The pharmacology of sigma-1 receptors.

Control of inositol 1,4,5-trisphosphate-induced Ca2+ release by cytosolic Ca2+

Bootman, M. D., Missiaen, L., Parys, J. B., SMEDT, H. D., & Casteels, R. (1995) · Biochemical Journal · doi:10.1042/bj3060445 · Cited by 5,120 · see citing works

The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.

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Sigma-1 Receptor Chaperones at the ER- Mitochondrion Interface Regulate Ca2+ Signaling and Cell Survival

Hayashi, T., & Su, T.-P. (2007) · Cell · doi:10.1016/j.cell.2007.08.036 · Cited by 1,826 · see citing works

How Cells Handle Cholesterol

Simons, K., & Ikonen, E. (2000) · Science · doi:10.1126/science.290.5497.1721 · Cited by 1,277 · see citing works

Purification, molecular cloning, and expression of the mammalian sigma1-binding site.

Hanner, M., Moebius, F. F., Flandorfer, A., Knaus, H. G., Striessnig, J., Kempner, E. S., & Glossmann, H. H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.15.8072 · Cited by 906 · see citing works

Brain circuitry and the reinstatement of cocaine-seeking behavior

Kalivas, P., & McFarland, K. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1393-2 · Cited by 613 · see citing works

Steroid Binding at σ Receptors Suggests a Link Between Endocrine, Nervous, and Immune Systems

Su, T., London, E. D., & Jaffe, J. H. (1988) · Science · doi:10.1126/science.2832949 · Cited by 548 · see citing works

The Hallucinogen <i>N,N</i> -Dimethyltryptamine (DMT) Is an Endogenous Sigma-1 Receptor Regulator

Fontanilla, D., Johannessen, M., Hajipour, A. R., Cozzi, N. V., Jackson, M. B., & Ruoho, A. E. (2009) · Science · doi:10.1126/science.1166127 · Cited by 535 · see citing works

Sigma-1 and sigma-2 receptors are expressed in a wide variety of human and rodent tumor cell lines.

Vilner, B. J., John, C. S., & Bowen, W. D. (1995) · PubMed · Cited by 484 · see citing works

Rat liver and kidney contain high densities of σ1 and σ2 receptors: characterization by ligand binding and photoaffinity labeling

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Evidence for sigma opioid receptor: binding of [3H]SKF-10047 to etorphine-inaccessible sites in guinea-pig brain.

Su, T.-P. (1982) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)33330-6 · Cited by 435 · see citing works

The Sigma Receptor as a Ligand-Regulated Auxiliary Potassium Channel Subunit

Aydar, E., Palmer, C. P., Klyachko, V. A., & Jackson, M. B. (2002) · Neuron · doi:10.1016/s0896-6273(02)00677-3 · Cited by 400 · see citing works

Beneficial effects of L-arginine on reducing obesity: potential mechanisms and important implications for human health

McKnight, J. R., Satterfield, M. C., Jobgen, W. S., Smith, S. B., Spencer, T. E., Meininger, C. J., McNeal, C. J., & Wu, G. (2010) · Amino Acids · doi:10.1007/s00726-010-0598-z · Cited by 376 · see citing works

Regulating ankyrin dynamics: Roles of sigma-1 receptors

Hayashi, T., & Su, T. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.491 · Cited by 331 · see citing works

Simian Virus 40 Depends on ER Protein Folding and Quality Control Factors for Entry into Host Cells

Schelhaas, M., Malmström, J. A., Pelkmans, L., Haugstetter, J., Ellgaard, L., Grünewald, K., & Helenius, A. (2007) · Cell · doi:10.1016/j.cell.2007.09.038 · Cited by 300 · see citing works

Sigma1 (σ1) receptor agonists and neurosteroids attenuate β25–35-amyloid peptide-induced amnesia in mice through a common mechanism

Maurice, T., Su, T., & Privat, A. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00405-3 · Cited by 291 · see citing works

Cloning and Functional Characterization of a σ Receptor from Rat Brain

Seth, P., Fei, Y.-J., Li, H. W., Huang, W. Y., Leibach, F. H., & Ganapathy, V. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70030922.x · Cited by 290 · see citing works

The anti‐amnesic and neuroprotective effects of donepezil against amyloid β25‐35peptide‐induced toxicity in mice involve an interaction with theσ1receptor

Meunier, J., Ieni, J. R., & Maurice, T. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706927 · Cited by 289 · see citing works

σ-1 Receptors (σ1 Binding Sites) Form Raft-Like Microdomains and Target Lipid Droplets on the Endoplasmic Reticulum: Roles in Endoplasmic Reticulum Lipid Compartmentalization and Export

Hayashi, T., & Su, T.-P. (2003) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.051284 · Cited by 262 · see citing works

Interactions of selective serotonin reuptake inhibitors with subtypes of σ receptors in rat brain

Narita, N., Hashimoto, K., Tomitaka, S.-I., & Minabe, Y. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(96)00254-3 · Cited by 254 · see citing works

Effective Tumor Cell Death by σ-2 Receptor Ligand Siramesine Involves Lysosomal Leakage and Oxidative Stress

Ostenfeld, M. S., Fehrenbacher, N., Høyer-Hansen, M. H., Thomsen, C., Farkas, T., & Jäättelä, M. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0269 · Cited by 250 · see citing works

Sigma-2 receptor agonists activate a novel apoptotic pathway and potentiate antineoplastic drugs in breast tumor cell lines.

Crawford, K. W., & Bowen, W. D. (2002) · PubMed · Cited by 241 · see citing works

Sigma receptors: biology and therapeutic potential

Guitart, X., Codony, X., & Monroy, X. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1920-9 · Cited by 235 · see citing works

N-methyl-D-aspartate-induced neuronal activation is selectively modulated by σ receptors

Monnet, F. P., Debonnel, G., Junien, J., & de Montigny, C. (1990) · European Journal of Pharmacology · doi:10.1016/0014-2999(90)90186-a · Cited by 233 · see citing works

Association of polymorphism of serotonin 2A receptor gene with suicidal ideation in major depressive disorder

Du, L., Bakish, D., Lapierre, Y. D., Ravindran, A. V., & Hrdina, P. D. (2000) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(20000207)96:1 · Cited by 229 · see citing works

The interaction between neuroactive steroids and the σ1 receptor function: behavioral consequences and therapeutic opportunities

Maurice, T., Urani, A., Phan, V., & Romieu, P. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00112-6 · Cited by 223 · see citing works

Neuroprotective and anti-amnesic potentials of sigma (σ) receptor ligands

Maurice, T., & Lockhart, B. P. (1997) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(96)00160-1 · Cited by 211 · see citing works

Cocaine binding at σ receptors

Sharkey, J., Glen, K. A., Wolfe, S. A., & Kuhar, M. J. (1988) · European Journal of Pharmacology · doi:10.1016/0014-2999(88)90058-1 · Cited by 205 · see citing works

Naltrexone fails to antagonize the σ effects of PCP and SKF 10,047 in the dog

Vaupel, D. B. (1983) · European Journal of Pharmacology · doi:10.1016/0014-2999(83)90297-2 · Cited by 195 · see citing works

Animal models of Alzheimer's disease and evaluation of anti-dementia drugs

Yamada, K., & Nabeshima, T. (2000) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(00)00081-4 · Cited by 191 · see citing works

Intracellular Dynamics of σ-1 Receptors (σ1 Binding Sites) in NG108-15 Cells

Hayashi, T., & Su, T. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.051292 · Cited by 189 · see citing works

The sigma‐1 receptor modulates NMDA receptor synaptic transmission and plasticity via SK channels in rat hippocampus

Martina, M., B.‐Turcotte, M., Halman, S., & Bergeron, R. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.116178 · Cited by 187 · see citing works

The antidepressant-like effect induced by sigma(1)-receptor agonists and neuroactive steroids in mice submitted to the forced swimming test.

