The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Drug Delivery to the lungs: Challenges and Opportunities
Abstract
Pulmonary drug delivery is relatively complex because the respiratory tract has evolved defense mechanisms to keep inhaled drug particles out of the lungs and to remove or inactivate them once deposited. In addition to these mechanical, chemical and immunological barriers, pulmonary drug delivery is adversely affected by the behavioral barriers of poor adherence and poor inhaler technique. Strategies to mitigate the effects of these barriers include use of inhaler devices and formulations that deliver drug to the lungs efficiently, appropriate inhaler technique and improved education of patients. Owing to the advantages offered by the pulmonary route, the challenges that the route poses are worth addressing, and if successfully addressed, the pulmonary route offers huge opportunities, often fulfilling unmet clinical needs.
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Cites
Inhaled Iloprost for Severe Pulmonary Hypertension
Olschewski, H., Simonneau, G., Galiè, N., Higenbottam, T., Naeije, R., Rubin, L. J., Nikkho, S., Speich, R., Hoeper, M. M., Behr, J., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa020204 · Cited by 1,783
Labiris, N. R., & Dolovich, M. B. (2003) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.2003.01892.x · Cited by 1,245
What the pulmonary specialist should know about the new inhalation therapies
Laube, B. L., Janssens, H. M., de Jongh, F. H. C., Devadason, S. G., Dhand, R., Diot, P., Everard, M. L., Horvath, I., Navalesi, P., Voshaar, T., et al. (2011) · European Respiratory Journal · doi:10.1183/09031936.00166410 · Cited by 806
Device Selection and Outcomes of Aerosol Therapy: Evidence-Based Guidelines
Dolovich, M. B., Ahrens, R. C., Hess, D. R., Anderson, P., Dhand, R., Rau, J. L., Smaldone, G. C., & Guyatt, G. (2005) · Chest · doi:10.1378/chest.127.1.335 · Cited by 794
The Lungs as a Portal of Entry for Systemic Drug Delivery
Patton, J. S., Fishburn, C. S., & Weers, J. G. (2004) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200409-049ta · Cited by 563
Systematic Review of Errors in Inhaler Use
Sanchis, J., Gich, I., & Pedersen, S. (2016) · CHEST · doi:10.1016/j.chest.2016.03.041 · Cited by 538
Aerosol drug delivery: developments in device design and clinical use
Dolovich, M. B., & Dhand, R. (2011) · The Lancet · doi:10.1016/s0140-6736(10)60926-9 · Cited by 505
Medication adherence issues in patients treated for COPD
Restrepo, R. (2008) · International Journal of Chronic Obstructive Pulmonary Disease · doi:10.2147/copd.s3036 · Cited by 407
Inhaler competence in asthma: Common errors, barriers to use and recommended solutions
Price, D., Bosnic-Anticevich, S., Briggs, A., Chrystyn, H., Rand, C., Scheuch, G., & Bousquet, J. (2013) · Respiratory Medicine · doi:10.1016/j.rmed.2012.09.017 · Cited by 358
Barrier function of airway tract epithelium
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Metadata
- Authors
- Newman, S. P.
- Venue
- Therapeutic Delivery
- Publisher
- Informa UK Limited
- Published
- 2017-07
- Volume
- 8
- Issue
- 8
- Pages
- 647-661
- ISSN
- 2041-5990 (ISSN-L)
- 2041-6008
- OpenAlex
- W2738852352
- Cited by
- 328
- References
- 52
- FWCI
- 7.69
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
