Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation

How mitochondria produce reactive oxygen species

Murphy, M. P. (2009) · Biochemical Journal · doi:10.1042/bj20081386 · Cited by 8,207 · see citing works

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

Zorov, D. B., Juhaszova, M., & Sollott, S. J. (2014) · Physiological Reviews · doi:10.1152/physrev.00026.2013 · Cited by 5,383 · see citing works

Anti-Vascular Endothelial Growth Factors Protect Retinal Pigment Epithelium Cells Against Oxidation by Modulating Nitric Oxide Release and Autophagy

Cillà, S. D., Farruggio, S., Vujosevic, S., Raina, G., Filippini, D. A., Gatti, V., Clemente, N., Mary, D., Vezzola, D., Casini, G., et al. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479441 · Cited by 5,154 · see citing works

Methods in Mammalian Autophagy Research

Mizushima, N., Yoshimori, T., & Levine, B. (2010) · Cell · doi:10.1016/j.cell.2010.01.028 · Cited by 4,497 · see citing works

mixOmics: An R package for ‘omics feature selection and multiple data integration

Rohart, F., Gautier, B., Singh, A., & Lê Cao, K.-A. (2017) · PLOS Computational Biology · doi:10.1371/journal.pcbi.1005752 · Cited by 4,056 · see citing works

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

Franceschi, C., & Campisi, J. (2014) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu057 · Cited by 3,891 · see citing works

Autophagy: cellular and molecular mechanisms

Glick, D. R., Barth, S., & Macleod, K. F. (2010) · The Journal of Pathology · doi:10.1002/path.2697 · Cited by 3,815 · see citing works

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

Geisler, S., Holmström, K. M., Skujat, D., Fiesel, F. C., Rothfuss, O. C., Kahle, P. J., & Springer, W. (2010) · Nature Cell Biology · doi:10.1038/ncb2012 · Cited by 2,835 · see citing works

Cepharanthine potently enhances the sensitivity of anticancer agents in K562 cells

Ikeda, R., Che, X., Yamaguchi, T., Ushiyama, M., Zheng, C., Okumura, H., Takeda, Y., Shibayama, Y., Nakamura, K. T., Jeung, H., et al. (2005) · Cancer Science · doi:10.1111/j.1349-7006.2005.00057.x · Cited by 2,268 · see citing works

The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation

Wang, R., Dillon, C. P., Shi, L. Z., Milasta, S., Carter, R., Finkelstein, D., McCormick, L. L., Fitzgerald, P., Chi, H., Munger, J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.021 · Cited by 2,140 · cited 9× · see citing works

Analysis of the Human Adult Urinary Metabolome Variations with Age, Body Mass Index, and Gender by Implementing a Comprehensive Workflow for Univariate and OPLS Statistical Analyses

Thévenot, E., Roux, A., Xu, Y., Ezan, É., & Junot, C. (2015) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5b00354 · Cited by 1,760 · see citing works

The mitochondrial basis of aging

Sun, N., Youle, R. J., & Finkel, T. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.01.028 · Cited by 1,441 · see citing works

LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation

Kabeya, Y., Mizushima, N., Yamamoto, A., Oshitani-Okamoto, S., Ohsumi, Y., & Yoshimori, T. (2004) · Journal of Cell Science · doi:10.1242/jcs.01131 · Cited by 1,394 · see citing works

Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells.

Yoshimori, T., Yamamoto, A., Moriyama, Y., Futai, M., & Tashiro, Y. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)47429-2 · Cited by 1,334 · see citing works

Generation of reactive oxygen species by the mitochondrial electron transport chain

Liu, Y., Fiskum, G., & Schubert, D. (2002) · Journal of Neurochemistry · doi:10.1046/j.0022-3042.2002.00744.x · Cited by 1,260 · see citing works

Inflammaging and ‘Garb-aging’

Franceschi, C., Garagnani, P., Vitale, G., Capri, M., & Salvioli, S. (2017) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2016.09.005 · Cited by 997 · see citing works

Glucose Metabolism Regulates T Cell Activation, Differentiation, and Functions

Palmer, C. S., Ostrowski, M., Balderson, B., Christian, N., & Crowe, S. M. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00001 · Cited by 992 · see citing works

Double-check: validation of diagnostic statistics for PLS-DA models in metabolomics studies

Szymańska, E., Saccenti, E., Smilde, A. K., & Westerhuis, J. A. (2011) · Metabolomics · doi:10.1007/s11306-011-0330-3 · Cited by 913 · see citing works

The origins of age-related proinflammatory state

Ferrucci, L., Corsi, A., Lauretani, F., Bandinelli, S., Bartali, B., Taub, D. D., Guralnik, J. M., & Longo, D. L. (2005) · Blood · doi:10.1182/blood-2004-07-2599 · Cited by 908 · see citing works

Mitochondria and Mitophagy

Kubli, D. A., & Gustafsson, Å. B. (2012) · Circulation Research · doi:10.1161/circresaha.112.265819 · Cited by 792 · see citing works

Mitochondrial Fission Inhibitors Suppress Endothelin-1-Induced Artery Constriction

Chen, C., Gao, J., Liu, M., Li, S., Xuan, X., Zhang, X., Zhang, X.-Y., Wei, Y., Zhen, C., Jin, J., et al. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479536 · Cited by 782 · see citing works

Therapeutic Targeting of Mitochondrial Superoxide in Hypertension

Dikalova, A., Bikineyeva, A. T., Budzyn, K., Nazarewicz, R. R., McCann, L. A., Lewis, W., Harrison, D. G., & Dikalov, S. (2010) · Circulation Research · doi:10.1161/circresaha.109.214601 · Cited by 737 · see citing works

Upregulated NLRP3 Inflammasome Activation in Patients With Type 2 Diabetes

Lee, H., Kim, J.-J., Kim, H. J., Shong, M., Ku, B. J., & Jo, E. (2012) · Diabetes · doi:10.2337/db12-0420 · Cited by 730 · see citing works

Mitochondrial STAT3 Supports Ras-Dependent Oncogenic Transformation

Gough, D. J., Corlett, A., Schlessinger, K., Wegrzyn, J., Larner, A. C., & Levy, D. E. (2009) · Science · doi:10.1126/science.1171721 · Cited by 716 · see citing works

Anti-inflammatory effects of metformin irrespective of diabetes status

Cameron, A. R., Morrison, V. L., Levin, D., Mohan, M., Forteath, C., Beall, C., McNeilly, A. D., Balfour, D. J. K., Savinko, T., Wong, A. K. F., et al. (2016) · Circulation Research · doi:10.1161/circresaha.116.308445 · Cited by 704 · see citing works

IL-21 Is Produced by Th17 Cells and Drives IL-17 Production in a STAT3-dependent Manner

Wei, L., Laurence, A. D. J., Elias, K. M., & O’Shea, J. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705100200 · Cited by 639 · see citing works

Automated optimized parameters for T-distributed stochastic neighbor embedding improve visualization and analysis of large datasets

