Physiological and bifidogenic effects of prebiotic supplements in infant formulae

Veereman‐Wauters, G; Staelens, S; Van de Broek, H; Plaskie, K; Wesling, F; Roger, LC; McCartney, AL; Assam, P

doi:10.1097/mpg.0b013e3182139f39

Cited by 171Infant Nutrition and HealthMicrobial Metabolites in Food BiotechnologyProbiotics and Fermented Foods

Physiological and bifidogenic effects of prebiotic supplements in infant formulae

Veereman‐Wauters, G, Staelens, S, Van de Broek, H, Plaskie, K, Wesling, F, Roger, LC, McCartney, AL, Assam, P·2011·Journal of Pediatric Gastroenterology and Nutrition

DOI 10.1097/mpg.0b013e3182139f39

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Abstract

OBJECTIVES: This randomized controlled trial involving 110 healthy neonates studied physiological and bifidogenic effects of galactooligosaccharides (GOS), oligofructose, and long-chain inulin (fructooligosaccharides, FOS) in formula. METHODS: Subjects were randomized to Orafti Synergy1 (50 oligofructose:50 FOS) 0.4 g/dL or 0.8 g/dL, GOS:FOS (90:10) 0.8 g/dL, or a standard formula according to Good Clinical Practice guidelines. A breast-fed group was included for comparison. Outcome parameters were weight, length, intake, stool characteristics, crying, regurgitation, vomiting, adverse events, and fecal bacterial population counts. Statistical analyses used nonparametric tests. RESULTS: During the first month of life, weight, length, intake, and crying increased significantly in all of the groups. Regurgitation and vomiting scores were low and similar. Stool frequency decreased significantly and similarly in all of the formula groups but was lower than in the breast-fed group. All of the prebiotic groups maintained soft stools, only slightly harder than those of breast-fed infants. The standard group had significantly harder stools at weeks 2 and 4 compared with 1 (P < 0.001 and P = 0.0279). The total number of fecal bacteria increased in all of the prebiotic groups (9.82, 9.73, and 9.91 to 10.34, 10.38, and 10.37, respectively, log10 cells/g feces, P = 0.2298) and more closely resembled the breast-fed pattern. Numbers of lactic acid bacteria, bacteroides, and clostridia were comparable. In the SYN1 0.8 g/dL and GOS:FOS groups, Bifidobacterium counts were significantly higher at D14 and 28 compared with D3 and were comparable with the breast-fed group. Tolerance and growth were normal. CONCLUSIONS: Stool consistency and bacterial composition of infants taking SYN1 0.8 g/dL or GOS:FOS-supplemented formula were closer to the breast-fed pattern. There was no risk of dehydration.

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Infants fed oligosaccharide-enriched formulas have been shown to harbor greater numbers of bifidobacteria in feces.
“Oligosaccharide-enriched formulas have been developed, and infants fed these specialized formulas have been shown to harbor greater numbers of bifidobacteria in the feces 5,23.”
From Diet and the Intestinal Microbiome: Associations, Functions, and Implications for Health and Disease (2014) · cites this paper as [23]

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Authors: Veereman‐Wauters, G., Staelens, S., Van de Broek, H., Plaskie, K., Wesling, F., Roger, L., McCartney, A., & Assam, P.
Affiliations: Universitair Ziekenhuis Brussel (BE)
Department of Pediatric Gastroenterology and Nutrition Belgium
Department of Neonatology Belgium
Antwerp University Hospital (BE)
ZNA Middelheim Hospital (BE)
University of Reading (GB)
Hasselt University (BE)
Corresponding author: Staelens, S
Venue: Journal of Pediatric Gastroenterology and Nutrition
Publisher: Wiley
Published: 2011-06
Volume: 52
Issue: 6
Pages: 763-771
ISSN: 0277-2116 (ISSN-L)
1536-4801
DOI: 10.1097/mpg.0b013e3182139f39
OpenAlex: W2074114437
Cited by: 171
References: 39
Citations by year: 2026: 3 · 2025: 7 · 2024: 8 · 2023: 8 · 2022: 7 · 2021: 20 · 2020: 10 · 2019: 17 · 2018: 15 · 2017: 12 · 2016: 6 · 2015: 14 · 2014: 18 · 2013: 15 · 2012: 8
FWCI: 12.41
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Pediatric Gastroenterology and Nutrition (publishedVersion)
PubMed (publishedVersion)
Document Server@UHasselt (UHasselt) (submittedVersion)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords: prebiotics, infant formula, galactooligosaccharides, fructooligosaccharides, bifidogenic effect, Bifidobacterium, fecal microbiota, stool consistency, infant growth, regurgitation, neonates
MeSH terms: Bifidobacterium, Breast Feeding, Energy Intake, Crying, Defecation, Double-Blind Method, Feces, Food Microbiology, Growth, Humans, Infant, Infant, Newborn, Oligosaccharides, Prospective Studies, Vomiting, Dietary Supplements, Infant Formula, Gastrointestinal Tract, Prebiotics, Bacterial Load

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Physiological and bifidogenic effects of prebiotic supplements in infant formulae

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