Urani, A., Roman, F. J., Phan, V. L., Su, T., & Maurice, T. (2001) · PubMed · Cited by 181 · see citing works

Neuroactive Neurosteroids as Endogenous Effectors for the Sigma1 (.SIGMA.1) Receptor. Pharmacological Evidence and Therapeutic Opportunities.

Maurice, T., Phan, V.-L., Urani, A., Kamei, H., Noda, Y., & Nabeshima, T. (1999) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.81.125 · Cited by 179 · see citing works

Intracellular sigma1 receptor modulates phospholipase C and protein kinase C activities in the brainstem.

Morin-Surun, M., Collin, T., Denavit-Saubié, M., Baulieu, E., & Monnet, F. (1999) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.96.14.8196 · Cited by 176 · see citing works

Low density of sigma1 receptors in early Alzheimer’s disease

Mishina, M., Ohyama, M., Ishii, K., Kitamura, S., Kimura, Y., Oda, K.-I., Kawamura, K., Sasaki, T., Kobayashi, S., Katayama, Y., et al. (2008) · Annals of Nuclear Medicine · doi:10.1007/s12149-007-0094-z · Cited by 172 · cited 1× · see citing works

Sigma Receptors Inhibit High-Voltage–Activated Calcium Channels in Rat Sympathetic and Parasympathetic Neurons

Zhang, H., & Cuevas, J. (2002) · Journal of Neurophysiology · doi:10.1152/jn.2002.87.6.2867 · Cited by 171 · see citing works

The Sigma1 Protein as a Target for the Non-genomic Effects of Neuro(active)steroids: Molecular, Physiological, and Behavioral Aspects

Monnet, F. P., & Maurice, T. (2006) · Journal of Pharmacological Sciences · doi:10.1254/jphs.cr0050032 · Cited by 167 · see citing works

Small Molecule Antagonists of the σ-1 Receptor Cause Selective Release of the Death Program in Tumor and Self-Reliant Cells and Inhibit Tumor Growth in Vitro and in Vivo

Spruce, B. A., Campbell, L. A., McTavish, N., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3180 · Cited by 166 · see citing works

Sigma-1 receptor knockout mice display a depressive-like phenotype

Sabino, V., Cottone, P., Parylak, S., Steardo, L., & Zorrilla, E. P. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.11.036 · Cited by 164 · see citing works

Anti-cancer agent siramesine is a lysosomotropic detergent that induces cytoprotective autophagosome accumulation

Ostenfeld, M. S., Høyer-Hansen, M. H., Bastholm, L., Fehrenbacher, N., Olsen, O. D., Groth‐Pedersen, L., Puustinen, P., Kirkegaard‐Sørensen, T., Nylandsted, J., Farkas, T., et al. (2008) · Autophagy · doi:10.4161/auto.5774 · Cited by 160 · see citing works

σ Receptors: potential medications development target for anti-cocaine agents

Matsumoto, R. R., Liu, Y., Lerner, M. R., Howard, E. W., & Brackett, D. J. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01723-0 · Cited by 159 · see citing works

Sigma1 (σ1) receptor antagonists represent a new strategy against cocaine addiction and toxicity

Maurice, T., Martin‐Fardon, R., Romieu, P., & Matsumoto, R. R. (2002) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(02)00017-9 · Cited by 153 · see citing works

Sigma-1 Receptors Bind Cholesterol and Remodel Lipid Rafts in Breast Cancer Cell Lines

Palmer, C. P., Mahen, R., Schnell, E., Djamgoz, M. B. A., & Aydar, E. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-1771 · Cited by 148 · see citing works

Involvement of sigma (σ) receptors in the acute actions of methamphetamine: Receptor binding and behavioral studies

Nguyen, E. C., McCracken, K. A., Liu, Y., Pouw, B., & Matsumoto, R. R. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.04.016 · Cited by 146 · see citing works

The Role of Sigma Receptors in Depression

Bermack, J. E., & Debonnel, G. (2005) · Journal of Pharmacological Sciences · doi:10.1254/jphs.crj04005x · Cited by 142 · see citing works

Overexpression of sigma receptors in nonneural human tumors.

Bem, W. T., Thomas, G. E., Mamone, J. Y., Homan, S. M., Levy, B. K., Johnson, F. E., & Coscia, C. J. (1991) · PubMed · Cited by 142 · see citing works

Formalin-induced pain is reduced in σ1 receptor knockout mice

Cendán, C. M., Pujalte, J. M., Portillo-Salido, E. F., Montoliu, L., & Baeyens, J. M. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.01.036 · Cited by 141 · see citing works

Phencyclidine-Induced Cognitive Deficits in Mice are Improved by Subsequent Subchronic Administration of Fluvoxamine: Role of Sigma-1 Receptors

Hashimoto, K., Fujita, Y., & Iyo, M. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301047 · Cited by 136 · see citing works

Role of Sigma-1 Receptor C-terminal Segment in Inositol 1,4,5-Trisphosphate Receptor Activation

Wu, Z., & Bowen, W. D. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802099200 · Cited by 135 · see citing works

ς1 Receptor Modulation of Opioid Analgesia in the Mouse

Mei, J., & Pasternak, G. W. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.300.3.1070 · Cited by 132 · see citing works

Intrathecal Injection of the ς1Receptor Antagonist BD1047 Blocks Both Mechanical Allodynia and Increases in Spinal NR1 Expression during the Induction Phase of Rodent Neuropathic Pain

Roh, D., Kim, H., Yoon, S. Y., Seo, H.-S., Kwon, Y., Kim, K.-W., Han, H. J., Beitz, A. J., Na, H.-S., & Lee, J. (2008) · Anesthesiology · doi:10.1097/aln.0b013e3181895a83 · Cited by 128 · see citing works

PRE-084, a σ selective PCP derivative, attenuates MK-801-induced impairment of learning in mice

Maurice, T., Su, T., Parish, D. W., Nabeshima, T., & Privat, A. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90235-6 · Cited by 128 · see citing works

Spreading Depression: Imaging and Blockade in the Rat Neocortical Brain Slice

Anderson, T. R., & Andrew, R. D. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00321.2002 · Cited by 126 · see citing works

Dehydroepiandrosterone sulfate attenuates dizocilpine-induced learning impairment in mice via σ1-receptors

Maurice, T., Junien, J., & Privat, A. (1997) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)86061-5 · Cited by 124 · see citing works

Molecular cloning and pharmacological characterization of the rat sigma1 receptor11Abbreviations: DTG, N,N′-di(o-tolyl-guanidine); HA, hemagglutinin; RT-PCR, reverse transcriptase-polymerase chain reaction; RACE, rapid amplification of cDNA ends; and CHO, Chinese hamster ovary.