Belkina, A. C., Ciccolella, C. O., Anno, R., Halpert, R., Špidlen, J., & Snyder-Cappione, J. E. (2019) · Nature Communications · doi:10.1038/s41467-019-13055-y · Cited by 624 · see citing works

Comparison of the variable importance in projection (VIP) and of the selectivity ratio (SR) methods for variable selection and interpretation

Farrés, M., Platikanov, S., Tsakovski, S. L., & Tauler, R. (2015) · Journal of Chemometrics · doi:10.1002/cem.2736 · Cited by 610 · see citing works

Activation of the JAK-STAT pathway by reactive oxygen species

Simon, A. R., Rai, U., Fanburg, B. L., & Cochran, B. (1998) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1998.275.6.c1640 · Cited by 600 · see citing works

Glucose Intolerance and Aging: Evidence for Tissue Insensitivity to Insulin

DeFronzo, R. A. (1979) · Diabetes · doi:10.2337/diab.28.12.1095 · Cited by 595 · see citing works

The role of STAT3 in autophagy

You, L., Wang, Z., Li, H., Shou, J., Jing, Z., Xie, J., Sui, X., Pan, H., & Han, W. (2015) · Autophagy · doi:10.1080/15548627.2015.1017192 · Cited by 515 · see citing works

A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring

Alpert, A., Pickman, Y., Leipold, M., Rosenberg-Hasson, Y., Ji, X., Gaujoux, R., Rabani, H., Starosvetsky, E., Kveler, K., Schaffert, S., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0381-y · Cited by 513 · see citing works

Glutathione primes t cell metabolism for inflammation

Mak, T. W., Grusdat, M., Duncan, G. S., Dostert, C., Nonnenmacher, Y., Cox, M., Binsfeld, C., Hao, Z., Brüstle, A., Itsumi, M., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.03.019 · Cited by 511 · see citing works

Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions

Menk, A. V., Scharping, N. E., Moreci, R. S., Zeng, X., Guy, C. S., Salvatore, S. R., Bae, H. R., Xie, J., Young, H. A., Wendell, S. G., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.01.040 · Cited by 478 · see citing works

Metabolic pathways in T cell activation and lineage differentiation

Almeida, L., Lochner, M., Berod, L., & Sparwasser, T. D. (2016) · Seminars in Immunology · doi:10.1016/j.smim.2016.10.009 · Cited by 475 · see citing works

Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis

Wei, J., Long, L., Yang, K., Guy, C., Shrestha, S., Chen, Z., Wu, C., Vogel, P., Neale, G., Green, D. R., et al. (2016) · Nature Immunology · doi:10.1038/ni.3365 · Cited by 470 · see citing works

Metformin and inflammation: its potential Beyond glucose-lowering effect

Saisho, Y. (2015) · Endocrine, Metabolic & Immune Disorders-Drug Targets · doi:10.2174/1871530315666150316124019 · Cited by 450 · see citing works

Monocyte Cytokine Production in an Elderly Population: Effect of Age and Inflammation

Roubenoff, R., Harris, T. B., Abad, L. W., Wilson, P. W. F., Dallal, G. E., & Dinarello, C. A. (1998) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/53a.1.m20 · Cited by 418 · see citing works

Metabolic Shifts in Immunity and Inflammation

Kominsky, D. J., Campbell, E. L., & Colgan, S. P. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903002 · Cited by 413 · see citing works

The effect of aging on carbohydrate metabolism: a review of the English literature and a practical approach to the diagnosis of diabetes mellitus in the elderly

Davidson, M. B. (1979) · Metabolism · doi:10.1016/0026-0495(79)90024-6 · Cited by 411 · see citing works

Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants

Rosa, V. D., Galgani, M., Porcellini, A., Colamatteo, A., Santopaolo, M., Zuchegna, C., Romano, A., Simone, S. D., Procaccini, C., Rocca, C. L., et al. (2015) · Nature Immunology · doi:10.1038/ni.3269 · Cited by 397 · see citing works

Reversal of Mitochondrial Transhydrogenase Causes Oxidative Stress in Heart Failure

Nickel, A. G., von Hardenberg, A., Hohl, M., Löffler, J., Kohlhaas, M., Becker, J., Reil, J., Kazakov, A., Bonnekoh, J., Stadelmaier, M., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.07.008 · Cited by 380 · see citing works

Pathogenesis of Age-Related Glucose Intolerance in Man: Insulin Resistance and Decreased β-Cell Function*

CHEN, M., BERGMAN, R. N., PACINI, G., & PORTE, D. (1985) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-60-1-13 · Cited by 353 · see citing works

Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells

Ungvari, Z. I., Labinskyy, N., Mukhopadhyay, P., Pinto, J. T., Bagi, Z. A., Ballabh, P., Zhang, C., Pacher, P., & Csiszár, A. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00375.2009 · Cited by 343 · see citing works

Glucose is essential for proliferation and the glycolytic enzyme induction that provokes a transition to glycolytic energy production.

Greiner, E. F., Guppy, M., & Brand, K. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)31720-4 · Cited by 307 · see citing works

Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster

Rana, A., Oliveira, M. P., Khamoui, A. V., Aparicio, R., Rera, M., Rossiter, H. B., & Walker, D. W. (2017) · Nature Communications · doi:10.1038/s41467-017-00525-4 · Cited by 294 · see citing works

Human Aging and Longevity Are Characterized by High Levels of Mitokines

Conte, M., Ostan, R., Fabbri, C., Santoro, A., Guidarelli, G., Vitale, G., Mari, D., Sevini, F., Capri, M., Sandri, M., et al. (2019) · The Journals of Gerontology: Series A · doi:10.1093/gerona/gly153 · Cited by 219 · see citing works

Effect of metformin on oxidative stress, nitrosative stress and inflammatory biomarkers in type 2 diabetes patients

Chakraborty, A., Chowdhury, S., & Bhattacharyya, M. (2010) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2010.11.030 · Cited by 215 · see citing works

The Role of Reactive Oxygen Species in Regulating T Cell-mediated Immunity and Disease

Yarosz, E. L., & Chang, C.-H. (2018) · Immune Network · doi:10.4110/in.2018.18.e14 · Cited by 214 · see citing works

Autophagosome-Lysosome Fusion Depends on the pH in Acidic Compartments in CHO Cells

Kawai, A., Uchiyama, H., Takano, S., Nakamura, N., & Ohkuma, S. (2007) · Autophagy · doi:10.4161/auto.3634 · Cited by 205 · see citing works

The autophagy gene Atg16l1 differentially regulates Treg and TH2 cells to control intestinal inflammation

Kabat, A. M., Harrison, O. J., Riffelmacher, T., Moghaddam, A. E., Pearson, C. F., Laing, A., Abeler-Dörner, L., Forman, S. P., Grencis, R. K., Sattentau, Q., et al. (2016) · eLife · doi:10.7554/elife.12444 · Cited by 193 · see citing works

Evolutionary theory predicts late-life mortality plateaus

Mueller, L. D., & Rose, M. R. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.26.15249 · Cited by 190 · see citing works

