New insights into adipose tissue VEGF-A actions in the control of obesity and insulin resistance

Obesity is associated with macrophage accumulation in adipose tissue

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Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

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Obesity induces a phenotypic switch in adipose tissue macrophage polarization

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Identification and Importance of Brown Adipose Tissue in Adult Humans

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Vascular Endothelial Growth Factor: Basic Science and Clinical Progress

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Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: Potential targets of anti-cancer therapy

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Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1

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Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction

Fantin, A., Vieira, J. M., Gestri, G., Denti, L., Schwarz, Q., Prykhozhij, S., Peri, F., Wilson, S. W., & Ruhrberg, C. (2010) · Blood · doi:10.1182/blood-2009-12-257832 · Cited by 1,153 · see citing works

VEGF-Induced Adult Neovascularization: Recruitment, Retention, and Role of Accessory Cells

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Hypoxia-Inducible Factor 1α Induces Fibrosis and Insulin Resistance in White Adipose Tissue

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Reduced Adipose Tissue Oxygenation in Human Obesity

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Biology of vascular endothelial growth factors

Roy, H., Bhardwaj, S., & Ylä‐Herttuala, S. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.03.087 · Cited by 537 · see citing works

Vascular endothelial growth factor B controls endothelial fatty acid uptake

Hagberg, C. E., Falkevall, A., Wang, X., Larsson, E., Huusko, J., Nilsson, I., van Meeteren, L. A., Samén, E., Lu, L., Vanwildemeersch, M., et al. (2010) · Nature · doi:10.1038/nature08945 · Cited by 508 · see citing works

The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues

Thangarajah, H., Yao, D., Chang, E. I.-F., Shi, Y., Jazayeri, L., Vial, I. N., Galiano, R. D., Du, X.-L., Grogan, R. H., Galvez, M. G., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906670106 · Cited by 469 · see citing works

Dichotomous effects of VEGF-A on adipose tissue dysfunction

Sun, K., Asterholm, I. W., Kusminski, C. M., Bueno, A. C., Wang, Z. V., Pollard, J. W., Brekken, R. A., & Scherer, P. E. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200447109 · Cited by 417 · see citing works

Hypoxia-Independent Angiogenesis in Adipose Tissues during Cold Acclimation

Xue, Y., Petrovič, N., Cao, R., Larsson, O. S., Lim, S., Chen, S., Feldmann, H. M., Liang, Z., Zhu, Z., Nedergaard, J., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2008.11.009 · Cited by 379 · see citing works

Human Brown Adipose Tissue

Enerbäck, S. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.03.008 · Cited by 367 · see citing works

Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation

Liu, Y., Berendsen, A. D., Jia, S., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci61209 · Cited by 356 · see citing works

Tumor-Associated Macrophage-Induced Invasion and Angiogenesis of Human Basal Cell Carcinoma Cells by Cyclooxygenase-2 Induction

Tjiu, J., Chen, J., Shun, C., Lin, S., Liao, Y., Chu, C., Tsai, T., Chiu, H., Dai, Y.-S., Inoue, H., et al. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.310 · Cited by 342 · see citing works

Angiogenic factors are elevated in overweight and obese individuals

Silha, J. V., Kršek, M., Sucharda, P., & Murphy, L. J. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0802987 · Cited by 338 · see citing works

Decreased Cardiac Expression of Vascular Endothelial Growth Factor and Its Receptors in Insulin-Resistant and Diabetic States

Chou, E. L., Suzuma, I., Way, K. J., Opland, D. M., Clermont, A. C., Naruse, K., Suzuma, K., Bowling, N. L., Vlahos, C. J., Aiello, L. P., et al. (2002) · Circulation · doi:10.1161/hc0302.102143 · Cited by 337 · see citing works

Adipose Tissue Overexpression of Vascular Endothelial Growth Factor Protects Against Diet-Induced Obesity and Insulin Resistance

Elias, I., Franckhauser, S., Ferré, T., Vilà, L., Tafuro, S., MUÑOZ, S. A., Roca, C., Ramos, D., Pujol, A., Riu, E., et al. (2012) · Diabetes · doi:10.2337/db11-0832 · Cited by 320 · see citing works

The chemokine CXCL12 regulates monocyte-macrophage differentiation and RUNX3 expression.

Sanchez-Martín, L., Estecha, A., Samaniego, R., Sánchez-Ramón, S., Vega, M. A., & Sánchez-Mateos, P. (2011) · Blood · doi:10.1182/blood-2009-12-258186 · Cited by 309 · see citing works

Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes

Hagberg, C. E., Mehlem, A., Falkevall, A., Muhl, L., Fam, B. C., Ortsäter, H., Scotney, P. D., Nyqvist, D., Samén, E., Li, L., et al. (2012) · Nature · doi:10.1038/nature11464 · Cited by 286 · see citing works

Gene expression profiling of cutaneous wound healing

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The multiple faces of CXCL12 (SDF-1α) in the regulation of immunity during health and disease

Karin, N. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.0909602 · Cited by 217 · see citing works

Vascular endothelial growth factor‐induced skin carcinogenesis depends on recruitment and alternative activation of macrophages

