Lysosomal cell death at a glance

Lysosomotropic Agents

De Duve, C., De Barsy, T., Poole, B., Trouet, A., Tulkens, P., & Van Hoof, F. (1974) · Biochemical Pharmacology · doi:10.1016/0006-2952(74)90174-9 · Cited by 1,901 · see citing works

Lysosomal membrane permeabilization in cell death

Boya, P., & Kroemer, G. (2008) · Oncogene · doi:10.1038/onc.2008.310 · Cited by 1,425 · see citing works

Cysteine cathepsins: From structure, function and regulation to new frontiers

Turk, V., Stoka, V., Vasiljeva, O., Renko, M., Sun, T., Turk, B., & Turk, D. (2012) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2011.10.002 · Cited by 1,377 · see citing works

Lysosomes and autophagy in cell death control

Kroemer, G., & Jäättelä, M. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1738 · Cited by 1,291 · see citing works

Cathepsin B contributes to TNF-α–mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c

Guicciardi, M. E., Deussing, J. M., Miyoshi, H., Bronk, S. F., Svingen, P. A., Peters, C., Kaufmann, S. H., & Gores, G. J. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9914 · Cited by 710 · see citing works

At the acidic edge: emerging functions for lysosomal membrane proteins

Eskelinen, E., Tanaka, Y., & Säftig, P. (2003) · Trends in Cell Biology · doi:10.1016/s0962-8924(03)00005-9 · Cited by 661 · see citing works

Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features

Berghe, T. V., Vanlangenakker, N., Parthoens, E., Deckers, W., Devos, M., Festjens, N., Guerin, C. J., Brunk, U. T., Declercq, W., & Vandenabeele, P. (2010) · Cell Death & Differentiation · doi:10.1038/cdd.2009.184 · Cited by 639 · see citing works

Cathepsin B Acts as a Dominant Execution Protease in Tumor Cell Apoptosis Induced by Tumor Necrosis Factor

Foghsgaard, L., Wissing, D., Mauch, D., Lademann, U. A., Bastholm, L., Boes, M. L., Elling, F., Leist, M., & Jäättelä, M. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.5.999 · Cited by 629 · see citing works

Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis

Halangk, W., Lerch, M. M., Brandt-Nedelev, B., Roth, W., Ruthenbürger, M., Reinheckel, T., Domschke, W., Lippert, H., Peters, C., & Deussing, J. M. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9411 · Cited by 564 · see citing works

Heat Shock Protein 70 Promotes Cell Survival by Inhibiting Lysosomal Membrane Permeabilization

Nylandsted, J., Gyrd-Hansen, M., Danielewicz, A., Fehrenbacher, N., Lademann, U., Høyer-Hansen, M., Weber, E., Multhoff, G., Rohde, M., & Jäättelä, M. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040531 · Cited by 545 · see citing works

Hsp70 stabilizes lysosomes and reverts Niemann–Pick disease-associated lysosomal pathology

Kirkegaard, T., Roth, A. G., Petersen, N. H. T., Mahalka, A. K., Olsen, O. D., Moilanen, I., Zylicz, A., Knudsen, J., Sandhoff, K., Arenz, C., et al. (2010) · Nature · doi:10.1038/nature08710 · Cited by 519 · see citing works

Lysosomal Membrane Permeabilization Induces Cell Death in a Mitochondrion-dependent Fashion

Boya, P., Andreau, K., Poncet, D., Zamzami, N., Perfettini, J.-L., Metivier, D., Ojcius, D. M., Jäättelä, M., & Kroemer, G. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021952 · Cited by 483 · see citing works

Selective Disruption of Lysosomes in HeLa Cells Triggers Apoptosis Mediated by Cleavage of Bid by Multiple Papain-like Lysosomal Cathepsins

Cirman, T., Bender, K. O., Droga-Mazovec, G., Türk, V., Reed, J. C., Myers, R., Salvesen, G. S., & Turk, B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m308347200 · Cited by 479 · see citing works

Adenovirus Protein VI Mediates Membrane Disruption following Capsid Disassembly

Wiethoff, C. M., Wodrich, H., Gerace, L., & Nemerow, G. R. (2005) · Journal of Virology · doi:10.1128/jvi.79.4.1992-2000.2005 · Cited by 466 · see citing works

Cathepsin D protease mediates programmed cell death induced by interferon‐gamma, Fas/APO‐1 and TNF‐alpha.