Smooth-muscle BMAL1 participates in blood pressure circadian rhythm regulation

Xie, Z., Su, W., Liu, S., Zhao, G., Esser, K., Schroder, E. A., Lefta, M., Stauss, H. M., Guo, Z., & Gong, M. C. (2015) · Journal of Clinical Investigation · doi:10.1172/jci76881 · Cited by 189 · see citing works

Measuring Bioenergetics in T Cells Using a Seahorse Extracellular Flux Analyzer

van der Windt, G. J. W., Chang, C., & Pearce, E. L. (2016) · Current Protocols in Immunology · doi:10.1002/0471142735.im0316bs113 · Cited by 186 · see citing works

IL ‐17: overview and role in oral immunity and microbiome

Abusleme, L., & Moutsopoulos, N. M. (2016) · Oral Diseases · doi:10.1111/odi.12598 · Cited by 185 · see citing works

Autophagy and Aging

Martínez-López, N., Athonvarangkul, D., & Singh, R. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-2404-2_3 · Cited by 183 · see citing works

Mitochondrial degradation and energy metabolism

Melser, S., Lavie, J., & Bénard, G. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.05.010 · Cited by 163 · see citing works

Fatty Acid Metabolites Combine with Reduced β Oxidation to Activate Th17 Inflammation in Human Type 2 Diabetes

Nicholas, D., Proctor, E. A., Agrawal, M., Belkina, A. C., Nostrand, S. C. V., Bharath, L. P., Jones, A. R., Raval, F., Ip, B. C., Zhu, M., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.07.004 · Cited by 154 · see citing works

Cholesterol-dependent clustering of IL-2Rα and its colocalization with HLA and CD48 on T lymphoma cells suggest their functional association with lipid rafts

Vereb, G., Matkó, J., Vámosi, G., Ibrahim, S., Magyar, E., Varga, S., Szöllõsi, J., Jenei, A., Gáspár, R., Waldmann, T. A., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.11.6013 · Cited by 152 · see citing works

STAT3-Mediated Metabolic Reprograming in Cellular Transformation and Implications for Drug Resistance

Poli, V., & Camporeale, A. (2015) · Frontiers in Oncology · doi:10.3389/fonc.2015.00121 · Cited by 135 · see citing works

Impairment of autophagy in endothelial cells prevents shear-stress-induced increases in nitric oxide bioavailability

Bharath, L. P., Mueller, R., Li, Y., Ruan, T., Kunz, D., Goodrich, R., Mills, T. J., Deeter, L., Sargsyan, A., Babu, P. V. A., et al. (2014) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2014-0017 · Cited by 128 · see citing works

Th17 cytokines differentiate obesity from obesity‐associated type 2 diabetes and promote TNF α production

Ip, B. C., Cilfone, N. A., Belkina, A. C., DeFuria, J., Jagannathan‐Bogdan, M., Zhu, M., Kuchibhatla, R., McDonnell, M. E., Xiao, Q., Kepler, T. B., et al. (2015) · Obesity · doi:10.1002/oby.21243 · Cited by 128 · see citing works

Ceramide-Initiated Protein Phosphatase 2A Activation Contributes to Arterial Dysfunction In Vivo

Bharath, L. P., Ruan, T., Li, Y., Ravindran, A., Wan, X., Nhan, J. K., Walker, M., Deeter, L., Goodrich, R., Johnson, E., et al. (2015) · Diabetes · doi:10.2337/db15-0244 · Cited by 127 · see citing works

New insights into the roles of Stat5a/b and Stat3 in T cell development and differentiation

Wei, L., Laurence, A. D. J., & O’Shea, J. J. (2008) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2008.07.011 · Cited by 120 · see citing works

Glutathione Primes T Cell Metabolism for Inflammation

Mak, T. W., Grusdat, M., Duncan, G. S., Dostert, C., Nonnenmacher, Y., Cox, M. A., Binsfeld, C., Hao, Z., Brüstle, A., Itsumi, M., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.06.009 · Cited by 118 · see citing works

Age-associated changes in human CD4+ T cells point to mitochondrial dysfunction consequent to impaired autophagy

Bektas, A., Schurman, S. H., Gonzalez-Freire, M., Dunn, C. A., Singh, A. K., Macian, F., Cuervo, A. M., Sen, R., & Ferrucci, L. (2019) · Aging · doi:10.18632/aging.102438 · Cited by 116 · see citing works

Cytobank: Providing an Analytics Platform for Community Cytometry Data Analysis and Collaboration

Chen, T. J., & Kotecha, N. (2014) · Current topics in microbiology and immunology · doi:10.1007/82_2014_364 · Cited by 108 · see citing works

Stat3 Phosphorylation Mediates Resistance of Primary Human T Cells to Regulatory T Cell Suppression

Goodman, W. A., Young, A. B., McCormick, T. S., Cooper, K. D., & Levine, A. D. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1001455 · Cited by 104 · see citing works

The effects of rosiglitazone and metformin on inflammation and endothelial dysfunction in patients with type 2 diabetes mellitus

Fidan, E., Ersöz, H. Ö., Yılmaz, M., Yilmaz, H., Koçak, M., Karahan, C., & Erem, C. (2011) · Acta Diabetologica · doi:10.1007/s00592-011-0276-y · Cited by 102 · see citing works

Role of Dynamin-Related Protein 1 (Drp1)-Mediated Mitochondrial Fission in Oxygen Sensing and Constriction of the Ductus Arteriosus

Hong, Z., Kutty, S., Tóth, P. T., Marsboom, G., Hammel, J. M., Chamberlain, C., Ryan, J. J., Zhang, H. J., Sharp, W. W., Morrow, E., et al. (2013) · Circulation Research · doi:10.1161/circresaha.111.300285 · Cited by 99 · see citing works

Endothelial Cell Autophagy Maintains Shear Stress–Induced Nitric Oxide Generation via Glycolysis-Dependent Purinergic Signaling to Endothelial Nitric Oxide Synthase

Bharath, L. P., Cho, J. M., Park, S.-K., Ruan, T., Li, Y., Mueller, R., Bean, T., Reese, V. R., Richardson, R. S., Cai, J., et al. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.309510 · Cited by 96 · see citing works

Enhanced Th17 Differentiation and Aggravated Arthritis in IEX-1–Deficient Mice by Mitochondrial Reactive Oxygen Species-Mediated Signaling

Liang, Z., Ustyugova, I. V., Chen, X., Zhang, Q., & Wu, M. X. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200528 · Cited by 84 · see citing works

Advances in the quantification of mitochondrial function in primary human immune cells through extracellular flux analysis

Nicholas, D., Proctor, E. A., Raval, F., Ip, B. C., Habib, C., Ritou, E., Grammatopoulos, T. N., Steenkamp, D., Dooms, H., Apovian, C. M., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170975 · Cited by 77 · see citing works

Prohibitin 1 Modulates Mitochondrial Stress-Related Autophagy in Human Colonic Epithelial Cells

Kathiria, A. S., Butcher, L. D., Feagins, L. A., Souza, R. F., Boland, C. R., & Theiss, A. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031231 · Cited by 73 · see citing works

