The DOI matches its Crossref record; 368 of the 371 references it cites were found in a registry or an index.
Reactive Oxygen Species: Physiological and Physiopathological Effects on Synaptic Plasticity: Supplementary Issue: Brain Plasticity and Repair
Open accessAbstract
In the mammalian central nervous system, reactive oxygen species (ROS) generation is counterbalanced by antioxidant defenses. When large amounts of ROS accumulate, antioxidant mechanisms become overwhelmed and oxidative cellular stress may occur. Therefore, ROS are typically characterized as toxic molecules, oxidizing membrane lipids, changing the conformation of proteins, damaging nucleic acids, and causing deficits in synaptic plasticity. High ROS concentrations are associated with a decline in cognitive functions, as observed in some neurodegenerative disorders and age-dependent decay of neuroplasticity. Nevertheless, controlled ROS production provides the optimal redox state for the activation of transductional pathways involved in synaptic changes. Since ROS may regulate neuronal activity and elicit negative effects at the same time, the distinction between beneficial and deleterious consequences is unclear. In this regard, this review assesses current research and describes the main sources of ROS in neurons, specifying their involvement in synaptic plasticity and distinguishing between physiological and pathological processes implicated.
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“Nevertheless, adequate ROS concentration regulates neuron activation to allow synaptic connection95.”
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Metadata
- Authors
- Beckhauser, T. F., Francis-Oliveira, J., & De Pasquale, R.
- Affiliations
- Universidade de São Paulo (BR)
- Physiology and Biophysics Department, Biomedical Sciences Institute, Sao Paulo University (USP), Butanta, Sao Paulo, Brazil
- Venue
- Journal of Experimental Neuroscience
- Publisher
- SAGE Publications
- Published
- 2016-01
- Volume
- 10s1
- Issue
- Suppl 1
- Pages
- 23-48
- ISSN
- 1179-0695 (ISSN-L)
- PMC
- PMC5012454
- OpenAlex
- W2508720811
- Cited by
- 301
- References
- 371
- Citations by year
- 2026: 20 · 2025: 33 · 2024: 27 · 2023: 28 · 2022: 43 · 2021: 45 · 2020: 40 · 2019: 35 · 2018: 21 · 2017: 9
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of Experimental Neuroscience (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- reactive oxygen species, synaptic plasticity, oxidative stress, antioxidant defense, redox signaling, neurodegenerative diseases, cognitive decline, lipid peroxidation, protein oxidation, neuroplasticity
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