Epithelial mesenchymal transition in drug resistance and metastasis of lung cancer
Open accessAbstract
Among all types of cancer, incidence of lung cancer remains the highest with regard to cancer-related mortality. Problems contributing to recurrence of the disease include metastasis and drug resistance. Mounting evidence has demonstrated involvement of epithelial mesenchymal transition (EMT) in cancer progression. EMT is a critical mechanism ensuring tissue remodeling during morphogenesis of multicellular organisms. Therefore, understanding of the biology of this process for identification of potential EMT-targeted therapeutic strategies for the benefit cancer patients is necessary. This review describes recent evidence of EMT involvement in drug resistance and metastasis of cancers, with an emphasis on lung cancer.
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EMT imparts enhanced migratory and invasive capacity, survival advantage under stress, and increased resistance to apoptotic stimuli.
“This transition imparts enhanced migratory and invasive capacity, survival advantage under stress, and increased resistance to apoptotic stimuli [39,131,132,133].”
From Modeling Tumor Microenvironment Complexity In Vitro: Spheroids as Physiologically Relevant Tumor Models and Strategies for Their Analysis (2025) · cites this paper as [132]
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- Authors
- Nurwidya, F., Takahashi, F., Murakami, A., & Takahashi, K.
- Affiliations
- Juntendo University (JP)
- Corresponding author
- Nurwidya, Fariz
- Venue
- Cancer Research and Treatment
- Publisher
- Korean Cancer Association
- Published
- 2012-09-30
- Volume
- 44
- Issue
- 3
- Pages
- 151-156
- ISSN
- 1598-2998 (ISSN-L)
- 2005-9256
- PMC
- PMC3467417
- OpenAlex
- W2046847797
- Cited by
- 177
- References
- 62
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 4 · 2023: 5 · 2022: 9 · 2021: 10 · 2020: 13 · 2019: 14 · 2018: 13 · 2017: 16 · 2016: 21 · 2015: 20 · 2014: 17 · 2013: 21 · 2012: 1
- FWCI
- 9.34
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Cancer Research and Treatment (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
- Keywords
- epithelial-mesenchymal transition, lung cancer, drug resistance, metastasis, tumor progression, tissue remodeling
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