Cutting Edge: TGF-β and Phosphatidylinositol 3-Kinase Signals Modulate Distinct Metabolism of Regulatory T Cell Subsets

Priyadharshini, B., Loschi, M. L., Newton, R. H., Zhang, J.-W., Finn, K. K., Gerriets, V. A., Huynh, A., Rathmell, J. C., Blazar, B. R., & Turka, L. A. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1800311 · Cited by 73 · see citing works

Humanins, the neuroprotective and cytoprotective peptides with antiapoptotic and anti-inflammatory properties

Zapała, B., Kaczyński, Ł., Kieć‐Wilk, B., Staszel, T., Knapp, A., Thoresen, G. H., Wybrańska, I., & Dembinska-Kiec, A. (2010) · Pharmacological Reports · doi:10.1016/s1734-1140(10)70337-6 · Cited by 70 · see citing works

Age Associated Oxidative Damage in Lymphocytes

Gautam, N., Das, S., Mahapatra, S. K., Chakraborty, S. P., Kundu, P. K., & Roy, S. (2010) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.3.4.12860 · Cited by 67 · see citing works

Inflammaging: Age and Systemic, Cellular, and Nuclear Inflammatory Biology in Older Adults

Piber, D., Olmstead, R., Cho, J. H.-J., Witarama, T., Perez, C., Dietz, N., Seeman, T. E., Breen, E. C., Cole, S. W., & Irwin, M. R. (2019) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glz130 · Cited by 62 · see citing works

Autophagy-dependent regulatory T cells are critical for the control of graft-versus-host disease

Texier, L. L., Lineburg, K. E., Cao, B., McDonald-Hyman, C. S., Leveque, L., Nicholls, J., Melino, M., Nalkurthi, B. C., Alexander, K. A., Teal, B. E., et al. (2016) · JCI Insight · doi:10.1172/jci.insight.86850 · Cited by 58 · see citing works

A New Perspective: Mitochondrial Stat3 as a Regulator for Lymphocyte Function

Rincón, M., & Pereira, F. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061656 · Cited by 51 · see citing works

TNF-α, leptin, and lymphocyte function in human aging

Brüünsgaard, H., Pedersen, B. K., Schroll, M., Skinhøj, P., & Pedersen, B. K. (2000) · Life Sciences · doi:10.1016/s0024-3205(00)00851-1 · Cited by 50 · see citing works

YFP photoconversion revisited: confirmation of the CFP-like species

Kirber, M. T., Chen, K., & Keaney, J. F. (2007) · Nature Methods · doi:10.1038/nmeth1007-767 · Cited by 49 · see citing works

Insulin resistance in African-American and Caucasian women: differences in lipotoxicity, adipokines, and gene expression in adipose tissue and muscle.

Smith, L., Yao-Borengasser, A., Starks, T., Tripputi, M., Kern, P., & Rasouli, N. (2010) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jc.2010-0017 · Cited by 47 · see citing works

Lipopolysaccharide (LPS)-induced autophagy is involved in the restriction of Escherichia coliin peritoneal mesothelial cells

Wang, J., Feng, X., Zeng, Y., Fan, J., Wu, J., Li, Z., Liu, X., Huang, R., Huang, F., Yu, X., et al. (2013) · BMC Microbiology · doi:10.1186/1471-2180-13-255 · Cited by 35 · see citing works

Mediator of ERBB2-driven Cell Motility (MEMO) Promotes Extranuclear Estrogen Receptor Signaling Involving the Growth Factor Receptors IGF1R and ERBB2*

Jiang, K., Yang, Z., Cheng, L., Wang, S., Ning, K., Zhou, L., Lin, J., Zhong, H., Wang, L., Yang, L., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.467837 · Cited by 29 · see citing works

Effects of Metformin on Tissue Oxidative and Dicarbonyl Stress in Transgenic Spontaneously Hypertensive Rats Expressing Human C-Reactive Protein

Malínská, H., Oliyarnyk, O., Škop, V., Šilhavý, J., Landa, V., Zı́dek, V., Mlejnek, P., Šimáková, M., Strnad, H., Kazdová, L., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0150924 · Cited by 22 · see citing works

The effect of aging on the autophagic and heat shock response in human peripheral blood mononuclear cells

McCormick, J., VanDusseldorp, T., Ulrich, C., Lanphere, R., Dokładny, K., Mosely, P., & Mermier, C. (2018) · Physiology International · doi:10.1556/2060.105.2018.3.20 · Cited by 19 · see citing works

Adaptive Immunity and Metabolic Health: Harmony Becomes Dissonant in Obesity and Aging

Bharath, L. P., Ip, B. C., & Nikolajczyk, B. S. (2017) · Comprehensive physiology · doi:10.1002/cphy.c160042 · Cited by 17 · see citing works

Tyrosine 705 Phosphorylation of STAT3 Is Associated with Phenotype Severity in TGFβ1 Transgenic Mice

Guadagnin, E., Narola, J., Bonnemann, C., & Chen, Y.-W. (2015) · BioMed Research International · doi:10.1155/2015/843743 · Cited by 16 · see citing works

Author Correction: Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo

Madiraju, A. K., Qiu, Y., Perry, R. J., Rahimi, Y., Zhang, X., Zhang, D., Camporez, J. P., Cline, G. W., Butrico, G. M., Kemp, B. E., et al. (2019) · Nature Medicine · doi:10.1038/s41591-018-0220-6 · Cited by 2 · see citing works

Aging and aging-related diseases: from molecular mechanisms to interventions and treatments

Guo, J., Huang, X., Dou, L., Yan, M., Shen, T., Tang, W., & Li, J. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01251-0 · Cited by 1,834 · see citing works

Mitochondrial and metabolic dysfunction in ageing and age-related diseases

Amorim, J. A., Coppotelli, G., Rolo, A. P., Palmeira, C. M., Ross, J. M., & Sinclair, D. A. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00626-7 · Cited by 990 · see citing works

Cellular and Molecular Mechanisms of Metformin Action

LaMoia, T. E., & Shulman, G. I. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnaa023 · Cited by 791 · see citing works

Metformin: update on mechanisms of action and repurposing potential

Foretz, M., Guigas, B., & Viollet, B. (2023) · Nature Reviews Endocrinology · doi:10.1038/s41574-023-00833-4 · Cited by 744 · see citing works

Hallmarks of T cell aging

Mittelbrunn, M., & Kroemer, G. (2021) · Nature Immunology · doi:10.1038/s41590-021-00927-z · Cited by 702 · see citing works

Strategies for targeting senescent cells in human disease

Gasek, N. S., Kuchel, G. A., Kirkland, J. L., & Xu, M. (2021) · Nature Aging · doi:10.1038/s43587-021-00121-8 · Cited by 501 · see citing works

Chronic inflammation and the hallmarks of aging

Baechle, J. J., Chen, N., Makhijani, P., Winer, S., Furman, D., & Winer, D. A. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101755 · Cited by 471 · see citing works

