
References
8
Citations by year
2026: 21 · 2025: 19 · 2024: 39 · 2023: 24 · 2022: 30 · 2021: 32 · 2020: 33 · 2019: 13 · 2018: 2 · 2017: 1
FWCI
1.96
Type
journal article
Language
en
Open access
Licence
Locations
  • Immune Network (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Funders
National Institutes of Health (AI121156, T32 AI007413)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Keywords
reactive oxygen species, T cell immunity, T cell activation, T cell receptor signaling, second messengers, T cell metabolism, glutathione pathway, antioxidant pathways, oxidative stress, autoimmune disease, T cell subsets

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