Mei, J., & Pasternak, G. W. (2001) · Biochemical Pharmacology · doi:10.1016/s0006-2952(01)00666-9 · Cited by 123 · see citing works

Anxiolytic- and antidepressant-like profile of a new CRF1 receptor antagonist, R278995/CRA0450

Chaki, S., Nakazato, A., Kennis, L. E. J., Nakamura, M., Mackie, C. E., Sugiura, M., Vinken, P., ASHTON, D. S., Langlois, X., & Steckler, T. (2003) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2003.11.032 · Cited by 123 · see citing works

Activation of the spinal sigma‐1 receptor enhances NMDA‐induced pain via PKC‐ and PKA‐dependent phosphorylation of the NR1 subunit in mice

Kim, H., Roh, D., Yoon, S., Seo, H., Kwon, Y., Han, H. J., Kim, K.-W., Beitz, A. J., & Lee, J. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.159 · Cited by 121 · see citing works

Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity

Marrazzo, A., Caraci, F., Salinaro, E. T., Su, T., Copani, A., & Ronsisvalle, G. (2005) · Neuroreport · doi:10.1097/00001756-200508010-00018 · Cited by 120 · see citing works

Involvement of the Sigma1 Receptor in Cocaine-induced Conditioned Place Preference Possible Dependence on Dopamine Uptake Blockade

Romieu, P. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00391-8 · Cited by 119 · see citing works

The expression and functional characterization of sigma (σ) 1 receptors in breast cancer cell lines

Aydar, E., Onganer, P. U., Perrett, R. M., Djamgoz, M. B. A., & Palmer, C. P. (2006) · Cancer Letters · doi:10.1016/j.canlet.2005.11.011 · Cited by 117 · see citing works

Sigma Receptor Activation Reduces Infarct Size at 24 Hours After Permanent Middle Cerebral Artery Occlusion in Rats

Ajmo, C. T., Vernon, D. O. L., Collier, L. A., Pennypacker, K. R., & Cuevas, J. (2006) · Current Neurovascular Research · doi:10.2174/156720206776875849 · Cited by 116 · see citing works

Sigma-1 Receptor Activation Prevents Intracellular Calcium Dysregulation in Cortical Neurons during in Vitro Ischemia

Katnik, C. P., Guerrero, W. R., Pennypacker, K. R., Herrera, Y., & Cuevas, J. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.107557 · Cited by 115 · see citing works

In Vivo Protection against Retinal Neurodegeneration by Sigma Receptor 1 Ligand (+)-Pentazocine

Smith, S. B., Duplantier, J., Dun, Y., et al. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-1824 · Cited by 112 · see citing works

Membrane‐delimited coupling between sigma receptors and K+ channels in rat neurohypophysial terminals requires neither G‐protein nor ATP

Lupardus, P. J., Wilke, R. A., Aydar, E., Palmer, C. P., Chen, Y., Ruoho, A. E., & Jackson, M. B. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00527.x · Cited by 111 · see citing works

When the Endogenous Hallucinogenic Trace AmineN,N-Dimethyltryptamine Meets the Sigma-1 Receptor

Su, T., Hayashi, T., & Vaupel, D. B. (2009) · Science Signaling · doi:10.1126/scisignal.261pe12 · Cited by 110 · see citing works

Involvement of the σ1 receptor in the cocaine-induced conditioned place preference

Romieu, P., Martin‐Fardon, R., & Maurice, T. (2000) · Neuroreport · doi:10.1097/00001756-200009110-00011 · Cited by 107 · see citing works

Antiamnesic and Neuroprotective Effects of the Aminotetrahydrofuran Derivative ANAVEX1-41 Against Amyloid β25–35-Induced Toxicity in Mice

Villard, V., Espallergues, J., Keller, E., Alkam, T., Nitta, A., Yamada, K., Nabeshima, T., Vamvakides, A., & Maurice, T. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.212 · Cited by 105 · see citing works

Loss of sigma binding sites in the CA1 area of the anterior hippocampus in Alzheimer's disease correlates with CA1 pyramidal cell loss

Jansen, K. L. R., Faull, R. L. M., Storey, P., & Leslie, R. A. (1993) · Brain Research · doi:10.1016/0006-8993(93)91441-t · Cited by 103 · see citing works

Involvement of sigma receptors in the behavioral effects of cocaine: evidence from novel ligands and antisense oligodeoxynucleotides

Matsumoto, R. R., McCracken, K. A., Pouw, B., Zhang, Y., & Bowen, W. D. (2002) · Neuropharmacology · doi:10.1016/s0028-3908(02)00056-4 · Cited by 103 · see citing works

Increase in extracellular acetylcholine level by sigma ligands in rat frontal cortex.

Matsuno, K., Matsunaga, K., Senda, T., & Mita, S. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)38212-1 · Cited by 100 · see citing works

The Antidepressant-Like Effect Induced by ς1-Receptor Agonists and Neuroactive Steroids in Mice Submitted to the Forced Swimming Test

Urani, A., Roman, F. J., Phan, V., Su, T., & Maurice, T. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29502-1 · Cited by 100 · see citing works

Intrathecal treatment withσ1receptor antagonists reduces formalin‐induced phosphorylation of NMDA receptor subunit 1 and the second phase of formalin test in mice

Kim, H., Kwon, Y., Roh, D., et al. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706764 · Cited by 99 · see citing works

SA4503, a novel cognitive enhancer with σ1 receptor agonist properties, facilitates NMDA receptor-dependent learning in mice

Maurice, T., & Privat, A. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)83020-8 · Cited by 96 · see citing works

4-IBP, a σ1 Receptor Agonist, Decreases the Migration of Human Cancer Cells, Including Glioblastoma Cells, In Vitro and Sensitizes Them In Vitro and In Vivo to Cytotoxic Insults of Proapoptotic and Proautophagic Drugs

Mégalizzi, V., Mathieu, V., Mijatovic, T., Gailly, P. L., Debeir, O., Nève, N. D., Damme, M. V., Bontempi, G., Haibe‐Kains, B., Decaestecker, C., et al. (2007) · Neoplasia · doi:10.1593/neo.07130 · Cited by 95 · see citing works

TAK-147, an acetylcholinesterase inhibitor, increases choline acetyltransferase activity in cultured rat septal cholinergic neurons

Kato, K., Hayako, H., Ishihara, Y., et al. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00943-4 · Cited by 94 · see citing works

σ-1 Receptors Protect RGC-5 Cells from Apoptosis by Regulating Intracellular Calcium, Bax Levels, and Caspase-3 Activation

Tchedre, K. T., & Yorio, T. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-1101 · Cited by 94 · see citing works

σ-1 Receptor Modulation of Acid-Sensing Ion Channel a (ASIC1a) and ASIC1a-Induced Ca2+ Influx in Rat Cortical Neurons

Herrera, Y., Katnik, C. P., Rodriguez, J. D., Hall, A. A., Willing, A. E., Pennypacker, K. R., & Cuevas, J. (2008) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.143974 · Cited by 94 · see citing works

Sigma 1 receptor-related neuroactive steroids modulate cocaine-induced reward.