SARS-CoV-2, COVID-19 and the aging immune system

Bartleson, J. M., Radenkovic, D., Covarrubias, A. J., Furman, D., Winer, D. A., & Verdin, E. (2021) · Nature Aging · doi:10.1038/s43587-021-00114-7 · Cited by 359 · see citing works

A druggable copper-signalling pathway that drives inflammation

Solier, S., Müller, S., Cañeque, T., Versini, A., Mansart, A., Sindikubwabo, F., Baron, L., Emam, L., Gestraud, P., Pantoş, G. D., et al. (2023) · Nature · doi:10.1038/s41586-023-06017-4 · Cited by 344 · see citing works

Neuroinflammation in Alzheimer’s Disease

Onyango, I. G., Jauregui, G. V., Čarná, M., Bennett, J. P., & Stokin, G. B. (2021) · Biomedicines · doi:10.3390/biomedicines9050524 · Cited by 330 · see citing works

Astrocytes as Key Regulators of Brain Energy Metabolism: New Therapeutic Perspectives

Béard, E., Lengacher, S., Dias, S., Magistretti, P. J., & Finsterwald, C. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2021.825816 · Cited by 309 · see citing works

Interconnections between Inflammageing and Immunosenescence during Ageing

Teissier, T., Boulanger, É., & Cox, L. S. (2022) · Cells · doi:10.3390/cells11030359 · Cited by 310 · see citing works

Inflammation: the incubator of the tumor microenvironment

Denk, D., & Greten, F. R. (2022) · Trends in cancer · doi:10.1016/j.trecan.2022.07.002 · Cited by 279 · see citing works

Association between Systemic Immunity-Inflammation Index and Hyperlipidemia: A Population-Based Study from the NHANES (2015–2020)

Mahemuti, N., Jing, X., Zhang, N., Liu, C., Li, C., Cui, Z., Liu, Y., & Chen, J. (2023) · Nutrients · doi:10.3390/nu15051177 · Cited by 260 · see citing works

Human trials exploring anti-aging medicines

Guarente, L., Sinclair, D. A., & Kroemer, G. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2023.12.007 · Cited by 257 · see citing works

Microenvironment responsive nanocomposite hydrogel with NIR photothermal therapy, vascularization and anti-inflammation for diabetic infected wound healing

Zhu, S., Zhao, B., Li, M., Wang, H., Zhu, J., Li, Q., Gao, H., Feng, Q., & Cao, X. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.03.005 · Cited by 254 · see citing works

Mitophagy in Alzheimer’s disease: Molecular defects and therapeutic approaches

Mary, A., Eysert, F., Checler, F., & Chami, M. (2023) · Molecular Psychiatry · doi:10.1038/s41380-022-01631-6 · Cited by 244 · see citing works

The role of T cells in age-related diseases

Carrasco, E., Heras, M. M. G. D. L., Gabandé‐Rodríguez, E., Desdín-Micó, G., Aranda, J. F., & Mittelbrunn, M. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00557-4 · Cited by 244 · see citing works

Metformin decelerates aging clock in male monkeys

Yang, Y., Lu, X., Liu, N., Ma, S., Zhang, H., Zhang, Z., Yang, K., Jiang, M., Zheng, Z., Qiao, Y., et al. (2024) · Cell · doi:10.1016/j.cell.2024.08.021 · Cited by 227 · see citing works

Targeting immune dysfunction in aging

Borgoni, S., Kudryashova, K. S., Burka, K., & de Magalhães, J. P. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101410 · Cited by 227 · see citing works

Inflammaging and the Skin

Pilkington, S. M., Bulfone‐Paus, S., Griffiths, C. E. M., & Watson, R. E. B. (2021) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.11.006 · Cited by 229 · see citing works

Autophagy in cancer development, immune evasion, and drug resistance

Niu, X., You, Q., Hou, K., Tian, Y., Wei, P., Zhu, Y., Gao, B., Ashrafizadeh, M., Aref, A. R., Kalbasi, A., et al. (2024) · Drug Resistance Updates · doi:10.1016/j.drup.2024.101170 · Cited by 217 · see citing works

Mitochondrial Oxidative Damage Underlies Regulatory T Cell Defects in Autoimmunity

Alissafi, T., Kalafati, L., Lazari, M., Filia, A., Kloukina, I., Manifava, M., Lim, J.-H., Alexaki, V. I., Ktistakis, N. T., Doskas, T. K., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.07.001 · Cited by 196 · see citing works

Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms

Chen, S., Gan, D., Lin, S., Zhong, Y., Chen, M., Zou, X., Shao, Z., & Xiao, G. (2022) · Theranostics · doi:10.7150/thno.71360 · Cited by 197 · see citing works

Aging and InflammationPreprint

Singh, A., Schurman, S. H., Bektas, A., Kaileh, M., Roy, R., Wilson, D. M., Sen, R., & Ferrucci, L. (2023) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041197 · Cited by 194 · see citing works

Cross-talk of inflammation and cellular senescence: a new insight into the occurrence and progression of osteoarthritis

Han, Z., Wang, K., Ding, S., & Zhang, M. (2024) · Bone Research · doi:10.1038/s41413-024-00375-z · Cited by 190 · see citing works

Hallmarks of the aging T‐cell system

Zhang, H., Weyand, C. M., & Goronzy, J. J. (2021) · FEBS Journal · doi:10.1111/febs.15770 · Cited by 177 · see citing works

Metformin attenuated sepsis-related liver injury by modulating gut microbiota

Liang, H., Song, H., Zhang, X., Song, G., Wang, Y., Ding, X., Duan, X., Li, L., Sun, T., & Kan, Q. (2022) · Emerging Microbes & Infections · doi:10.1080/22221751.2022.2045876 · Cited by 175 · see citing works

Senescent T cells: a potential biomarker and target for cancer therapy

Zhang, J., He, T., Xue, L., & Guo, H. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103409 · Cited by 171 · see citing works

Association Between Preadmission Metformin Use and Outcomes in Intensive Care Unit Patients With Sepsis and Type 2 Diabetes: A Cohort Study

Yang, Q., Zheng, J., Chen, W., Chen, X., Wen, D., Chen, W., Xiong, X., & Zhang, Z. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.640785 · Cited by 171 · see citing works

Targeting aging mechanisms: pharmacological perspectives

Moskalev, A., Guvatova, Z., Lopes, I. D. A., Beckett, C. W., Kennedy, B. K., De Magalhaes, J. P., & Makarov, A. A. (2022) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2022.01.007 · Cited by 164 · see citing works

Mitochondria reactive oxygen species signaling in immune responses

Weinberg, S. E., & Chandel, N. S. (2025) · Immunity · doi:10.1016/j.immuni.2025.07.012 · Cited by 166 · see citing works

Immunosenescence: Aging and Immune System Decline

Goyani, P., Christodoulou, R. C., & Vassiliou, E. K. (2024) · Vaccines · doi:10.3390/vaccines12121314 · Cited by 177 · see citing works

Metformin treatment in late middle age improves cognitive function with alleviation of microglial activation and enhancement of autophagy in the hippocampus