Linde, N., Lederle, W., Depner, S., van Rooijen, N., Gutschalk, C. M., & Mueller, M. M. (2012) · The Journal of Pathology · doi:10.1002/path.3989 · Cited by 195 · see citing works

CXCL12 (SDF-1α) suppresses ongoing experimental autoimmune encephalomyelitis by selecting antigen-specific regulatory T cells

Meiron, M., Zohar, Y., Anunu, R., Wildbaum, G., & Karin, N. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080730 · Cited by 169 · see citing works

The Implication of Brown Adipose Tissue for Humans

Ravussin, É., & Galgani, J. E. (2011) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-072610-145209 · Cited by 166 · see citing works

Obesity is associated with increased levels of circulating hepatocyte growth factor

Rehman, J., Considine, R. V., Bovenkerk, J. E., Li, J., Slavens, C. A., Jones, R. M., & March, K. L. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00231-6 · Cited by 160 · see citing works

Mechanisms underlying TGF-β1-induced expression of VEGF and Flk-1 in mouse macrophages and their implications for angiogenesis

Jeon, S.-H., Chae, B.-C., Kim, H.-A., Seo, G., Seo, D. W., Chun, G., Kim, N., Yie, S.-W., Byeon, W.-H., Eom, S., et al. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0806517 · Cited by 150 · see citing works

Bridges that guide and unite

Schmidt, T., & Carmeliet, P. (2010) · Nature · doi:10.1038/465697a · Cited by 105 · see citing works

Obesity-associated insulin resistance is correlated to adipose tissue vascular endothelial growth factors and metalloproteinase levels

Tinahones, F. J., Coín-Aragüez, L., Mayas, M. D., Garcia-Fuentes, E., Hurtado-del-Pozo, C., Vendrell, J., Cardona, F., Calvo, R.-M., Obregon, M.-J., & El Bekay, R. (2012) · BMC Physiology · doi:10.1186/1472-6793-12-4 · Cited by 95 · see citing works

Evidence for a Relationship between VEGF and BMI Independent of Insulin Sensitivity by Glucose Clamp Procedure in a Homogenous Group Healthy Young Men

Loebig, M., Klement, J., Schmoller, A., Betz, S., Heuck, N., Schweiger, U., Peters, A., Schultes, B., & Oltmanns, K. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012610 · Cited by 91 · see citing works

Maggot Secretions Skew Monocyte-Macrophage Differentiation Away from a Pro-Inflammatory to a Pro-Angiogenic Type

van der Plas, M. J. A., van Dissel, J. T., & Nibbering, P. H. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008071 · Cited by 89 · see citing works

Vascular Endothelial Growth Factor–Mediated Islet Hypervascularization and Inflammation Contribute to Progressive Reduction of β-Cell Mass

Agudo, J., Ayuso, E., Jiménez, V., et al. (2012) · Diabetes · doi:10.2337/db12-0134 · Cited by 89 · see citing works

Resistance to Obesity by Repression of VEGF Gene Expression through Induction of Brown-Like Adipocyte Differentiation

Lü, X., Ji, Y., Zhang, L., Zhang, Y., Zhang, S., An, Y., Liu, P., & Zheng, Y. (2012) · Endocrinology · doi:10.1210/en.2012-1151 · Cited by 70 · see citing works

Partners in crime: VEGF and IL‐4 conscript tumour‐promoting macrophages

Palma, M. D. (2012) · The Journal of Pathology · doi:10.1002/path.4008 · Cited by 32 · see citing works

New genetic loci link adipose and insulin biology to body fat distribution

The ADIPOGen Consortium, Shungin, D., The CARDIOGRAMplusC4D Consortium, The CKDGen Consortium, The GEFOS Consortium, The GENIE Consortium, The, G. L. G. C., The, I. C. B. P., The International Endogene Consortium, Study, T. L. C., et al. (2015) · Nature · doi:10.1038/nature14132 · Cited by 1,580 · see citing works

The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis.

Crewe, C., An, Y. A., & Scherer, P. E. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88883 · Cited by 732 · see citing works

Brown Adipose Tissue: More Than an Effector of Thermogenesis?a

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Do estrogens enhance activation of brown and beiging of adipose tissues?

Frank, A. P., Palmer, B. F., & Clegg, D. J. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.09.026 · Cited by 37 · see citing works

Application limitations of sympathetic nerve-mediated thermogenesis of brown/ beige adipose tissue in the treatment of obesity

Ma, D., Jiang, P., & Wang, Y. (2017) · Zhonghua neifenmi daixie zazhi · doi:10.3760/cma.j.issn.1000-6699.2017.07.018

Brown Adipose Tissue as a Therapeutic Target

Lichtenbelt, W. D. V. M., & Nascimento, E. B. M. (2017) · Springer eBooks · doi:10.1007/978-3-319-52031-5_9

Brown adipose tissue lipoprotein and glucose disposal is not determined by thermogenesis in uncoupling protein 1-deficient mice

Fischer, A. W., Behrens, J. R., Sass, F., Schlein, C., Heine, M., Pertzborn, P., Scheja, L., & Heeren, J. (2020) · Journal of Lipid Research · doi:10.1194/jlr.ra119000455 · Cited by 21 · see citing works