Deiss, L. P., Galinka, H., Berissi, H., Cohen, O., & Kimchi, A. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00760.x · Cited by 465 · see citing works

Regulation of apoptosis-associated lysosomal membrane permeabilization

Johansson, A., Appelqvist, H., Nilsson, C., Kågedal, K., Roberg, K. B., & Öllinger, K. M. (2010) · APOPTOSIS · doi:10.1007/s10495-009-0452-5 · Cited by 463 · see citing works

Lysosomes revisited

de Duve, C. (1983) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1983.tb07841.x · Cited by 446 · see citing works

Cathepsin D Triggers Bax Activation, Resulting in Selective Apoptosis-inducing Factor (AIF) Relocation in T Lymphocytes Entering the Early Commitment Phase to Apoptosis

Bidère, N., Lorenzo, H. K., Carmona, S., Laforge, M., Harper, F., Dumont, C., & Senik, A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301911200 · Cited by 435 · see citing works

Lysosomes and lysosomal cathepsins in cell death

Repnik, U., Stoka, V., Türk, V., & Turk, B. (2011) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2011.08.016 · Cited by 403 · see citing works

Cysteine Cathepsins Trigger Caspase-dependent Cell Death through Cleavage of Bid and Antiapoptotic Bcl-2 Homologues

Droga-Mazovec, G., Bojič, L., Petelin, A., Ivanova, S., Romih, R., Repnik, U., Salvesen, G. S., Stoka, V., Turk, V., & Turk, B. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802513200 · Cited by 399 · see citing works

Lysosomal involvement in cell death and cancer

Kirkegaard, T., & Jäättelä, M. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.09.008 · Cited by 395 · see citing works

Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2

Nylandsted, J., Rohde, M., Brand, K., Bastholm, L., Elling, F., & Jäättelä, M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.14.7871 · Cited by 393 · see citing works

Sphingosine-induced apoptosis is dependent on lysosomal proteases

Kågedal, K., Ming, Z. H. A. O., Svensson, I., & Brunk, U. T. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3590335 · Cited by 379 · see citing works

Cathepsin D targeted by acid sphingomyelinase‐derived ceramide

Heinrich, M., Wickel, M., Schneider‐Brachert, W., Sandberg, C., Gahr, J., Schwandner, R., Weber, T., Brunner, J., Krönke, M., & Schütze, S. (1999) · The EMBO Journal · doi:10.1093/emboj/18.19.5252 · Cited by 365 · see citing works

Characterization of the necrotic cleavage of poly(ADP-ribose) polymerase (PARP-1): implication of lysosomal proteases

Gobeil, S., Boucher, C., Nadeau, D., & Poirier, G. G. (2001) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400851 · Cited by 339 · see citing works

Diphtheria toxin fragment forms large pores in phospholipid bilayer membranes.

Kagan, B. L., Finkelstein, A. V., & Colombini, M. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.8.4950 · Cited by 337 · see citing works

Cathepsin D links TNF-induced acid sphingomyelinase to Bid-mediated caspase-9 and -3 activation

Heinrich, M., Neumeyer, J., Jakob, M., Hallas, C., Tchikov, V., Winoto‐Morbach, S., Wickel, M., Schneider‐Brachert, W., Trauzold, A., Hethke, A., et al. (2004) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401382 · Cited by 333 · see citing works

Stat3 controls lysosomal-mediated cell death in vivo

Kreuzaler, P. A., Staniszewska, A. D., Li, W., Omidvar, N., Kedjouar, B., Turkson, J., Poli, V., Flavell, R. A., Clarkson, R. W. E., & Watson, C. J. (2011) · Nature Cell Biology · doi:10.1038/ncb2171 · Cited by 312 · see citing works

Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans

Syntichaki, P., Xu, K., Driscoll, M., & Tavernarakis, N. (2002) · Nature · doi:10.1038/nature01108 · Cited by 305 · see citing works

Atractyloside‐induced release of cathepsin B, a protease with caspase‐processing activity

Vancompernolle, K., Herreweghe, F. V., PYNAERT, G. N., de Craen, M. V., Vos, K. J. D., Totty, N., Sterling, A., Fiers, W., Vandenabeele, P., & Grooten, J. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01275-7 · Cited by 304 · see citing works

Non‐specific effects of methyl ketone peptide inhibitors of caspases

Schotte, P., Declercq, W., Huffel, S. V., Vandenabeele, P., & Beyaert, R. (1999) · FEBS Letters · doi:10.1016/s0014-5793(98)01640-8 · Cited by 302 · see citing works

Lysosomes in iron metabolism, ageing and apoptosis

Kurz, T., Terman, A., Gustafsson, B., & Brunk, U. T. (2008) · Histochemistry and Cell Biology · doi:10.1007/s00418-008-0394-y · Cited by 302 · see citing works

Cancer-associated lysosomal changes: friends or foes?

Kallunki, T., Olsen, O. D., & Jäättelä, M. (2012) · Oncogene · doi:10.1038/onc.2012.292 · Cited by 301 · see citing works

TRPM2: a multifunctional ion channel for calcium signalling

Sumoza‐Toledo, A., & Penner, R. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2010.201855 · Cited by 290 · see citing works

Lysosomal enzymes promote mitochondrial oxidant production, cytochrome c release and apoptosis

Zhao, M., Antunes, F., Eaton, J. W., & Brunk, U. T. (2003) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2003.03765.x · Cited by 288 · see citing works

Lysosomes and oxidative stress in aging and apoptosis

Kurz, T., Terman, A., Gustafsson, B., & Brunk, U. T. (2008) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.01.009 · Cited by 287 · see citing works

Exogenous siRNA delivery using peptide transduction domains/cell penetrating peptides

Meade, B. R., & Dowdy, S. F. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.03.004 · Cited by 274 · see citing works

Delivery into cells: lessons learned from plant and bacterial toxins

Sandvig, K., & van Deurs, B. (2005) · Gene Therapy · doi:10.1038/sj.gt.3302525 · Cited by 273 · see citing works

The Cationic Cell-Penetrating Peptide CPP TAT Derived from the HIV-1 Protein TAT Is Rapidly Transported into Living Fibroblasts: Optical, Biophysical, and Metabolic Evidence

Ziegler, A., Nervi, P., Dürrenberger, M. B., & Seelig, J. (2004) · Biochemistry · doi:10.1021/bi0491604 · Cited by 266 · see citing works

Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation

Conus, S., Perozzo, R., Reinheckel, T., Peters, C., Scapozza, L., Yousefi, S., & Simon, H. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20072152 · Cited by 262 · see citing works

Inhibition of ischaemic hippocampal neuronal death in primates with cathepsin B inhibitor CA‐074: a novel strategy for neuroprotection based on ‘calpain–cathepsin hypothesis’

Yamashima, T., Kohda, Y., Tsuchiya, K., Ueno, T., Yamashita, J., Yoshioka, T., & Kominami, E. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00184.x · Cited by 254 · see citing works

Effective Tumor Cell Death by σ-2 Receptor Ligand Siramesine Involves Lysosomal Leakage and Oxidative Stress

Ostenfeld, M. S., Fehrenbacher, N., Høyer-Hansen, M. H., Thomsen, C., Farkas, T., & Jäättelä, M. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0269 · Cited by 250 · see citing works

Induction of cell death by the lysosomotropic detergent MSDH

Li, W., Yuan, X., Nordgren, G., Dalen, H., Dubowchik, G. M., Firestone, R. A., & Brunk, U. T. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01286-2 · Cited by 245 · see citing works

