The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Molecular mechanisms and physiological significance of autophagy during myocardial ischemia and reperfusion
Open accessAbstract
Autophagy is an intracellular bulk degradation process whereby cytoplasmic proteins and organelles are degraded and recycled through lysosomes. In the heart, autophagy plays a homeostatic role at basal levels, and the absence of autophagy causes cardiac dysfunction and the development of cardiomyopathy. Autophagy is induced during myocardial ischemia and further enhanced by reperfusion. Although induction of autophagy during the ischemic phase is protective, further enhancement of autophagy during the reperfusion phase may induce cell death and appears to be detrimental. In this review we discuss the functional significance of autophagy and the underlying signaling mechanism in the heart during ischemia/reperfusion.
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Cites
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Loss of autophagy in the central nervous system causes neurodegeneration in mice
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Apoptosis in the Failing Human Heart
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Cited by
Kalogeris, T., Baines, C. P., Krenz, M., & Korthuis, R. J. (2016) · Comprehensive Physiology · doi:10.1002/cphy.c160006 · Cited by 718
Oxidative Stress and Pathophysiology of Ischemic Stroke: Novel Therapeutic Opportunities
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The Role of Autophagy in the Heart
Sciarretta, S., Maejima, Y., Zablocki, D., & Sadoshima, J. (2018) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021317-121427 · Cited by 547
Self-citationMolecular machinery and interplay of apoptosis and autophagy in coronary heart disease
Dong, Y., Chen, H., Gao, J., Liu, Y., Li, J., & Wang, J. (2019) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2019.09.001 · Cited by 438
FoxO Transcription Factors Promote Autophagy in Cardiomyocytes
Sengupta, A., Molkentin, J. D., & Yutzey, K. E. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.024406 · Cited by 428
Metadata
- Authors
- Matsui, Y., Kyoi, S., Takagi, H., Hsu, C.-P., Hariharan, N., Ago, T., Vatner, S. F., & Sadoshima, J.
- Venue
- Autophagy
- Publisher
- Informa UK Limited
- Published
- 2008-05-16
- Volume
- 4
- Issue
- 4
- Pages
- 409-415
- ISSN
- 1554-8627 (ISSN-L)
- 1554-8635
- OpenAlex
- W1972557061
- Cited by
- 187
- References
- 15
- FWCI
- 6.35
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Matsui, Y., Kyoi, S., Takagi, H., Hsu, C.-P., Hariharan, N., Ago, T., Vatner, S. F., & Sadoshima, J. (2008). Molecular mechanisms and physiological significance of autophagy during myocardial ischemia and reperfusion. Autophagy. https://doi.org/10.4161/auto.5638
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