Cited by 178Cancer Cells and MetastasisTGF-β signaling in diseasesMechanisms of cancer metastasis

Epithelial mesenchymal transition in drug resistance and metastasis of lung cancer

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Nurwidya, Fariz, Takahashi, Fumiyuki, Murakami, Akiko, Takahashi, Kazuhisa·2012·Cancer Research and Treatment

Abstract

Among all types of cancer, incidence of lung cancer remains the highest with regard to cancer-related mortality. Problems contributing to recurrence of the disease include metastasis and drug resistance. Mounting evidence has demonstrated involvement of epithelial mesenchymal transition (EMT) in cancer progression. EMT is a critical mechanism ensuring tissue remodeling during morphogenesis of multicellular organisms. Therefore, understanding of the biology of this process for identification of potential EMT-targeted therapeutic strategies for the benefit cancer patients is necessary. This review describes recent evidence of EMT involvement in drug resistance and metastasis of cancers, with an emphasis on lung cancer.

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Authors
Nurwidya, F., Takahashi, F., Murakami, A., & Takahashi, K.
Affiliations
Juntendo University (JP)
Corresponding author
Nurwidya, Fariz
Venue
Cancer Research and Treatment
Published
2012-09-30
Volume
44
Issue
3
Pages
151-156
ISSN
  • 1598-2998 (ISSN-L)
  • 2005-9256
OpenAlex
W2046847797
Cited by
177
References
62
Citations by year
2026: 5 · 2025: 8 · 2024: 4 · 2023: 5 · 2022: 9 · 2021: 10 · 2020: 13 · 2019: 14 · 2018: 13 · 2017: 16 · 2016: 21 · 2015: 20 · 2014: 17 · 2013: 21 · 2012: 1
FWCI
9.34
Type
journal article
Language
en
Open access
Locations
  • Cancer Research and Treatment (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
Keywords
epithelial-mesenchymal transition, lung cancer, drug resistance, metastasis, tumor progression, tissue remodeling

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