Sensitization to the Lysosomal Cell Death Pathway by Oncogene-Induced Down-regulation of Lysosome-Associated Membrane Proteins 1 and 2

Fehrenbacher, N., Bastholm, L., Kirkegaard‐Sørensen, T., Rafn, B., Bøttzauw, T., Nielsen, C. W., Weber, E., Shirasawa, S., Kallunki, T., & Jäättelä, M. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0463 · Cited by 242 · see citing works

Lysosomal destabilization in p53-induced apoptosis

Yuan, X., Li, W., Dalen, H., Lotem, J., Kama, R., Sachs, L., & Brunk, U. T. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.092135599 · Cited by 226 · see citing works

Potential role for Cathepsin D in p53-dependent tumor suppression and chemosensitivity

Wu, G. S., Säftig, P., Peters, C., & El‐Deiry, W. S. (1998) · Oncogene · doi:10.1038/sj.onc.1201755 · Cited by 226 · see citing works

Lysosomal pathways to cell death and their therapeutic applications

Česen, M. H., Pegan, K., Špes, A., & Turk, B. (2012) · Experimental Cell Research · doi:10.1016/j.yexcr.2012.03.005 · Cited by 223 · see citing works

Induction of lysosomal membrane permeabilization by compounds that activate p53-independent apoptosis

Erdal), D. H. K. (., Berndtsson, M., Castro, J., Brunk, U. T., Shoshan, M. C., & Linder, S. T. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408592102 · Cited by 218 · see citing works

Vincristine Induces Dramatic Lysosomal Changes and Sensitizes Cancer Cells to Lysosome-Destabilizing Siramesine

Groth‐Pedersen, L., Ostenfeld, M. S., Høyer-Hansen, M. H., Nylandsted, J., & Jäättelä, M. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3520 · Cited by 215 · see citing works

Involvement of caspase-dependent activation of cytosolic phospholipase A 2 in tumor necrosis factor-induced apoptosis

Wissing, D., Mouritzen, H., Egeblad, M., Poirier, G. G., & Jäättelä, M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5073 · Cited by 207 · see citing works

Cathepsin B Mediates Caspase-Independent Cell Death Induced by Microtubule Stabilizing Agents in Non-Small Cell Lung Cancer Cells

Bröker, L. E., Huisman, C., Span, S. W., Rodríguez, J. A., Kruyt, F. A. E., & Giaccone, G. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3060 · Cited by 206 · see citing works

Inhibition of ischaemic hippocampal neuronal death in primates with cathepsin B inhibitor CA‐074: a novel strategy for neuroprotection based on ‘calpain–cathepsin hypothesis’

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Cathepsin B Knockout Mice Are Resistant to Tumor Necrosis Factor-α-Mediated Hepatocyte Apoptosis and Liver Injury

Guicciardi, M. E., Miyoshi, H., Bronk, S. F., & Gores, G. J. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63056-8 · Cited by 204 · see citing works

Lysosomal membrane permeabilization and cathepsin release is a Bax/Bak-dependent, amplifying event of apoptosis in fibroblasts and monocytes

Oberle, C., Huai, J., Reinheckel, T., Tacke, M., Rassner, M., Ekert, P. G., Buellesbach, J., & Borner, C. (2010) · Cell Death & Differentiation · doi:10.1038/cdd.2009.214 · Cited by 193 · see citing works

BH3-only proteins in apoptosis at a glance

Happo, L., Strasser, A., & Cory, S. (2012) · Journal of Cell Science · doi:10.1242/jcs.090514 · Cited by 193 · see citing works

Microinjection of Cathepsin D Induces Caspase-Dependent Apoptosis in Fibroblasts

Roberg, K. B., Kågedal, K., & Öllinger, K. M. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64160-0 · Cited by 193 · see citing works

Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis

Canbay, A. E., Guicciardi, M. E., Higuchi, H., Feldstein, A. E., Bronk, S. F., Rydzewski, R. M., Taniai, M., & Gores, G. J. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17740 · Cited by 193 · see citing works

