The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Barrier function of airway tract epithelium
Open accessAbstract
Airway epithelium contributes significantly to the barrier function of airway tract. Mucociliary escalator, intercellular apical junctional complexes which regulate paracellular permeability and antimicrobial peptides secreted by the airway epithelial cells are the three primary components of barrier function of airway tract. These three components act cooperatively to clear inhaled pathogens, allergens and particulate matter without inducing inflammation and maintain tissue homeostasis. Therefore impairment of one or more of these essential components of barrier function may increase susceptibility to infection and promote exaggerated and prolonged innate immune responses to environmental factors including allergens and pathogens resulting in chronic inflammation. Here we review the regulation of components of barrier function with respect to chronic airways diseases.
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Citations
Cites
Defensins: antimicrobial peptides of innate immunity
Ganz, T. (2003) · Nature Reviews Immunology · doi:10.1038/nri1180 · Cited by 3,066
Mucus clearance as a primary innate defense mechanism for mammalian airways
Knowles, M. R., & Boucher, R. C. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215217 · Cited by 1,054
Qian, X., Karpova, T., Sheppard, A. M., McNally, J., & Lowy, D. R. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600136 · Cited by 396
Rhinovirus Disrupts the Barrier Function of Polarized Airway Epithelial Cells
Sajjan, U., Wang, Q., Zhao, Y., Gruenert, D. C., & Hershenson, M. B. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200801-136oc · Cited by 354
Self-citationEffective mucus clearance is essential for respiratory health
Randell, S. H., & Boucher, R. C. (2006) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2006-0082sf · Cited by 335 · cited 2×
“ASL is made up of two layers, an upper viscoelastic layer of mucins secreted by the goblet cells and submucosal glands,(50) which floats on a lower periciliary layer containing large membrane-bound glyocproteins, as well as tethered mucins (muc-1, muc-4 and muc-16).(51,52) The periciliary layer is relatively less visc…”
BackgroundAirway Mucus Obstruction: Mucin Glycoproteins, MUC Gene Regulation and Goblet Cell Hyperplasia
Rose, M. C., Nickola, T. J., & Voynow, J. A. (2001) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.25.5.f218 · Cited by 157
Zheng, S., De, B. P., Choudhary, S., Comhair, S. A. A., Goggans, T., Slee, R., Williams, B. R. G., Pilewski, J., Haque, S. J., & Erzurum, S. C. (2003) · Immunity · doi:10.1016/s1074-7613(03)00114-6 · Cited by 125
Cited by
Micro- and nanoplastic induced cellular toxicity in mammals: A review
Banerjee, A., & Shelver, W. L. (2021) · Science of The Total Environment · doi:10.1016/j.scitotenv.2020.142518 · Cited by 492
Dando, S. J., Mackay-Sim, A., Norton, R., Currie, B. J., St. John, J. A., Ekberg, J. A. K., Batzloff, M., Ulett, G. C., & Beacham, I. R. (2014) · Clinical Microbiology Reviews · doi:10.1128/cmr.00118-13 · Cited by 428
Drug Delivery to the lungs: Challenges and Opportunities
Newman, S. P. (2017) · Therapeutic Delivery · doi:10.4155/tde-2017-0037 · Cited by 328
Emerging Roles of Airway Epithelial Cells in Idiopathic Pulmonary Fibrosis
Chakraborty, A., Mastalerz, M., Ansari, M., Schiller, H. B., & Staab-Weijnitz, C. A. (2022) · Cells · doi:10.3390/cells11061050 · Cited by 68
Sato, T., Shimizu, T., Fujita, H., Imai, Y., Drucker, D. J., Seino, Y., & Yamada, Y. (2020) · Endocrinology · doi:10.1210/endocr/bqaa201 · Cited by 29
Metadata
- Authors
- Ganesan, S., Comstock, A. T., & Sajjan, U. S.
- Venue
- Tissue Barriers
- Publisher
- Informa UK Limited
- Published
- 2013-05-30
- Volume
- 1
- Issue
- 4
- Pages
- e24997
- ISSN
- 2168-8362 (ISSN-L)
- 2168-8370
- OpenAlex
- W2004014373
- Cited by
- 345
- References
- 7
- FWCI
- 8.57
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Ganesan, S., Comstock, A. T., & Sajjan, U. S. (2013). Barrier function of airway tract epithelium. Tissue Barriers. https://doi.org/10.4161/tisb.24997
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
