The Need for Psychosocial Interventions to Facilitate the Transition to Extended-Release Naltrexone (XR-NTX) Treatment for Opioid Dependence: A Concise Review of the Literature
Open accessAbstract
Given the increase of opioid dependence and opioid-related morbidity and mortality, improving treatment options for individuals with opioid dependence warrants increased attention. This article provides a concise review of work in this area. Remission from opioid dependence can be very difficult to sustain, particularly in the absence of opioid replacement or opioid antagonist therapy. For those who wish to transition from opioid use or opioid replacement therapy to opioid antagonist therapy, a significant challenge can be the period of withdrawal symptoms that must be endured prior to the initiation of opioid antagonist therapy. Studies that have incorporated psychosocial interventions into detoxification protocols have found that they can result in improved treatment outcomes. Interventions based on Acceptance and Commitment Therapy have shown promise in the treatment of clinical disorders that present with symptoms similar to those of opioid withdrawal and have been found to positively impact outcomes among those tapering from methadone. However, the use of an Acceptance and Commitment Therapy-based intervention has yet to be studied among opioid-dependent patients transitioning to XR-NTX, and its value to those transitioning to XR-NTX is currently unknown.
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ACT is well suited to cancer populations as it offers a model of healthy adaptation to difficult circumstances and has shown promise in the treatment of opioid misuse.
“ACT is well suited to cancer populations as it offers a model of healthy adaptation to difficult circumstances and has shown promise in the treatment of opioid misuse [45].”
From Pre- and post-operative psychological interventions to prevent pain and fatigue after breast cancer surgery (PREVENT): Protocol for a randomized controlled trial (2022) · cites this paper as [45]
The section “Acceptance and Commitment Therapy may Assist with Transition to XR-NTX” (page not supplied) describes ACT as fostering adaptive responses to distress and reports lower opioid use in an ACT study. It does not address cancer populations, so the claim that ACT is well suited to them is an extrapolation beyond this source. (LLM, conf=0.86)
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- Authors
- Ramsey, S. E., Rounsaville, D., Hoskinson, R., Park, T. W., Ames, E. G., Neirinckx, V. D., & Friedmann, P.
- Affiliations
- Brown University (US)
- VA Boston Healthcare System, Brockton, MA, USA.
- Baystate Health (US)
- Rhode Island Hospital (US)
- Corresponding author
- Ramsey, Susan E.
- Venue
- Substance Abuse: Research and Treatment
- Publisher
- SAGE Publications
- Published
- 2016-01
- Volume
- 10
- Pages
- 65-8
- ISSN
- 1178-2218 (ISSN-L)
- PMC
- PMC4975246
- OpenAlex
- W2496498085
- Cited by
- 8
- References
- 43
- Citations by year
- 2025: 1 · 2022: 2 · 2018: 4 · 2017: 1
- FWCI
- 0.25
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Substance Abuse Research and Treatment (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Institute on Drug Abuse (R34DA037797)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
- Keywords
- extended-release naltrexone, opioid use disorder, psychosocial interventions, opioid antagonist therapy, opioid withdrawal, detoxification, acceptance and commitment therapy, treatment transition, opioid substitution therapy
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