Combating apoptosis and multidrug resistant cancers by targeting lysosomes

Groth‐Pedersen, L., & Jäättelä, M. (2010) · Cancer Letters · doi:10.1016/j.canlet.2010.05.021 · Cited by 192 · see citing works

Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis

Canbay, A. E., Guicciardi, M. E., Higuchi, H., Feldstein, A. E., Bronk, S. F., Rydzewski, R. M., Taniai, M., & Gores, G. J. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317740 · Cited by 188 · see citing works

Critical role for cathepsin B in mediating caspase-1-dependent interleukin-18 maturation and caspase-1-independent necrosis triggered by the microbial toxin nigericin

Hentze, H., Lin, X. Y., Choi, M. S. K., & Porter, A. G. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401264 · Cited by 187 · see citing works

The role of lysosomal rupture in neuronal death

Yamashima, T., & Oikawa, S. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.09.003 · Cited by 183 · see citing works

Tumor necrosis factor-α-associated lysosomal permeabilization is cathepsin B dependent

Werneburg, N. W., Guicciardi, M. E., Bronk, S. F., & Gores, G. J. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00151.2002 · Cited by 179 · see citing works

An Intracellular Serpin Regulates Necrosis by Inhibiting the Induction and Sequelae of Lysosomal Injury

Luke, C. J., Pak, S. C., Askew, Y. S., Naviglia, T. L., Askew, D. J., Nobar, S. M., Vetica, A. C., Long, O. S., Watkins, S. C., Stolz, D. B., et al. (2007) · Cell · doi:10.1016/j.cell.2007.07.013 · Cited by 166 · see citing works

Killing a cancer: what are the alternatives?

Kreuzaler, P. A., & Watson, C. J. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3264 · Cited by 162 · see citing works

Hypochlorous acid induces apoptosis of cultured cortical neurons through activation of calpains and rupture of lysosomes

Yap, Y. W., Whiteman, M., Bay, B., Li, Y., Sheu, F., Qi, R. Z., Tan, C. H., & Cheung, N. S. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03996.x · Cited by 161 · see citing works

Anti-cancer agent siramesine is a lysosomotropic detergent that induces cytoprotective autophagosome accumulation

Ostenfeld, M. S., Høyer-Hansen, M. H., Bastholm, L., Fehrenbacher, N., Olsen, O. D., Groth‐Pedersen, L., Puustinen, P., Kirkegaard‐Sørensen, T., Nylandsted, J., Farkas, T., et al. (2008) · Autophagy · doi:10.4161/auto.5774 · Cited by 160 · see citing works

Cytosolic Activation of Cathepsins Mediates Parvovirus H-1-Induced Killing of Cisplatin and TRAIL-Resistant Glioma Cells

Piazza, M., Mader, C., Geletneky, K., y Calle, M. H., Weber, E., Schlehofer, J. R., Deleu, L., & Rommelaere, J. (2007) · Journal of Virology · doi:10.1128/jvi.02601-06 · Cited by 155 · see citing works

Transient Brain Ischaemia Provokes Ca 2+ , PIP 2 and Calpain Responses Prior to Delayed Neuronal Death in Monkeys

Yamashima, T., Saido, T. C., Takita, M., Miyazawa, A., Yamano, J., Miyakawa, A., Nishijyo, H., Yamashita, J., Kawashima, S., Ono, T., et al. (1996) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1996.tb01337.x · Cited by 146 · see citing works

Sensitization to the Lysosomal Cell Death Pathway upon Immortalization and Transformation

Fehrenbacher, N., Gyrd‐Hansen, M., Poulsen, B., Felbor, U., Kallunki, T., Boes, M. L., Weber, E., Leist, M., & Jäättelä, M. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1427 · Cited by 144 · see citing works

Virus-mediated release of endosomal content in vitro: different behavior of adenovirus and rhinovirus serotype 2.