Kodali, M., Attaluri, S., Madhu, L. N., Shuai, B., Upadhya, R., Gonzalez, J. J., Rao, X., & Shetty, A. K. (2021) · Aging Cell · doi:10.1111/acel.13277 · Cited by 149 · see citing works

The multifaceted role of the SASP in atherosclerosis: from mechanisms to therapeutic opportunities

Sun, Y., Wang, X., Liu, T., Zhu, X., & Pan, X. (2022) · Cell & Bioscience · doi:10.1186/s13578-022-00815-5 · Cited by 151 · see citing works

Immunosenescence: signaling pathways, diseases and therapeutic targets

Fu, Y., Wang, B., Alu, A., Hong, W., Hong, L., He, X., Shi, H., Cheng, P., & Yang, X. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02371-z · Cited by 157 · see citing works

Metformin: A Novel Weapon Against Inflammation

Bai, B., & Chen, H. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.622262 · Cited by 139 · see citing works

Adaptive immune cells shape obesity-associated type 2 diabetes mellitus and less prominent comorbidities

Calvo, S. S.-C., Bharath, L. P., Pugh, G. H., SantaCruz-Calvo, L., Lenin, R. R., Lutshumba, J., Liu, R., Bachstetter, A. D., Zhu, B., & Nikolajczyk, B. S. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00575-1 · Cited by 141 · see citing works

Inflammaging as a target for healthy ageing

Dugan, B., Conway, J., & Duggal, N. A. (2023) · Age and Ageing · doi:10.1093/ageing/afac328 · Cited by 142 · see citing works

The intersection of metformin and inflammation

Bharath, L. P., & Nikolajczyk, B. S. (2021) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00604.2020 · Cited by 134 · see citing works

Targeting Senescent Cells for a Healthier Aging: Challenges and Opportunities

Song, S., Tchkonia, T., Jiang, J., Kirkland, J. L., & Sun, Y. (2020) · Advanced Science · doi:10.1002/advs.202002611 · Cited by 129 · see citing works

Hallmarks and detection techniques of cellular senescence and cellular ageing in immune cells

Zhou, D., Borsa, M., & Simon, A. K. (2021) · Aging Cell · doi:10.1111/acel.13316 · Cited by 129 · see citing works

Geroscience‐guided repurposing of FDA‐approved drugs to target aging: A proposed process and prioritization

Kulkarni, A. S., Aleksić, S., Berger, D. M., Sierra, F., Kuchel, G. A., & Barzilai, N. (2022) · Aging Cell · doi:10.1111/acel.13596 · Cited by 129 · see citing works

Insights into vaccines for elderly individuals: from the impacts of immunosenescence to delivery strategies

Hou, Y., Chen, M., Bian, Y., Hu, Y., Chuan, J., Zhong, L., Zhu, Y., & Tong, R. (2024) · npj Vaccines · doi:10.1038/s41541-024-00874-4 · Cited by 116 · see citing works

Mitochondria: In the Cross Fire of SARS-CoV-2 and Immunity

Burtscher, J., Cappellano, G., Omori, A., Koshiba, T., & Millet, G. P. (2020) · iScience · doi:10.1016/j.isci.2020.101631 · Cited by 107 · see citing works

Management of inflammation in cardiovascular diseases

Goswami, S. K., Ranjan, P., Dutta, R. K., & Verma, S. K. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105912 · Cited by 111 · see citing works

Cellular senescence, DNA damage, and neuroinflammation in the aging brain

Zhang, W., Sun, H., Wang, X., Dumont, A. S., & Liu, Q. (2024) · Trends in Neurosciences · doi:10.1016/j.tins.2024.04.003 · Cited by 113 · see citing works

Mitophagy in health and disease. Molecular mechanisms, regulatory pathways, and therapeutic implications

D'Arcy, M. (2024) · APOPTOSIS · doi:10.1007/s10495-024-01977-y · Cited by 113 · see citing works

Metabolomic analyses reveal new stage-specific features of COVID-19

Jia, H.-L., Liu, C., Li, D., Huang, Q., Liu, D., Zhang, Y., Ye, C., Zhou, D., Wang, Y., Tan, Y., et al. (2021) · European Respiratory Journal · doi:10.1183/13993003.00284-2021 · Cited by 105 · see citing works

Age-related mitochondrial dysfunction as a key factor in COVID-19 disease

Fernández‐Ayala, D. J. M., Navas, P., & López‐Lluch, G. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.111147 · Cited by 105 · see citing works

The Link between Oxidative Stress, Redox Status, Bioenergetics and Mitochondria in the Pathophysiology of ALS

Obrador, E., Palmer, R. S., López‐Blanch, R., Jihad-Jebbar, A., Vallés, S. L., & Estrela, J. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126352 · Cited by 104 · see citing works

Dysregulation of Systemic Immunity in Aging and Dementia

Lutshumba, J., Nikolajczyk, B. S., & Bachstetter, A. D. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.652111 · Cited by 103 · see citing works

Macrophage Subsets and Death Are Responsible for Atherosclerotic Plaque Formation

Li, H., Cao, Z., Wang, L., Liu, C., Lin, H., Tang, Y., & Yao, P. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.843712 · Cited by 100 · see citing works

Loss of Metabolic Plasticity Underlies Metformin Toxicity in Aged Caenorhabditis Elegans

Espada, L., Dakhovnik, A., Chaudhari, P., Martirosyan, A., Miek, L., Poliezhaieva, T., Schaub, Y., Nair, A., Döring, N., Rahnis, N., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-00307-1 · Cited by 100 · see citing works

Integrating the Hallmarks of Aging Throughout the Tree of Life: A Focus on Mitochondrial Dysfunction

van der Rijt, S., Molenaars, M., McIntyre, R. L., Janssens, G. E., & Houtkooper, R. H. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.594416 · Cited by 97 · see citing works

Metformin for Cardiovascular Protection, Inflammatory Bowel Disease, Osteoporosis, Periodontitis, Polycystic Ovarian Syndrome, Neurodegeneration, Cancer, Inflammation and Senescence: What Is Next?