Romieu, P., Martin‐Fardon, R., Bowen, W. D., & Maurice, T. (2003) · PubMed Central · doi:10.1523/jneurosci.23-09-03572.2003 · Cited by 92 · see citing works

Cancer Cell Cycle Modulated by a Functional Coupling between Sigma-1 Receptors and Cl– Channels

Renaudo, A., L’Hoste, S., Guizouarn, H., Borgèse, F., & Soriani, O. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607915200 · Cited by 91 · see citing works

Prevention of Excitotoxicity in Primary Retinal Ganglion Cells by (+)-Pentazocine, a Sigma Receptor-1–Specific Ligand

Dun, Y., Thangaraju, M., Prasad, P. D., et al. (2007) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-0343 · Cited by 85 · see citing works

σ‐1 Receptors potentiate epidermal growth factor signaling towards neuritogenesis in PC12 cells: Potential relation to lipid raft reconstitution

Takebayashi, M., Hayashi, T., & Su, T. (2004) · Synapse · doi:10.1002/syn.20041 · Cited by 84 · see citing works

σ Receptor Activation Blocks Potassium Channels and Depresses Neuroexcitability in Rat Intracardiac Neurons

Zhang, H., & Cuevas, J. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.084152 · Cited by 84 · see citing works

Modulation of serotonergic neurotransmission by short‐ and long‐term treatments with sigma ligands

Bermack, J. E., & Debonnel, G. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704294 · Cited by 83 · see citing works

Expression pattern of sigma receptor 1 mRNA and protein in mammalian retina

Ola, M. S., Moore, P., El-Sherbeny, A., Roon, P., Agarwal, N. A., Sarthy, V. P., Casellas, P., Ganapathy, V., & Smith, S. B. (2001) · Molecular Brain Research · doi:10.1016/s0169-328x(01)00249-2 · Cited by 83 · see citing works

Enhanced κ-opioid receptor-mediated analgesia by antisense targeting the σ1 receptor

King, M., Pan, Y., Mei, J., et al. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)01064-9 · Cited by 82 · see citing works

Biochemical and functional evidence for the control of pain mechanisms by dehydroepiandrosterone endogenously synthesized in the spinal cord

Kibaly, C., Meyer, L., Patte‐Mensah, C., & Mensah‐Nyagan, A. G. (2007) · The FASEB Journal · doi:10.1096/fj.07-8930com · Cited by 82 · see citing works

Beneficial Effects of Acute and Repeated Administrations of σ Receptor Agonists on Behavioral Despair in Mice Exposed to Tail Suspension

Ukai, M., Maeda, H., Yoshihisa, N., Kameyama, T., & Matsuno, K. (1998) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(98)00093-8 · Cited by 82 · see citing works

Neuroprotective Effect of σ1-Receptor Ligand 4-Phenyl-1-(4-Phenylbutyl) Piperidine (PPBP) Is Linked to Reduced Neuronal Nitric Oxide Production

Goyagi, T., Goto, S., Bhardwaj, A., et al. (2001) · Stroke · doi:10.1161/01.str.32.7.1613 · Cited by 82 · see citing works

Cocaine-induced HIV-1 expression in microglia involves sigma-1 receptors and transforming growth factor-β1

Gekker, G., Hu, S., Sheng, W. S., Rock, R. B., Lokensgard, J. R., & Peterson, P. K. (2006) · International Immunopharmacology · doi:10.1016/j.intimp.2005.12.005 · Cited by 80 · see citing works

The sigma receptor ligand (+)−pentazocine prevents apoptotic retinal ganglion cell death induced in vitro by homocysteine and glutamate

Martin, P. M., Ola, M. S., Agarwal, N. A., et al. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2003.12.019 · Cited by 80 · see citing works

σ2 Receptors regulate changes in sphingolipid levels in breast tumor cells

Crawford, K. W., Coop, A., & Bowen, W. D. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01581-9 · Cited by 80 · see citing works

Interaction with σ1 Protein, but Not N-Methyl-d-aspartate Receptor, Is Involved in the Pharmacological Activity of Donepezil

Maurice, T., Meunier, J., Feng, B., et al. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.097394 · Cited by 80 · see citing works

Regulating ankyrin dynamics: Roles of sigma-1 receptors

Hayashi, T. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.021413698 · Cited by 80 · see citing works

The sigma1 (?1) receptor activation is a key step for the reactivation of cocaine conditioned place preference by drug priming

Romieu, P., Meunier, J., Garcia, D., Zozime, N., Martin-Fardon, R., Bowen, W. D., & Maurice, T. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1814-x · Cited by 79 · see citing works

Sigma Receptors: Chemistry, Cell Biology And Clinical Implications

Matsumoto, R. R. (2007) · Medical Entomology and Zoology · Cited by 78 · see citing works

Dimemorfan protects rats against ischemic stroke through activation of sigma‐1 receptor‐mediated mechanisms by decreasing glutamate accumulation

Shen, Y., Wang, Y., Chou, Y., et al. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05058.x · Cited by 78 · see citing works

Cocaine and σ-1 receptors modulate HIV infection, chemokine receptors, and the HPA axis in the huPBL-SCID model

Roth, M. D., Whittaker, K., Choi, R., et al. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.0405219 · Cited by 78 · see citing works

Sigma Receptor Agonists Provide Neuroprotection In Vitro by Preserving bcl-2

Yang, S., Bhardwaj, A., Cheng, J., Alkayed, N. J., Hurn, P. D., & Kirsch, J. R. (2007) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000260267.71185.73 · Cited by 77 · see citing works

Sigma1 receptor upregulation after chronic methamphetamine self-administration in rats: a study with yoked controls

Stefański, R., Justinová, Z., Hayashi, T., Takebayashi, M., Goldberg, S. R., & Su, T. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1779-9 · Cited by 76 · see citing works

Protein Kinase C-Dependent Potentiation of Intracellular Calcium Influx by σ1 Receptor Agonists in Rat Hippocampal Neurons

