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Cited by 437

The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.

Immunohistochemistry as an Important Tool in Biomarkers Detection and Clinical Practice

Open access
De Matos, Leandro Luongo, Trufelli, Damila Cristina, De Matos, Maria Graciela Luongo, Da Silva Pinhal, Maria Aparecida·2010·Biomarker Insights
DOI 10.4137/bmi.s2185
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Abstract

The immunohistochemistry technique is used in the search for cell or tissue antigens that range from amino acids and proteins to infectious agents and specific cellular populations. The technique comprises two phases: (1) slides preparation and stages involved for the reaction; (2) interpretation and quantification of the obtained expression. Immunohistochemistry is an important tool for scientific research and also a complementary technique for the elucidation of differential diagnoses which are not determinable by conventional analysis with hematoxylin and eosin. In the last couple of decades there has been an exponential increase in publications on immunohistochemistry and immunocytochemistry techniques. This review covers the immunohistochemistry technique; its history, applications, importance, limitations, difficulties, problems and some aspects related to results interpretation and quantification. Future developments on the immunohistochemistry technique and its expression quantification should not be disseminated in two languages–-that of the pathologist and another of clinician or surgeon. The scientific, diagnostic and prognostic applications of this methodology must be explored in a bid to benefit of patient. In order to achieve this goal a collaboration and pooling of knowledge from both of these valuable medical areas is vital

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Metadata

Authors
De Matos, L. L., Trufelli, D. C., De Matos, M. G. L., & Da Silva Pinhal, M. A.
Venue
Biomarker Insights
Publisher
SAGE Publications
Published
2010-01
Volume
5
Pages
BMI.S2185
ISSN
1177-2719 (ISSN-L)
DOI
10.4137/bmi.s2185
OpenAlex
W2044758669
Cited by
437
References
63
FWCI
3.42
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Immunohistochemistry as an Important Tool in Biomarkers Detection and Clinical Practice. https://app.cochat.ai/papers/10.4137/bmi.s2185
The paper
De Matos, L. L., Trufelli, D. C., De Matos, M. G. L., & Da Silva Pinhal, M. A. (2010). Immunohistochemistry as an Important Tool in Biomarkers Detection and Clinical Practice. Biomarker Insights. https://doi.org/10.4137/bmi.s2185

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