The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Autophagy promotes resistance to photodynamic therapy-induced apoptosis selectively in colorectal cancer stem-like cells
Open accessAbstract
Recent studies have indicated that cancer stem-like cells (CSCs) exhibit a high resistance to current therapeutic strategies, including photodynamic therapy (PDT), leading to the recurrence and progression of colorectal cancer (CRC). In cancer, autophagy acts as both a tumor suppressor and a tumor promoter. However, the role of autophagy in the resistance of CSCs to PDT has not been reported. In this study, CSCs were isolated from colorectal cancer cells using PROM1/CD133 (prominin 1) expression, which is a surface marker commonly found on stem cells of various tissues. We demonstrated that PpIX-mediated PDT induced the formation of autophagosomes in PROM1/CD133(+) cells, accompanied by the upregulation of autophagy-related proteins ATG3, ATG5, ATG7, and ATG12. The inhibition of PDT-induced autophagy by pharmacological inhibitors and silencing of the ATG5 gene substantially triggered apoptosis of PROM1/CD133(+) cells and decreased the ability of colonosphere formation in vitro and tumorigenicity in vivo. In conclusion, our results revealed a protective role played by autophagy against PDT in CSCs and indicated that targeting autophagy could be used to elevate the PDT sensitivity of CSCs. These findings would aid in the development of novel therapeutic approaches for CSC treatment.
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Cites
Tumour stem cells and drug resistance
Dean, M., Fojo, T., & Bates, S. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1590 · Cited by 3,668
The Atg12-Atg5 Conjugate Has a Novel E3-like Activity for Protein Lipidation in Autophagy
Hanada, T., Noda, N. N., Satomi, Y., Ichimura, Y., Fujioka, Y., Takao, T., Inagaki, F., & Ohsumi, Y. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.c700195200 · Cited by 1,123 · cited 1×
“ATG3 and ATG5 are both essential regulatory components of autophagosome biogenesis.(61,62) A recent report shows that ATG3 degradation by CASP8 could lead to autophagy inactivation during receptor-triggered apoptosis.”
ABCG2-mediated transport of photosensitizers: Potential impact on photodynamic therapy
Robey, R. W., Steadman, K., Polgar, O., & Bates, S. E. (2005) · Cancer Biology & Therapy · doi:10.4161/cbt.4.2.1440 · Cited by 204
Improvement of Tumor Response by Manipulation of Tumor Oxygenation During Photodynamic Therapy¶
Chen, Q., Huang, Z., Chen, H., Shapiro, H., Beckers, J., & Hetzel, F. W. (2007) · Photochemistry and Photobiology · doi:10.1562/0031-8655(2002)0760197iotrbm2.0.co2 · Cited by 124
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Overcoming barriers in photodynamic therapy harnessing nano-formulation strategies
Xie, J., Wang, Y., Choi, W., Jangili, P., Ge, Y., Xu, Y., Kang, J., Liu, L., Zhang, B., Xie, Z., et al. (2021) · Chemical Society Reviews · doi:10.1039/d0cs01370f · Cited by 522
Nanoagent‐Promoted Mild‐Temperature Photothermal Therapy for Cancer Treatment
Gao, G., Sun, X., & Liang, G. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202100738 · Cited by 359
Activating autophagy to potentiate immunogenic chemotherapy and radiation therapy
Galluzzi, L., Bravo-San Pedro, J. M., Demaria, S., Formenti, S. C., & Kroemer, G. (2017) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2016.183 · Cited by 314
Bretin, L., Pinon, A., Bouramtane, S., Ouk, C., Richard, L., Perrin, M.-L., Chaunavel, A., Carrion, C., Bregier, F., Sol, V., et al. (2019) · Cancers · doi:10.3390/cancers11101474 · Cited by 62
Susceptibility and Resistance Mechanisms During Photodynamic Therapy of Melanoma
Li, X.-Y., Tan, L.-C., Dong, L.-W., Zhang, W.-Q., Shen, X.-X., Lu, X., Zheng, H., & Lu, Y.-G. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00597 · Cited by 55
Metadata
- Authors
- Wei, M.-F., Chen, M.-W., Chen, K.-C., Lou, P.-J., Lin, S. Y.-F., Hung, S.-C., Hsiao, M., Yao, C.-J., & Shieh, M.-J.
- Venue
- Autophagy
- Publisher
- Informa UK Limited
- Published
- 2014-04-29
- Volume
- 10
- Issue
- 7
- Pages
- 1179-1192
- ISSN
- 1554-8627 (ISSN-L)
- 1554-8635
- OpenAlex
- W2034050926
- Cited by
- 205
- References
- 4
- FWCI
- 13.26
- Type
- journal article
- Language
- en
- Open access
- hybrid
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