Monnet, F. P., Morin-Surun, M. P., Leger, J., & Combettes, L. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.053447 · Cited by 74 · see citing works

Sigma Receptor Photolabeling and Sigma Receptor-mediated Modulation of Potassium Channels in Tumor Cells

Wilke, R. A., Mehta, R. P., Lupardus, P. J., Chen, Y., Ruoho, A. E., & Jackson, M. B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.26.18387 · Cited by 71 · see citing works

Haloperidol-associated Stealth Liposomes

Mukherjee, A., Prasad, T. K., Rao, N. M., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m409723200 · Cited by 70 · see citing works

Differential Effects of σ1 Receptor Blockade on Self-Administration and Conditioned Reinstatement Motivated by Cocaine vs Natural Reward

Martin‐Fardon, R., Maurice, T., Aujla, H., Bowen, W. D., & Weiss, F. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301323 · Cited by 70 · see citing works

Expression of sigma 1 receptor in human breast cancer

Wang, B., Rouzier, R., Albarracin, C. T., Şahin, A. A., Wagner, P., Yang, Y., Smith, T. L., Meric‐Bernstam, F., Aldaz, C. M., Hortobágyi, G. N., et al. (2004) · Breast Cancer Research and Treatment · doi:10.1007/s10549-004-6590-0 · Cited by 69 · see citing works

Modification of the N-methyl-D-aspartate response by antidepressant σ receptor ligands

Bergeron, R., Debonnel, G., & de Montigny, C. (1993) · European Journal of Pharmacology · doi:10.1016/0014-2999(93)90918-8 · Cited by 68 · see citing works

Neurosteroids and σ1Receptors, Biochemical and Behavioral Relevance

Maurice, T. (2004) · Pharmacopsychiatry · doi:10.1055/s-2004-832675 · Cited by 68 · see citing works

Highly selective σ receptor ligands elevate inositol 1,4,5-trisphosphate production in rat cardiac myocytes

Novàkovâ, M., Ela, C., Bowen, W. D., et al. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00398-7 · Cited by 68 · see citing works

Evidence for an anti-amnesic effect of JO 1784 in the rat: a potent and selective ligand for the sigma receptor

Earley, B., Burke, M. G., Leonard, B. E., Gouret, C.-J., & Junien, J. (1991) · Brain Research · doi:10.1016/0006-8993(91)91492-j · Cited by 68 · see citing works

Association between polymorphisms in the type 1 sigma receptor gene and schizophrenia

Ishiguro, H., Ohtsuki, T., Toru, M., Itokawa, M., Aoki, J., Shibuya, H., Kurumaji, A., Okubo, Y., Iwawaki, A., Ota, K., et al. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00797-6 · Cited by 68 · see citing works

Neurosteroid dehydroepiandrosterone sulphate inhibits persistent sodium currents in rat medial prefrontal cortex via activation of sigma-1 receptors

Cheng, Z., Lan, D.-M., Wu, P., Zhu, Y., Dong, Y. W., Ma, L., & Zheng, P. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.10.004 · Cited by 67 · see citing works

DHEA-Neuroprotection and -Neurotoxicity after Transient Cerebral Ischemia in Rats

Li, Z., Cui, S., Zhang, Z., Zhou, R., Ge, Y., Sokabe, M., & Chen, L. (2008) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2008.118 · Cited by 66 · see citing works

Binding of dimemorfan to sigma-1 receptor and its anticonvulsant and locomotor effects in mice, compared with dextromethorphan and dextrorphan

Chou, Y., Liao, J., Chang, W.-Y., Lin, M.-F., & Chen, C. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01125-7 · Cited by 66 · see citing works

Clinical Trials with Sigma Ligands

Volz, H., & Stoll, K.-D. (2004) · Pharmacopsychiatry · doi:10.1055/s-2004-832680 · Cited by 66 · see citing works

The Sigma Receptor Ligand, Reduced Haloperidol, Induces Apoptosis and Increases Intracellular-Free Calcium Levels [Ca2+]iin Colon and Mammary Adenocarinoma Cells

Brent, P. J., Pang, G., Little, G., et al. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.0208 · Cited by 65 · see citing works

Involvement of the sigma1 receptor in the motivational effects of ethanol in mice

Maurice, T., Casalino, M., Lacroix, M., & Romieu, P. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00002-9 · Cited by 62 · see citing works

Involvement of σ1 receptors in methamphetamine-induced behavioral sensitization in rats

Takahashi, S., Miwa, T., & Horikomi, K. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01258-1 · Cited by 61 · see citing works

Sigma 1 Receptor Agonists Act as Neuroprotective Drugs Through Inhibition of Inducible Nitric Oxide Synthase

Vagnerova, K., Hurn, P. D., Bhardwaj, A., & Kirsch, J. R. (2006) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000226133.85114.91 · Cited by 61 · see citing works

Inhibition of Tumor Cell Proliferation by σ Ligands Is Associated with K+ Channel Inhibition and p27kip1 Accumulation

Renaudo, A., Watry, V., Chassot, A., Ponzio, G., Ehrenfeld, J., & Soriani, O. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.072413 · Cited by 59 · see citing works

Steroid pregnenolone sulfate enhances NMDA‐receptor‐independent long‐term potentiation at hippocampal CA1 synapses: Role for L‐type calcium channels and sigma‐receptors

Sabeti, J., Nelson, T. E., Purdy, R. H., & Gruol, D. L. (2007) · Hippocampus · doi:10.1002/hipo.20273 · Cited by 58 · see citing works

Modulation of Brainstem Opiate Analgesia in the Rat by σ1 Receptors: A Microinjection Study

Mei, J., & Pasternak, G. W. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.121137 · Cited by 56 · see citing works

A Variant of the Sigma Receptor Type-1 Gene Is a Protective Factor for Alzheimer Disease

Uchida, N., Ujike, H., Tanaka, Y., Sakai, A., Yamamoto, M., Fujisawa, Y., Kanzaki, A., & Kuroda, S. (2005) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200512000-00005 · Cited by 56 · see citing works

Chronic administration of dehydroepiandrosterone sulfate (DHEAS) primes for facilitated induction of long-term potentiation via sigma 1 (σ1) receptor: Optical imaging study in rat hippocampal slices

Chen, L., Dai, X., & Sokabe, M. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.10.015 · Cited by 54 · see citing works

Further evidence for an antidepressant potential of the selective σ1 agonist SA 4503: electrophysiological, morphological and behavioural studies

Lucas, G., Rymar, V. V., Sadikot, A. F., & Debonnel, G. (2008) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708008547 · Cited by 54 · see citing works

Effects of σ1 receptor agonist SA4503 and neuroactive steroids on performance in a radial arm maze task in rats

Zou, L.-B., Yamada, K., Sasa, M., Nakata, Y., & NABESHIMA, T. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(99)00228-2 · Cited by 54 · see citing works

