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Cited by 622Ovarian function and disordersDiabetes, Cardiovascular Risks, and LipoproteinsLipoproteins and Cardiovascular Health

Prevalence and predictors of dyslipidemia in women with polycystic ovary syndrome

Legro, Richard S, Kunselman, Allen R, Dunaif, Andrea·2001·The American Journal of Medicine
DOI 10.1016/s0002-9343(01)00948-2
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Abstract

Purpose Women with polycystic ovary syndrome are hyperandrogenemic and insulin resistant, which are associated with alterations in circulating lipid and lipoprotein levels. We sought to determine the prevalence of, and risk factors for, lipid abnormalities in these women.Subjects and methods Non-Hispanic white women with polycystic ovary syndrome (n = 195) and ethnically matched control women (n = 62) had fasting blood obtained for hormone and lipid levels. Subjects were categorized by body mass index (nonobese <27 kg/m(2), obese > or =27 kg/m(2)), and analyses were adjusted for age.Results Total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels increased significantly in obese women with polycystic ovary syndrome (n = 153) compared with obese control women (n = 35; mean difference in total cholesterol level = 29 mg/dL; 95% confidence interval [CI]: 14 to 45 mg/dL; P <0.001; mean difference in LDL-C level = 16 mg/dL; 95% CI: 4 to 30 mg/dL; P = 0.006). Similarly, total cholesterol and LDL-C levels increased significantly in nonobese women with polycystic ovary syndrome (n = 42) compared with nonobese control women (n = 27; mean difference in total cholesterol = 32 mg/dL; 95% CI: 13 to 52 mg/dL; P <0.001; mean difference in LDL-C level = 32 mg/dL; 95% CI: 15 to 52 mg/dL; P <0.001). In obese women, high-density lipoprotein cholesterol (HDL-C) and triglyceride levels increased significantly in women with polycystic ovary syndrome compared with control women (mean difference in HDL-C level = 6 mg/dL; 95% CI: 2 to 12 mg/dL; P = 0.002; mean difference in triglyceride level = 34 mg/dL; 95% CI: 1 to 77 mg/dL; P = 0.04). Differences in LDL-C and HDL-C levels, but not triglyceride levels, remained significant after adjusting for alcohol intake, smoking, and exercise. Although age, body mass index, and polycystic ovary syndrome status were significant predictors of lipid levels, these factors accounted for no more than 25% of the variance.Conclusions In this large study of non-Hispanic white women, elevations in LDL-C levels were the predominant lipid abnormality in women with polycystic ovary syndrome, independent of obesity. The characteristic dyslipidemia of insulin resistance was absent. Indeed, obese women with polycystic ovary syndrome had relatively elevated HDL-C levels, which may confer some protection against cardiovascular disease.

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Authors
Legro, R. S., Kunselman, A. R., & Dunaif, A.
Affiliations
  • Pennsylvania State University (US)
  • Brigham and Women's Hospital (US)
Corresponding author
Dunaif, Andrea
ORCID
Venue
The American Journal of Medicine
Publisher
Elsevier BV
Published
2001-12
Volume
111
Issue
8
Pages
607-613
ISSN
0002-9343 (ISSN-L)
DOI
10.1016/s0002-9343(01)00948-2
OpenAlex
W2021923144
Cited by
622
References
41
Citations by year
2026: 10 · 2025: 24 · 2024: 19 · 2023: 26 · 2022: 39 · 2021: 30 · 2020: 29 · 2019: 19 · 2018: 30 · 2017: 24 · 2016: 24 · 2015: 31 · 2014: 24 · 2013: 19 · 2012: 23
FWCI
17.16
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • The American Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK040605, DK-40605)
  • National Center for Research Resources (RR02635, M01RR010732, RR-10732, M01RR002635)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-34449, U54HD034449, HD-0118)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Keywords
polycystic ovary syndrome, dyslipidemia, hypercholesterolemia, hypertriglyceridemia, hyperandrogenism, insulin resistance, obesity, body mass index, LDL cholesterol, HDL cholesterol, triglycerides, lipid metabolism disorders, risk factors, women's health, alcohol consumption, smoking, non-Hispanic white women, ethnic differences
MeSH terms
Adolescent, Adult, Androgens, Blood Glucose, Cholesterol, Female, Humans, Hyperlipidemias, Insulin, Lipids, Middle Aged, Polycystic Ovary Syndrome, Predictive Value of Tests, Regression Analysis, Risk Factors, Triglycerides, Body Mass Index

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