Prchla, E., Plank, C., Wagner, E., Blaas, D., & Fuchs, R. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.131.1.111 · Cited by 140 · see citing works

Activation of pro-caspase-7 by serine proteases includes a non-canonical specificity

Zhou, Q., & Salvesen, G. S. (1997) · Biochemical Journal · doi:10.1042/bj3240361 · Cited by 131 · see citing works

Lysosomotropic agents. 1. Synthesis and cytotoxic action of lysosomotropic detergents

Firestone, R. A., Pisano, J. M., & Bonney, R. J. (1979) · Journal of Medicinal Chemistry · doi:10.1021/jm00195a026 · Cited by 131 · see citing works

BAMLET Activates a Lysosomal Cell Death Program in Cancer Cells

Rammer, P., Groth‐Pedersen, L., Kirkegaard, T., Daugaard, M., Rytter, A., Szyniarowski, P., Høyer-Hansen, M. H., Povlsen, L. K., Nylandsted, J., Larsen, J. E., et al. (2010) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-09-0559 · Cited by 127 · see citing works

Tumor Necrosis Factor-related Apoptosis-inducing Ligand Activates a Lysosomal Pathway of Apoptosis That Is Regulated by Bcl-2 Proteins

Werneburg, N. W., Guicciardi, M. E., Bronk, S. F., Kaufmann, S. H., & Gores, G. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705671200 · Cited by 126 · see citing works

Lysosomal membrane permeabilization during apoptosis ‐ involvement of Bax?

Kågedal, K., Johansson, A., Johansson, U., Heimlich, G., Roberg, K. B., Wang, N. S., Jürgensmeier, J. M., & Öllinger, K. M. (2005) · International Journal of Experimental Pathology · doi:10.1111/j.0959-9673.2005.00442.x · Cited by 124 · see citing works

Mechanism of apoptosis induced by a lysosomotropic agent, L-Leucyl-L-Leucine methyl ester

Uchimoto, T., Nohara, H., Kamehara, R., Iwamura, M., Watanabe, N., & Kobayashi, Y. (1999) · APOPTOSIS · doi:10.1023/a:1009695221038 · Cited by 122 · see citing works

Cancer cell injury by cytotoxins from cobra venom is mediated through lysosomal damage

Feofanov, A. V., Sharonov, G. V., Astapova, M. V., Rodionov, D. I., Utkin, Y. N., & Arseniev, A. S. (2005) · Biochemical Journal · doi:10.1042/bj20041892 · Cited by 119 · see citing works

NF‐κB protects from the lysosomal pathway of cell death

Liu, N., Raja, S. M., Zazzeroni, F., Metkar, S. S., Shah, R., Zhang, M., Wang, Y., Brömme, D., Russin, W. A., Lee, J. C., et al. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg510 · Cited by 116 · see citing works

Reduced tumour cell proliferation and delayed development of high-grade mammary carcinomas in cathepsin B-deficient mice

Vasiljeva, O. S., Korovin, M. S., Gajda, M. R., Brodoefel, H., Bojić, L., Krüger, A., Schurigt, U., Sevenich, L., Turk, B., Peters, C., et al. (2008) · Oncogene · doi:10.1038/onc.2008.59 · Cited by 115 · see citing works

TNF-α-mediated lysosomal permeabilization is FAN and caspase 8/Bid dependent

Werneburg, N., Guicciardi, M. E., Yin, X., & Gores, G. J. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00019.2004 · Cited by 114 · see citing works

Uncoating of human rhinoviruses

Fuchs, R., & Blaas, D. (2010) · Reviews in Medical Virology · doi:10.1002/rmv.654 · Cited by 113 · see citing works

Apoptosome-Independent Activation of the Lysosomal Cell Death Pathway by Caspase-9

Gyrd‐Hansen, M., Farkas, T., Fehrenbacher, N., Bastholm, L., Høyer-Hansen, M. H., Elling, F., Wallach, D., Flavell, R. A., Kroemer, G., Nylandsted, J., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00716-06 · Cited by 111 · see citing works

Cathepsin B but not cathepsins L or S contributes to the pathogenesis of Unverricht‐Lundborg progressive myoclonus epilepsy (EPM1)

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