Differential involvement of the sigma1 (σ1) receptor in the anti‐amnesic effect of neuroactive steroids, as demonstrated using an in vivo antisense strategy in the mouse

Maurice, T., Phan, V., Urani, A., & Guillemain, I. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704355 · Cited by 53 · see citing works

Cocaine Up-Regulates Fra-2 and σ-1 Receptor Gene and Protein Expression in Brain Regions Involved in Addiction and Reward

Liu, Y., Chen, G., Lerner, M. R., Brackett, D. J., & Matsumoto, R. R. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.084525 · Cited by 51 · see citing works

True

Simony-Lafontaine, J., Esslimani, M., Lequeux, N., et al. (2000) · British Journal of Cancer · doi:10.1054/bjoc.2000.1162 · Cited by 50 · see citing works

σ1-Receptor Ligand 4-Phenyl-1-(4-Phenylbutyl)-Piperidine Affords Neuroprotection From Focal Ischemia With Prolonged Reperfusion

Harukuni, I., Bhardwaj, A., Shaivitz, A. B., DeVries, A. C., London, E. D., Hurn, P. D., Traystman, R. J., & Kirsch, J. R. (2000) · Stroke · doi:10.1161/01.str.31.4.976 · Cited by 50 · see citing works

A-Current down-modulated by sigma receptor in frog pituitary melanotrope cells through a G protein-dependent pathway.

Soriani, O., Foll, F. L., Roman, F. J., Monnet, F. P., Vaudry, H., & Cazin, L. (1999) · PubMed · Cited by 50 · see citing works

Modulation of the firing activity of female dorsal raphe nucleus serotonergic neurons by neuroactive steroids

Robichaud, M., & Debonnel, G. (2004) · Journal of Endocrinology · doi:10.1677/joe.0.1820011 · Cited by 49 · see citing works

Beneficial effect of the σ1 receptor agonist PRE-084 against the spatial learning deficits in aged rats

Maurice, T. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01436-4 · Cited by 48 · see citing works

Ligand-dependent localization and intracellular stability of sigma-1 receptors in CHO-K1 ce

Mavlyutov, T. A., & Ruoho, A. E. (2007) · Journal of Molecular Signaling · doi:10.1186/1750-2187-2-8 · Cited by 48 · see citing works

Haloperidol induces apoptosis via the σ2 receptor system and Bcl-XS

Wei, Z., Mousseau, D. D., Dai, Y., Cao, X., & Xm, L. (2006) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500373 · Cited by 48 · see citing works

Distinct modulatory roles of sigma receptor subtypes on glutamatergic responses in the dorsal hippocampus

Bermack, J. E., & Debonnel, G. (2004) · Synapse · doi:10.1002/syn.20085 · Cited by 47 · see citing works

Alterations in Fos-Related Antigen 2 and σ1 Receptor Gene and Protein Expression Are Associated with the Development of Cocaine-Induced Behavioral Sensitization: Time Course and Regional Distribution Studies

Liu, Y., & Matsumoto, R. R. (2008) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.141051 · Cited by 47 · see citing works

IL-10 Mediates Sigma1 Receptor-Dependent Suppression of Antitumor Immunity

Zhu, L. X., Sharma, S. P., Gardner, B. K., Escuadro, B., Atianzar, K., Tashkin, D. P., & Dubinett, S. M. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.7.3585 · Cited by 46 · see citing works

Intrathecal administration of sigma‐1 receptor agonists facilitates nociception: Involvement of a protein kinase C–dependent pathway

Roh, D., Kim, H., Yoon, S., et al. (2008) · Journal of Neuroscience Research · doi:10.1002/jnr.21802 · Cited by 45 · see citing works

Dehydroepiandrosterone sulfate prevents ischemia-induced impairment of long-term potentiation in rat hippocampal CA1 by up-regulating tyrosine phosphorylation of NMDA receptor

Li, Z., Zhou, R., Cui, S., Xie, G., Cai, W., Sokabe, M., & Chen, L. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.06.007 · Cited by 41 · see citing works

Functional polymorphisms in the sigma1 receptor gene associated with alcoholism

Miyatake, R., Furukawa, A., Matsushita, S., Higuchi, S., & Suwaki, H. (2003) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.07.008 · Cited by 41 · see citing works

Interactions between 3,4-methylenedioxymethamphetamine and σ1 receptors

Brammer, M. K., Gilmore, D. L., & Matsumoto, R. R. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.09.038 · Cited by 40 · see citing works

Cocaine modulates cytokine and enhances tumor growth through sigma receptors

Gardner, B. K., Zhu, L. X., Roth, M. D., et al. (2003) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2003.10.020 · Cited by 40 · see citing works

Enhanced antidepressant efficacy of σ1 receptor agonists in rats after chronic intracerebroventricular infusion of β-amyloid-(1–40) protein

Urani, A., Romieu, P., Roman, F. J., Yamada, K., Noda, Y., Kamei, H., Tran, H. M., Nagai, T., Nabeshima, T., & Maurice, T. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2003.12.018 · Cited by 38 · see citing works

Involvement of the Sigma1Receptor in the Appetitive Effects of Cocaine

Maurice, T., & Romieu, P. (2004) · Pharmacopsychiatry · doi:10.1055/s-2004-832678 · Cited by 37 · see citing works

A potential antidepressant activity of SA4503, a selective σ1 receptor agonist

Skuza, G., & Rogóż, Z. (2002) · Behavioural Pharmacology · doi:10.1097/00008877-200211000-00003 · Cited by 37 · see citing works

Enhanced antidepressant effect of sigma1 (σ1) receptor agonists in β25–35-amyloid peptide-treated mice

Urani, A., Romieu, P., Roman, F. J., & Maurice, T. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00033-5 · Cited by 37 · see citing works

Novel ceramide analogues display selective cytotoxicity in drug-resistant breast tumor cell lines compared to normal breast epithelial cells.

Kw, C., Bittman, R., Chun, J., et al. (2003) · PubMed · Cited by 37 · see citing works

Sigma Receptor Type 1 Gene Variation in a Group of Polish Patients with Alzheimer’s Disease and Mild Cognitive Impairment

Maruszak, A., Safranow, K., Gacia, M., Gabryelewicz, T., Słowik, A., Styczyńska, M., Pepłońska, B., Golan, M. P., Żekanowski, C., & Barcikowska, M. (2007) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000101990 · Cited by 36 · see citing works

Antiamnesic and Neuroprotective Effects of Donepezil against Learning Impairments Induced in Mice by Exposure to Carbon Monoxide Gas

Meunier, J., Ieni, J. R., & Maurice, T. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.101527 · Cited by 35 · see citing works

Beneficial effects of the sigma1 receptor agonists igmesine and dehydroepiandrosterone against learning impairments in rats prenatally exposed to cocaine

Meunier, J., & Maurice, T. (2004) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2004.07.003 · Cited by 34 · see citing works

