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Cited by 135Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNeural dynamics and brain function

Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path

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Bliss, T. V. P., Lømo, T.·1973·The Journal of Physiology
DOI 10.1113/jphysiol.1973.sp010273PMC PMC1350458
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Abstract

1. The after‐effects of repetitive stimulation of the perforant path fibres to the dentate area of the hippocampal formation have been examined with extracellular micro‐electrodes in rabbits anaesthetized with urethane. 2. In fifteen out of eighteen rabbits the population response recorded from granule cells in the dentate area to single perforant path volleys was potentiated for periods ranging from 30 min to 10 hr after one or more conditioning trains at 10–20/sec for 10–15 sec, or 100/sec for 3–4 sec. 3. The population response was analysed in terms of three parameters: the amplitude of the population excitatory post‐synaptic potential (e.p.s.p.), signalling the depolarization of the granule cells, and the amplitude and latency of the population spike, signalling the discharge of the granule cells. 4. All three parameters were potentiated in 29% of the experiments; in other experiments in which long term changes occurred, potentiation was confined to one or two of the three parameters. A reduction in the latency of the population spike was the commonest sign of potentiation, occurring in 57% of all experiments. The amplitude of the population e.p.s.p. was increased in 43%, and of the population spike in 40%, of all experiments. 5. During conditioning at 10–20/sec there was massive potentiation of the population spike (‘frequency potentiation’). The spike was suppressed during stimulation at 100/sec. Both frequencies produced long‐term potentiation. 6. The results suggest that two independent mechanisms are responsible for long‐lasting potentiation: ( a ) an increase in the efficiency of synaptic transmission at the perforant path synapses; ( b ) an increase in the excitability of the granule cell population.

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  • LTP induction requires, in at least one of its forms, the activation of NMDARs.

    “Long-term potentiation (LTP) is a widely used paradigm for increasing synaptic efficacy, and its induction requires, in at least one of its forms, the activation of NMDARs (Bliss and Lømo, 1973; Bliss and Collingridge, 1993).”

    From The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. (1996) · cites this paper as Bliss and Lømo, 1973

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Authors
Bliss, T. V. P., & Lømo, T.
ORCID
Lømo, T.
Venue
The Journal of Physiology
Publisher
Wiley
Published
1973-07
Volume
232
Issue
2
Pages
331-356
ISSN
  • 0022-3751 (ISSN-L)
  • 1469-7793
DOI
10.1113/jphysiol.1973.sp010273
PMC
PMC1350458
OpenAlex
W7214220836
Cited by
135
References
0
Citations by year
2026: 9 · 2025: 2 · 2024: 5 · 2023: 6 · 2022: 8 · 2021: 17 · 2020: 8 · 2018: 2 · 2017: 22 · 2016: 4 · 2015: 9 · 2014: 9 · 2013: 2 · 2012: 3
FWCI
0.17
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • The Journal of Physiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
long-term potentiation, perforant path, dentate gyrus, granule cells, hippocampus, synaptic transmission, population spike, excitatory postsynaptic potentials, frequency potentiation, synaptic plasticity, excitability
MeSH terms
Action Potentials, Anesthesia, Intravenous, Animals, Electric Stimulation, Electrophysiology, Evoked Potentials, Female, Hippocampus, Male, Microelectrodes, Neurons, Rabbits, Synapses, Time Factors

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