Ala, M., & Ala, M. (2021) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.1c00167 · Cited by 96 · see citing works

Metformin suppresses vascular smooth muscle cell senescence by promoting autophagic flux

Tai, S., Sun, J., Zhou, Y., Zhu, Z., He, Y., Chen, M., Yang, H., Xiao, Y., Tu, T., Tang, L., et al. (2021) · Journal of Advanced Research · doi:10.1016/j.jare.2021.12.009 · Cited by 98 · see citing works

Graphene oxide nanoarchitectures in cancer biology: Nano-modulators of autophagy and apoptosis

Taheriazam, A., Abad, G. G. Y., Hajimazdarany, S., Imani, M. H., Ziaolhagh, S., Zandieh, M. A., Bayanzadeh, S. D., Mirzaei, S., Hamblin, M. R., Entezari, M., et al. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.01.028 · Cited by 93 · see citing works

Thymus involution sets the clock of the aging T-cell landscape: Implications for declined immunity and tissue repair

Elyahu, Y., & Monsonego, A. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101231 · Cited by 91 · see citing works

Energy metabolism as therapeutic target for aged wound repair by engineered extracellular vesicle

Zhuang, Y., Jiang, S., Deng, X., Lao, A., Hua, X., Xie, Y., Jiang, L., Wang, X., & Lin, K. (2024) · Science Advances · doi:10.1126/sciadv.adl0372 · Cited by 91 · see citing works

Targeting immunosenescence and inflammaging: advancing longevity research

Nguyen, T. Q. T., & Cho, K. A. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01527-9 · Cited by 94 · see citing works

Targeting lymphoid-derived IL-17 signaling to delay skin aging

Solá, P., Mereu, E., Bonjoch, J., Casado-Peláez, M., Prats, N., Aguilera, M., Reina, Ó., Blanco, E., Esteller, M., Croce, L. D., et al. (2023) · Nature Aging · doi:10.1038/s43587-023-00431-z · Cited by 86 · see citing works

The beneficial role of autophagy in multiple sclerosis: Yes or No?

Al-Kuraishy, H. M., Jabir, M. S., Al-Gareeb, A. I., Saad, ‏. M., Batiha, G. E., & Klionsky, D. J. (2023) · Autophagy · doi:10.1080/15548627.2023.2259281 · Cited by 86 · see citing works

Metformin in therapeutic applications in human diseases: its mechanism of action and clinical study

Du, Y., Zhu, Y., Zhou, Y., Ding, J., & Liu, J. (2022) · Molecular Biomedicine · doi:10.1186/s43556-022-00108-w · Cited by 82 · see citing works

Metformin enhances anti-mycobacterial responses by educating CD8+ T-cell immunometabolic circuits

Böhme, J., Martínez, N., Li, S., Lee, A., Marzuki, M., Tizazu, A. M., Ackart, D. F., Haugen, J. D., Todd, A., Lachmandas, E., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19095-z · Cited by 81 · see citing works

Metformin Attenuates Silica-Induced Pulmonary Fibrosis by Activating Autophagy via the AMPK-mTOR Signaling Pathway

Li, S., Li, C. R., Pang, X., Zhang, J., Yu, G., Yeo, A. J., Lavin, M. F., Shao, H., Jia, Q., & Peng, C. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.719589 · Cited by 81 · see citing works

Exploring the Pharmacological Potential of Metformin for Neurodegenerative Diseases

Du, M., Gao, Q.-Y., Liu, C., Bai, L.-Y., Li, T. X., & Wei, F. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.838173 · Cited by 79 · see citing works

Senescence-Associated Secretory Phenotype of Cardiovascular System Cells and Inflammaging: Perspectives of Peptide Regulation

Khavinson, V., Linkova, N. S., Dyatlova, A., Кантемирова, Р. К., & Kozlov, K. L. (2022) · Cells · doi:10.3390/cells12010106 · Cited by 78 · see citing works

A guide to membrane atg8ylation and autophagy with reflections on immunity

Deretic, V. P., & Lazarou, M. (2022) · The Journal of Cell Biology · doi:10.1083/jcb.202203083 · Cited by 78 · see citing works

Inflammatory macrophages reprogram to immunosuppression by reducing mitochondrial translation

Cortés, M., Brischetto, A., Martínez-Campanario, M. C., Ninfali, C., Domínguez, V., Fernández, S., Celis, R., Esteve‐Codina, A., Lozano, J. J., Sidorova, J., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42277-4 · Cited by 75 · see citing works

Long-term treatment of Nicotinamide mononucleotide improved age-related diminished ovary reserve through enhancing the mitophagy level of granulosa cells in mice

Huang, P., Zhou, Y., Tang, W., Ren, C., Jiang, A., Wang, X., Qian, X., Zhou, Z., & Gong, A. (2021) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2021.108911 · Cited by 74 · see citing works

Obesity accelerates cardiovascular ageing

Ruperez, C., Madeo, F., de Cabo, R., Kroemer, G., & Abdellatif, M. (2025) · European Heart Journal · doi:10.1093/eurheartj/ehaf216 · Cited by 73 · see citing works

Smart battery-free and wireless bioelectronic platform based on a nature-skin-derived organohydrogel for chronic wound diagnosis, assessment, and accelerated healing

Bai, Z., Wang, X., Huang, M.-C., Feng, Y., Sun, S., Zheng, M., Zou, X., Xie, L., Wang, X., Hao, D., et al. (2023) · Nano Energy · doi:10.1016/j.nanoen.2023.108989 · Cited by 73 · see citing works

Metformin normalizes mitochondrial function to delay astrocyte senescence in a mouse model of Parkinson’s disease through Mfn2-cGAS signaling

Wang, M., Tian, T., Zhou, H., Jiang, S., Jiao, Y., Zhu, Z., Xia, J., Ma, J., & Du, R. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03072-0 · Cited by 75 · see citing works

Mitochondrial dysfunction in the fetoplacental unit in gestational diabetes mellitus

Sobrevía, L., Valero, P., Grismaldo, A., Villalobos-Labra, R., Pardo, F., Subiabre, M., Armstrong, G. A., Toledo, F., Vega, S., Cornejo, M., et al. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165948 · Cited by 74 · see citing works

Metformin selectively dampens the acute inflammatory response through an AMPK-dependent mechanism

Postler, T. S., Peng, V., Bhatt, D. M., & Ghosh, S. (2021) · Scientific Reports · doi:10.1038/s41598-021-97441-x · Cited by 72 · see citing works

Cognitive Impairment in Frail Hypertensive Elderly Patients: Role of Hyperglycemia

Mone, P., Gambardella, J., Pansini, A., Donato, A. D., Martinelli, G., Boccalone, E., Matarese, A., Frullone, S., & Santulli, G. (2021) · Cells · doi:10.3390/cells10082115 · Cited by 70 · see citing works

Autophagy and autophagy signaling in Epilepsy: possible role of autophagy activator

Ali, N. H., Al-Kuraishy, H. M., Al-Gareeb, A. I., Alnaaim, S. A., Alexiou, A. T., Papadakis, M., Saad, ‏. M., & Batiha, G. E. (2023) · Molecular Medicine · doi:10.1186/s10020-023-00742-2 · Cited by 73 · see citing works

Innate and Adaptive Immunity in Aging and Longevity: The Foundation of Resilience

Moskalev, A., Stambler, I., & Caruso, C. (2020) · Aging and Disease · doi:10.14336/ad.2020.0603 · Cited by 71 · see citing works

Role of Senescence and Aging in SARS-CoV-2 Infection and COVID-19 Disease

Lynch, S. M., Guo, G., Gibson, D. S., Bjourson, A. J., & Singh, T. (2021) · Cells · doi:10.3390/cells10123367 · Cited by 69 · see citing works

Macrophages and T cells in metabolic disorder-associated cancers

Taranto, D., Kloosterman, D., & Akkari, L. (2024) · Nature Reviews. Cancer · doi:10.1038/s41568-024-00743-1 · Cited by 67 · see citing works