Involvement of the sigma1(σ1) receptor in the anti‐amnesic, but not antidepressant‐like, effects of the aminotetrahydrofuran derivative ANAVEX1‐41

Espallergues, J., Lapalud, P., Christopoulos, A., Avlani, V. A., Sexton, P. M., Vamvakides, A., & Maurice, T. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707386 · Cited by 33 · see citing works

Efficacy and Safety of the Sigma Receptor Ligand EMD 57445 (Panamesine) in Patients with Schizophrenia: an Open Clinical Trial

Huber, M., Gotthardt, U., Schreiber, W., et al. (1999) · Pharmacopsychiatry · doi:10.1055/s-2007-979194 · Cited by 33 · see citing works

Fluvoxamine as a sigma-1 receptor agonist improved cognitive impairments in a patient with schizophrenia

Iyo, M., Shirayama, Y., Watanabe, H., et al. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.01.005 · Cited by 32 · see citing works

Protective effects of the sigma agonist Pre-084 in the rat retina

Cantarella, G., Bucolo, C., Benedetto, G. D., et al. (2007) · British Journal of Ophthalmology · doi:10.1136/bjo.2007.118570 · Cited by 32 · see citing works

Possible involvement of sigma‐1 receptors in the anti‐immobility action of bupropion, a dopamine reuptake inhibitor

Dhir, A., & Kulkarni, S. K. (2008) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2008.00605.x · Cited by 32 · see citing works

Sigma Receptor Antagonists Inhibit Human Lens Cell Growth and Induce Pigmentation

Wang, L., Prescott, A. R., Spruce, B. A., et al. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.04-1209 · Cited by 30 · see citing works

The ς-ligand (+)-pentazocine depresses M current and enhances calcium conductances in frog melanotrophs

Soriani, O., Foll, F. L., Galas, L., et al. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.1.e73 · Cited by 30 · see citing works

Emergence of NMDAR‐independent long‐term potentiation at hippocampal CA1 synapses following early adolescent exposure to chronic intermittent ethanol: Role for sigma‐receptors

Sabeti, J., & Gruol, D. L. (2007) · Hippocampus · doi:10.1002/hipo.20379 · Cited by 29 · see citing works

Sigma1 receptor antagonists attenuate antidepressant-like effect induced by co-administration of 1,3 di-o-tolylguanidine (DTG) and memantine in the forced swimming test in rats.

Skuza, G., & Rogóż, Z. (2003) · PubMed · Cited by 29 · see citing works

Olfactory bulbectomy increases prepro-enkephalin mRNA levels in the ventral striatum in rats

Holmes, P. V. (1999) · Neuropeptides · doi:10.1054/npep.1999.0031 · Cited by 28 · see citing works

Sigma1 receptor antagonists determine the behavioral pattern of the methamphetamine-induced stereotypy in mice

Kitanaka, J., Kitanaka, N., Tatsuta, T., Hall, F. S., Uhl, G. R., Tanaka, K., Nishiyama, N., Morita, Y., & Takemura, M. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1425-z · Cited by 27 · see citing works

Anti‐amnesic effect of dimemorfan in mice

Wang, H., Chien, J., Chou, Y., Liao, J., & Chen, C. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705117 · Cited by 27 · see citing works

A-Current Down-Modulated by ς Receptor in Frog Pituitary Melanotrope Cells Through a G Protein-Dependent Pathway

Soriani, O., Foll, F. L., Roman, F. J., Monnet, F. P., Vaudry, H., & Cazin, L. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38139-x · Cited by 27 · see citing works

No association between the sigma receptor type 1 gene and schizophrenia: results of analysis and meta-analysis of case-control studies

Uchida, N., Ujike, H., Nakata, K., Takaki, M., Nomura, A., Katsu, T., Tanaka, Y., Imamura, T., Sakai, A., & Kuroda, S. (2003) · BMC Psychiatry · doi:10.1186/1471-244x-3-13 · Cited by 25 · see citing works

A new sigma ligand, (±)-PPCC, antagonizes kappa opioid receptor-mediated antinociceptive effect

Prezzavento, O., Parenti, C., Marrazzo, A., et al. (2008) · Life Sciences · doi:10.1016/j.lfs.2007.11.032 · Cited by 25 · see citing works

HIF-1α contributes to tumour-selective killing by the sigma receptor antagonist rimcazole

Achison, M., Boylan, M. T., Hupp, T. R., & Spruce, B. A. (2006) · Oncogene · doi:10.1038/sj.onc.1209890 · Cited by 25 · see citing works

A Variant of the Sigma Receptor Type-1 Gene Is a Protective Factor for Alzheimer Disease

Uchida, N. (2005) · American Journal of Geriatric Psychiatry · doi:10.1176/appi.ajgp.13.12.1062 · Cited by 25 · see citing works

Potent ς1-Receptor Ligand 4-Phenyl-1-(4-Phenylbutyl) Piperidine Provides Ischemic Neuroprotection Without Altering Dopamine Accumulation In Vivo in Rats

Goyagi, T., Bhardwaj, A., Koehler, R. C., et al. (2003) · Anesthesia & Analgesia · doi:10.1097/00000539-200302000-00043 · Cited by 24 · see citing works

Effects of sigma receptor agonists on the impairment of spontaneous alternation behavior and decrease of cyclic GMP level induced by nitric oxide synthase inhibitors in mice

Mamiya, T., Noda, Y., Noda, A., et al. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(00)00078-2 · Cited by 23 · see citing works

A novel adamantane derivative attenuates retinal ischemia–reperfusion damage in the rat retina through σ1 receptors

Bucolo, C., Marrazzo, A., Ronsisvalle, S., et al. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.02.026 · Cited by 21 · see citing works

A placebo-controlled trial of igmesine in the treatment of major depression

Pande, A. C., Genève, J., Scherrer, B., Smith, F., Leadbetter, R. A., & MEYNARD, C. D. (1999) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(99)80011-x · Cited by 19 · see citing works

Effects of the Potential Antidepressant OPC-14523 [1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2-quinolinone Monomethanesulfonate] a Combined σ and 5-HT1A Ligand: Modulation of Neuronal Activity in the Dorsal Raphe Nucleus

Bermack, J. E., Haddjeri, N., & Debonnel, G. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.066472 · Cited by 17 · see citing works

No Association Found between the Type 1 Sigma Receptor Gene Polymorphisms and Methamphetamine Abuse in the Japanese Population: A Collaborative Study by the Japanese Genetics Initiative for Drug Abuse

Inada, T., Iijima, Y., Uchida, N., Maeda, T., IWASHITA, S., Ozaki, N., Harano, M., KOMIYAMA, T., Yamada, M., Sekine, Y., et al. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1316.003 · Cited by 16 · see citing works

Effects of sigma ligands on NMDA receptor function in the bulbectomy model of depression: a behavioural study in the rat

Bermack, J. E., Lavoie, N., Dryver, E. T., & Debonnel, G. (2002) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145701002760 · Cited by 16 · see citing works

