The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Gallium-Containing Anticancer Compounds
Open accessAbstract
There is an ever pressing need to develop new drugs for the treatment of cancer. Gallium nitrate, a group IIIa metal salt, inhibits the proliferation of tumor cells in vitro and in vivo and has shown activity against non-Hodgkin's lymphoma and bladder cancer in clinical trials. Gallium can function as an iron mimetic and perturb iron-dependent proliferation and other iron-related processes in tumor cells. Gallium nitrate lacks crossresistance with conventional chemotherapeutic drugs and is not myelosuppressive; it can be used when other drugs have failed or when the blood count is low. Given the therapeutic potential of gallium, newer generations of gallium compounds are now in various phases of preclinical and clinical development. These compounds hold the promise of greater anti-tumor activity against a broader spectrum of cancers. The development of gallium compounds for cancer treatment and their mechanisms of action will be discussed.
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Cites
Two to tango: Regulation of Mammalian iron metabolism
Hentze, M. W., Muckenthaler, M. U., Galy, B., & Camaschella, C. (2010) · Cell · doi:10.1016/j.cell.2010.06.028 · Cited by 2,120
Habashy, H. O., Powe, D. G., Staka, C. M., Rakha, E. A., Ball, G., Green, A. R., Aleskandarany, M., Paish, E. C., Douglas Macmillan, R., Nicholson, R. I., et al. (2010) · Breast Cancer Research and Treatment · doi:10.1007/s10549-009-0345-x · Cited by 236
Tissue ferritin concentration and prognosis in carcinoma of the breast
Weinstein, R. E., Bond, B. H., Silberberg, B. K., Vaughn, C. B., Subbaiah, P., & Pieper, D. R. (1989) · Breast Cancer Research and Treatment · doi:10.1007/bf01806307 · Cited by 50
Cited by
Next-Generation Metal Anticancer Complexes: Multitargeting via Redox Modulation
Romero-Canelón, I., & Sadler, P. J. (2013) · Inorganic Chemistry · doi:10.1021/ic400835n · Cited by 396
Gallium-mediated siderophore quenching as an evolutionarily robust antibacterial treatment
Ross-Gillespie, A., Weigert, M., Brown, S. P., & Kümmerli, R. (2014) · Evolution, Medicine, and Public Health · doi:10.1093/emph/eou003 · Cited by 104
Metadata
- Authors
- Chitambar, C. R.
- Venue
- Future Medicinal Chemistry
- Publisher
- Informa UK Limited
- Published
- 2012-06
- Volume
- 4
- Issue
- 10
- Pages
- 1257-1272
- ISSN
- 1756-8919 (ISSN-L)
- 1756-8927
- OpenAlex
- W2023185574
- Cited by
- 198
- References
- 3
- FWCI
- 2.98
- Type
- journal article
- Language
- en
- Open access
- green
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