The effects of age and systemic metabolism on anti-tumor T cell responses

Drijvers, J. M., Sharpe, A. H., & Haigis, M. C. (2020) · eLife · doi:10.7554/elife.62420 · Cited by 69 · see citing works

Crosstalk Between ROS and Autophagy in Tumorigenesis: Understanding the Multifaceted Paradox

Hasan, A., Rizvi, S. F., Parveen, S., Pathak, N., Nazir, A., & Mir, S. S. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.852424 · Cited by 71 · see citing works

Effect of metformin on stem cells: Molecular mechanism and clinical prospect

Jiang, L., & Liu, L. (2020) · World Journal of Stem Cells · doi:10.4252/wjsc.v12.i12.1455 · Cited by 68 · see citing works

The pyruvate dehydrogenase complex: Life’s essential, vulnerable and druggable energy homeostat

Stacpoole, P. W., & McCall, C. E. (2023) · Mitochondrion · doi:10.1016/j.mito.2023.02.007 · Cited by 68 · see citing works

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Jin, S., Li, K., Zong, X., Eun, S., Morimoto, N., & Guo, S. (2023) · Aging and Disease · doi:10.14336/ad.2023.0321 · Cited by 67 · see citing works

Metformin's Mechanisms in Attenuating Hallmarks of Aging and Age-Related Disease

Cheng, F., Liu, Y.-L., Du, J., & Lin, J. (2022) · Aging and Disease · doi:10.14336/ad.2021.1213 · Cited by 69 · see citing works

Impact of aging on treatment considerations for multiple sclerosis patients

Macaron, G., Larochelle, C., Arbour, N., Galmard, M., Girard, M., Prat, A., & Duquette, P. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1197212 · Cited by 67 · see citing works

Neuroprotective Effects of Metformin Through the Modulation of Neuroinflammation and Oxidative Stress

Reed, S., Taka, E., Darling‐Reed, S., & Soliman, K. F. A. (2025) · Cells · doi:10.3390/cells14141064 · Cited by 71 · see citing works

Transcranial Magneto-Acoustic Stimulation Attenuates Synaptic Plasticity Impairment through the Activation of Piezo1 in Alzheimer’s Disease Mouse Model

Chu, F., Tan, R., Wang, X., Zhou, X., Ma, R., Ma, X., Li, Y., Liu, R., Zhang, C., Liu, X., et al. (2023) · Research · doi:10.34133/research.0130 · Cited by 65 · see citing works

Mitochondrial Quality Control via Mitochondrial Unfolded Protein Response (mtUPR) in Ageing and Neurodegenerative Diseases

Cilleros-Holgado, P., Gómez-Fernández, D., Piñero-Pérez, R., Romero-Domínguez, J. M., Reche-López, D., López-Cabrera, A., Álvarez-Córdoba, M., Munuera-Cabeza, M., Talaverón-Rey, M., Suárez-Carrillo, A., et al. (2023) · Biomolecules · doi:10.3390/biom13121789 · Cited by 67 · see citing works

Cross talk between autophagy and oncogenic signaling pathways and implications for cancer therapy

Zada, S., Hwang, J. S., Ahmed, M., Lai, T. H., Pham, T. M., Elashkar, O., & Kim, D. R. (2021) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2021.188565 · Cited by 64 · see citing works

The anti-aging mechanism of ginsenosides with medicine and food homology

Tian, T., Ko, C.-N., Luo, W., Li, D., & Yang, C. (2023) · Food & Function · doi:10.1039/d3fo02580b · Cited by 62 · see citing works

The effect of <scp>GLP</scp> ‐1 receptor agonists on circulating inflammatory markers in type 2 diabetes patients: A systematic review and meta‐analysis

Ren, Y., Chen, Y., Zheng, W., Kong, W., Liao, Y., Zhang, J., Wang, M., & Zeng, T. (2025) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.16366 · Cited by 59 · see citing works

Four-octyl itaconate improves osteoarthritis by enhancing autophagy in chondrocytes via PI3K/AKT/mTOR signalling pathway inhibition

Pan, X., Shan, H., Bai, J., Gao, T., Chen, B., Shen, Z., Zhou, H., Lu, H., Sheng, L., & Zhou, X. (2022) · Communications Biology · doi:10.1038/s42003-022-03592-6 · Cited by 59 · see citing works

cGAS‐STING mediates cytoplasmic mitochondrial‐DNA‐induced inflammatory signal transduction during accelerated senescence of pancreatic β‐cells induced by metabolic stress

Hu, H., Zhao, R., He, Q., Cui, C., Song, J., Guo, X., Zang, N., Yang, M., Zou, Y., Yang, J., et al. (2022) · The FASEB Journal · doi:10.1096/fj.202101988r · Cited by 59 · see citing works

PET- and ICT-Based Ratiometric Probe: An Unusual Phenomenon of Morpholine-Conjugated Fluorophore for Mitochondrial pH Mapping during Mitophagy

Munan, S., Ali, M., Yadav, R., Mapa, K., & Samanta, A. (2022) · Analytical Chemistry · doi:10.1021/acs.analchem.2c02177 · Cited by 57 · see citing works

The Anti-Aging Mechanism of Metformin: From Molecular Insights to Clinical Applications

Zhang, T., Li-jun, Z., Makarczyk, M. J., Feng, P., & Zhang, J. (2025) · Molecules · doi:10.3390/molecules30040816 · Cited by 62 · see citing works

Fully armed photodynamic therapy with spear and shear for topical deep hypertrophic scar treatment

Huang, Y., Peng, T., Hu, W., Gao, X., Chen, Y., Zhang, Q., Wu, C., & Pan, X. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.01.043 · Cited by 58 · see citing works

Mitochondria during T cell aging

Escrig-Larena, J. I., Delgado-Pulido, S., & Mittelbrunn, M. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101808 · Cited by 58 · see citing works

T helper 17 cells: A new actor on the stage of type 2 diabetes and aging?

Chang, Y., Hee, S., & Chuang, L. (2021) · Journal of Diabetes Investigation · doi:10.1111/jdi.13541 · Cited by 13 · see citing works

A unique inflammaging profile generated by T cells from people with obesity is metformin resistant

Calvo, S. S.-C., Saraswat, S., Kalantar, G. H., Zukowski, E., Marszalkowski, H., Javidan, A., Gholamrezaeinejad, F., Bharath, L. P., Kern, P. A., Zhang, X. D., et al. (2024) · GeroScience · doi:10.1007/s11357-024-01441-4 · Cited by 2 · see citing works

CD4+ T Cells at the Center of Inflammaging

Kroemer, G., & Zitvogel, L. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.04.016 · Cited by 29 · see citing works

The biological mechanisms of metformin effects on aging-associated inflammation in obesity

Calvo, S. S.-C., Bharath, L. P., & Nikolajczyk, B. S. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.208.supp.165.24

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Shu-ping, Y., Su, Q., Zhang, Y., Sun, Y., & Chai, Y. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108744 · Cited by 14 · see citing works