Effects of OPC-14523, a combined sigma and 5-HT 1a ligand, on pre- and post-synaptic 5-HT 1a receptors

Bermack, J. E., & Debonnel, G. (2006) · Journal of Psychopharmacology · doi:10.1177/0269881106063996 · Cited by 14 · see citing works

Potent ς1-Receptor Ligand 4-Phenyl-1-(4-Phenylbutyl) Piperidine Provides Ischemic Neuroprotection Without Altering Dopamine Accumulation In Vivo in Rats

Goyagi, T., Bhardwaj, A., Koehler, R. C., et al. (2003) · Anesthesia & Analgesia · doi:10.1213/00000539-200302000-00043 · Cited by 14 · see citing works

Lack of association between sigma1 receptor gene variants and schizophrenia

SATOH, F., Miyatake, R., Furukawa, A., et al. (2004) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2004.01268.x · Cited by 12 · see citing works

Neuroactive Steroids Protect Retinal Tissue through σ1 Receptors

Bucolo, C., & Drago, F. (2007) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2007.00044.x · Cited by 7 · see citing works

A variant of the sigma receptor type 1 gene is a protective factor for Alzheimer's disease

内田, 有. (2006) · Medical Entomology and Zoology · Cited by 2 · see citing works

Robichaud, M. & Debonnel, G. Modulation of the firing activity of female dorsal raphe nucleus serotonergic neurons by neuroactive steroids. J. Endocrinol. 182, 11-21

Robichaud, M., & Debonnel, G. (2004) · Cited by 2 · see citing works

Silencing of sigma-1 receptor induces cell death in human lens cells

Wang, L., & Duncan, G. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2006.01.004

Crystal structure of the human σ1 receptor

Schmidt, H. R., Zheng, S., Gurpinar, E., Koehl, A., Manglik, A., & Kruse, A. C. (2016) · Nature · doi:10.1038/nature17391 · Cited by 482 · see citing works

Depression and cardiac disease: epidemiology, mechanisms, and diagnosis.

Huffman, J. C., Celano, C. M., Beach, S. R., Motiwala, S. R., & Januzzi, J. L. (2013) · Cardiovascular Psychiatry and Neurology · doi:10.1155/2013/695925 · Cited by 445 · see citing works

Sigma-1 receptor chaperone at the ER-mitochondrion interface mediates the mitochondrion-ER-nucleus signaling for cellular survival.

Mori, T., Hayashi, T., Hayashi, E., & Su, T.-P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076941 · Cited by 317 · see citing works

The sigma-1 receptor: roles in neuronal plasticity and disease

Kourrich, S., Su, T.-P., Fujimoto, M., & Bonci, A. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.09.007 · Cited by 245 · see citing works

The therapeutic potentials of Ayahuasca: possible effects against various diseases of civilization

Frecska, E., Bokor, P., & Winkelman, M. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00035 · Cited by 242 · see citing works

Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanisms

Inserra, A., De Gregorio, D., & Gobbi, G. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000056 · Cited by 232 · see citing works

Psychedelic N,N-Dimethyltryptamine and 5-Methoxy-N,N-Dimethyltryptamine Modulate Innate and Adaptive Inflammatory Responses through the Sigma-1 Receptor of Human Monocyte-Derived Dendritic Cells

Szabo, A., Kovacs, A., Frecska, E., & Rajnavolgyi, E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106533 · Cited by 191 · see citing works

The sigma-1 receptor protects against cellular oxidative stress and activates antioxidant response elements.

Pal, A., Fontanilla, D., Gopalakrishnan, A., Chae, Y.-K., Markley, J. L., & Ruoho, A. E. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.01.030 · Cited by 177 · see citing works

Anti-amnesic and neuroprotective potentials of the mixed muscarinic receptor/sigma ₁ (σ ₁ ) ligand ANAVEX2-73, a novel aminotetrahydrofuran derivative

Villard, V., Espallergues, J., Keller, E., Vamvakides, A., & Maurice, T. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881110379286 · Cited by 139 · see citing works

The endogenous hallucinogen and trace amine N.N-dimethyltryptamine (DMT) displays potent protective effects against hypoxia via sigma-1 receptor activation in human primary iPSC-derived cortical neurons and microglia-like immune cells

Szabo, A., Kovacs, A., Riba, J., Djurovic, S., Rajnavolgyi, E., & Frecska, E. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00423 · Cited by 121 · see citing works

Dark Classics in Chemical Neuroscience: 3,4-Methylenedioxymethamphetamine

Dunlap, L. E., Andrews, A. M., & Olson, D. E. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00155 · Cited by 106 · see citing works

Structural basis for human sterol isomerase in cholesterol biosynthesis and multidrug recognition

Long, T., Hassan, A., Thompson, B. M., McDonald, J. G., Wang, J., & Li, X. (2019) · Nature Communications · doi:10.1038/s41467-019-10279-w · Cited by 65 · see citing works

Sigma-1 Receptor Expression in Sensory Neurons and the Effect of Painful Peripheral Nerve Injury

Bangaru, M. L., Weihrauch, D., Tang, Q.-B., Zoga, V., Hogan, Q., & Wu, H.-E. (2013) · Molecular Pain · doi:10.1186/1744-8069-9-47 · Cited by 62 · see citing works

Mutational Analysis of Sigma-1 Receptor’s Role in Synaptic Stability

Ryskamp, D. A., Zhemkov, V., & Bezprozvanny, I. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01012 · Cited by 21 · see citing works

Modulation of Cellular Calcium by Sigma-2 Receptors: Release from Intracellular Stores in Human SK-N-SH Neuroblastoma Cells

Vilner, B. J., & Bowen, W. D. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)35369-8 · Cited by 198 · see citing works

The Sigma Receptor: Evolution of the Concept in Neuropsychopharmacology

HAYASHI, T., & Su, T. (2005) · Current Neuropharmacology · doi:10.2174/157015905774322516 · Cited by 154 · see citing works

The Sigma 2 receptor promotes and the Sigma 1 receptor inhibits mu-opioid receptor-mediated antinociception

Sánchez‐Blázquez, P., Cortés‐Montero, E., Rodríguez-Muñoz, M., Merlos, M., & Garzón-Niño, J. (2020) · Molecular Brain · doi:10.1186/s13041-020-00676-4 · Cited by 23 · see citing works

A perspective on the new mechanism of antidepressants: neuritogenesis through sigma-1 receptors.

Takebayashi, M., Hayashi, T., & Su, T.-P. (2004) · Pharmacopsychiatry · doi:10.1055/s-2004-832679 · Cited by 77 · see citing works

Use of N-ethylmaleimide to directly determine the proportion of β-adrenergic receptors exhibiting high affinity for agonists on human mononuclear leukocyte membranes

Rigby, J. W., & Wood, A. J. J. (1989) · Biochemical Pharmacology · doi:10.1016/0006-2952(89)90428-0 · Cited by 1 · see citing works