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Anti-cancer agent siramesine is a lysosomotropic detergent that induces cytoprotective autophagosome accumulation

Ostenfeld, Marie Stampe, Høyer-Hansen, Maria, Bastholm, Lone, Fehrenbacher, Nicole, Olsen, Ole Dines, Groth-Pedersen, Line, Puustinen, Pietri, Kirkegaard-Sørensen, Thomas, Nylandsted, Jesper, Farkas, Thomas, Jäättelä, Marja·2008·Autophagy
DOI 10.4161/auto.5774
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  • Some small molecule modulators of S2R, such as siramesine and SV119, trigger the induction of autophagy, while other S2R modulators such as CT2168 can restore α-synuclein oligomer-induced deficits in lysosomal-associated membrane protein 2A levels back to healthy control levels in neurons.

    “Some small molecule modulators of S2R, such as siramesine and SV119, trigger the induction of autophagy [118,120], while other S2R modulators such as CT2168 can restore α-synuclein oligomer-induced deficits in lysosomal-associated membrane protein 2A levels, an indirect marker of autophagy, back to healthy control levels in neurons [4].”

    From Sigma-2 Receptors—From Basic Biology to Therapeutic Target: A Focus on Age-Related Degenerative Diseases (2023) · cites this paper as [120]

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Research works printed but not linked: 45

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Metadata

Authors
Ostenfeld, M. S., Høyer-Hansen, M., Bastholm, L., Fehrenbacher, N., Olsen, O. D., Groth-Pedersen, L., Puustinen, P., Kirkegaard-Sørensen, T., Nylandsted, J., Farkas, T., & Jäättelä, M.
Venue
Autophagy
Publisher
Informa UK Limited
Published
2008-05-16
Volume
4
Issue
4
Pages
487-499
ISSN
  • 1554-8627
  • 1554-8635
DOI
10.4161/auto.5774
Cited by
142
References
0
Language
en

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