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Cited by 115Infant Nutrition and HealthMicrobial Metabolites in Food BiotechnologyProbiotics and Fermented Foods

Prebiotics in infant formula

Open access
Vandenplas, Yvan, Greef, Elisabeth De, Veereman, Gigi·2014·Gut Microbes
DOI 10.4161/19490976.2014.972237PMC PMC4615227
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Abstract

The gastrointestinal microbiota of breast-fed babies differ from classic standard formula fed infants. While mother's milk is rich in prebiotic oligosaccharides and contains small amounts of probiotics, standard infant formula doesn't. Different prebiotic oligosaccharides are added to infant formula: galacto-oligosaccharides, fructo-oligosaccharide, polydextrose, and mixtures of these. There is evidence that addition of prebiotics in infant formula alters the gastrointestinal (GI) microbiota resembling that of breastfed infants. They are added to infant formula because of their presence in breast milk. Infants on these supplemented formula have a lower stool pH, a better stool consistency and frequency and a higher concentration of bifidobacteria in their intestine compared to infants on a non-supplemented standard formula. Since most studies suggest a trend for beneficial clinical effects, and since these ingredients are very safe, prebiotics bring infant formula one step closer to breastmilk, the golden standard. However, despite the fact that adverse events are rare, the evidence on prebiotics of a significant health benefit throughout the alteration of the gut microbiota is limited.

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  • Infants fed formula supplemented with B-GOS had increased abundance of Bifidobacterium and Lactobacillus compared to unsupplemented infants, similar to breastfed infants.

    “Infants fed formula supplemented with Bimuno-galactooligosaccharide (B-GOS®; Bimuno™, Clasado Biosciences Ltd, Buckinghamshire, UK), a proprietary product containing at least 65% GOS, had increased abundance of Bifidobacterium and Lactobacillus compared to unsupplemented infants, similar to levels reported in breastfed infants (Garrido et al., 2013;Vandenplas et al., 2014).”

    From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Vandenplas et al., 2014

    The Method section (page unavailable) reports that GOS-supplemented infant formula appears to stimulate bifidobacteria and lactobacilli similarly to human milk, and describes higher bifidobacteria counts than in controls. It does not identify the supplement as the proprietary B-GOS product or establish that this specific product produced both reported increases. (LLM, conf=0.86)

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Authors
Vandenplas, Y., Greef, E. D., & Veereman, G.
Affiliations
Vrije Universiteit Brussel (BE)
Corresponding author
Vandenplas, Yvan
ORCID
Venue
Gut Microbes
Publisher
Informa UK Limited
Published
2014-11-02
Volume
5
Issue
6
Pages
681-687
ISSN
  • 1949-0976 (ISSN-L)
  • 1949-0984
DOI
10.4161/19490976.2014.972237
PMC
PMC4615227
OpenAlex
W2049583931
Cited by
115
References
1
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FWCI
0.38
Type
journal article
Language
en
Open access
Locations
  • Gut Microbes (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • VUBIR (Vrije Universiteit Brussel) (submittedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
  • Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords
prebiotics, infant formula, prebiotic oligosaccharides, galactooligosaccharides, fructooligosaccharides, polydextrose, gut microbiota, breast milk, Bifidobacterium, stool consistency, infant formula supplementation
MeSH terms
Food Additives, Humans, Infant, Oligosaccharides, Infant Formula, Gastrointestinal Tract, Prebiotics, Microbiota

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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