The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Photodynamic Effects of Radachlorin® on Cervical Cancer Cells
Open accessAbstract
PURPOSE: Photodynamic therapy (PDT) is a novel treatment modality, which produces local tissue necrosis with laser light following the prior administration of a photosensitizing agent. Radachlorin has recently been shown to be a promising PDT sensitizer. In order to elucidate the antitumor effects of PDT using Radachlorin on cervical cancer, growth inhibition studies on a HPV-associated tumor cell line, TC-1 cells in vitro and animals with an established TC-1 tumor in vivo were determined. MATERIALS AND METHODS: TC-1 tumor cells were exposed to various concentrations of Radachlorin and PDT, with irradiation of 12.5 or 25 J/cm(2) at an irradiance of 20 mW/cm(2) using a Won-PDT D662 laser at 662 nm in vitro. C57BL/6 mice with TC-1 tumor were injected with Radachlorin via different routes and treated with PDT in vivo. A growth suppression study was then used to evaluate the effects at various time points after PDT. RESULTS: The results showed that irradiation of TC-1 tumor cells in the presence of Radachlorin induced significant cell growth inhibition. Animals with established TC-1 tumors exhibited significantly smaller tumor sizes over time when treated with Radachlorin and irradiation. CONCLUSION: PDT after the application of Radachlorin appears to be effective against TC-1 tumors both in vitro and in vivo.
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“They proved that the degree of cytotoxicity correlated with the concentration of the photosensitizer, in this case photophrin.”
From Photodynamic Therapy for Thyroid Cancer (2025) · cites this paper as [43]
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“In addition, after 24 hours, this group also showed the most marked indicators of cell death, including necrosis, apoptosis, and increased expression of caspase 3, caspase 9, and PARP.”
From Photodynamic Therapy for Thyroid Cancer (2025) · cites this paper as [43]
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“Cellular cytotoxicity was most pronounced in the group of cells exposed to photophrin-PDT at a photophrin concentration of 3.2 μ g/ml, compared to photophrin-PDT at a photophrin concentration of 1.6 μ g/ml and using only photophrin without a laser.”
From Photodynamic Therapy for Thyroid Cancer (2025) · cites this paper as [43]
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“Studies on the effect of PDT with hypericin, porphyrin, photophrin, radachlorin or 5-aminolevulinic acid as PS on thyroid cancer have shown promising effects”
From Photodynamic Therapy for Thyroid Cancer (2025) · cites this paper as [43]
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“indicating that cell death was most likely mediated by mitochondria.”
From Photodynamic Therapy for Thyroid Cancer (2025) · cites this paper as [43]
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“they found that photophrin accumulated mainly in the mitochondria of anaplastic cancer cells”
From Photodynamic Therapy for Thyroid Cancer (2025) · cites this paper as [43]
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“Caspase 8 expression was similar to the control group.”
From Photodynamic Therapy for Thyroid Cancer (2025) · cites this paper as [43]
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Citations
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Cited by
Sorted by citations
Photodynamic Therapy for Thyroid Cancer
Inglot, J., Strzelczyk, J. K., Bartusik-Aebisher, D., & Aebisher, D. (2025) · BioMed · doi:10.3390/biomed5010008 · Cited by 2
Metadata
- Authors
- Bae, S.-M., Kim, Y.-W., Lee, J.-M., Namkoong, S.-E., Han, S.-J., Kim, J.-K., Lee, C.-H., Chun, H.-J., Jin, H.-S., & Ahn, W.-S.
- Affiliations
- Catholic University of Korea (KR)
- Department of Chemistry, Kangwon University, Gangwondo, Korea.
- Venue
- Cancer Research and Treatment
- Publisher
- Korean Cancer Association
- Published
- 2004
- Volume
- 36
- Issue
- 6
- Pages
- 389
- ISSN
- 1598-2998 (ISSN-L)
- PMC
- PMC2843882
- OpenAlex
- W1975603157
- Cited by
- 26
- References
- 1
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2020: 1 · 2016: 2 · 2015: 3 · 2014: 6 · 2013: 4
- FWCI
- 0.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cancer Research and Treatment (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- ResearchSpace (University of Auckland) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Health Sciences › Medicine › Dermatology › Nonmelanoma Skin Cancer Studies
- Keywords
- photodynamic therapy, Radachlorin, cervical cancer, photosensitizers, TC-1 cells, tumor growth inhibition, anticancer activity
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- Bae, S.-M., Kim, Y.-W., Lee, J.-M., Namkoong, S.-E., Han, S.-J., Kim, J.-K., Lee, C.-H., Chun, H.-J., Jin, H.-S., & Ahn, W.-S. (2004). Photodynamic Effects of Radachlorin® on Cervical Cancer Cells. Cancer Research and Treatment. https://doi.org/10.4143/crt.2004.36.6.389
