The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Autophagy is required for extension of yeast chronological life span by rapamycin
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“While autophagy thus seems to be very important from this description alone, studies in yeast, worms, and flies have shown that inactivation of autophagy shortens lifespan, while promotion of autophagy extends lifespan 65–67.”
From Targeting the biology of aging with mTOR inhibitors (2023) · cites this paper as [65]
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“Importantly, autophagy has also been shown to be required for the extension of lifespan by reduced mTOR signaling in both yeast and worms 65,68.”
From Targeting the biology of aging with mTOR inhibitors (2023) · cites this paper as [65]
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Citations
Cites
Molecular dissection of autophagy: two ubiquitin-like systems
Ohsumi, Y. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35056522 · Cited by 1,240
Influence of TOR kinase on lifespan in C. elegans
Vellai, T., Takacs-Vellai, K., Zhang, Y., Kovacs, A. L., Orosz, L., & Müller, F. (2003) · Nature · doi:10.1038/426620a · Cited by 1,057
Research works printed but not linked: 15
- [2]Kapahi P Zid BM Harper T Koslover D Sapin V Benzer S Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway Curr Biol 2004 14 885 90 15186745 PMC2754830
- [3]Kaeberlein M Powers RW III Steffen KK Westman EA Hu D Dang N Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients Science 2005 310 1193 6 16293764
- [4]Bonawitz ND Chatenay-Lapointe M Pan Y Shadel GS Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression Cell Metab 2007 5 265 77 17403371 PMC3460550
- [5]Powers RW III Kaeberlein M Caldwell SD Kennedy BK Fields S Extension of chronological life span in yeast by decreased TOR pathway signaling Genes Dev 2006 20 174 84 16418483 PMC1356109
- [6]Steffen KK MacKay VL Kerr EO Tsuchiya M Hu D Fox LA Yeast life span extension by depletion of 60S ribosomal subunits is mediated by Gcn4 Cell 2008 133 292 302 18423200 PMC2749658
- [7]Wullschleger S Loewith R Hall MN TOR signaling in growth and metabolism Cell 2006 124 471 84 16469695
- [8]Kamada Y Sekito T Ohsumi Y Autophagy in yeast: a TOR-mediated response to nutrient starvation Curr Top Microbiol Immunol 2004 279 73 84 14560952
- [9]De Virgilio C Loewith R Cell growth control: little eukaryotes make big contributions Oncogene 2006 25 6392 415 17041625
- [10]Stephan JS Herman PK The regulation of autophagy in eukaryotic cells: do all roads pass through Atg1? Autophagy 2006 2 146 8 16874100
- [12]He C Song H Yorimitsu T Monastyrska I Yen WL Legakis JE Klionsky DJ Recruitment of Atg9 to the preautophagosomal structure by Atg11 is essential for selective autophagy in budding yeast J Cell Biol 2006 175 925 35 17178909 PMC2064702
- [13]Alvers AL Fishwick LK Wood MS Hu D Chung HS Dunn WA Jr Aris JP Autophagy and amino acid homeostasis are required for chronological longevity in Saccharomyces cerevisiae Aging Cell 2009 In Press PMC2802268 19302372
- [14]Klionsky DJ Cuervo AM Seglen PO Methods for monitoring autophagy from yeast to human Autophagy 2007 3 181 206 17224625
- [15]Sherman F Getting started with yeast Methods Enzymol 2002 350 3 41 12073320
- [16]Winzeler EA Shoemaker DD Astromoff A Liang H Anderson K Andre B Functional characterization of the S.cerevisiae genome by gene deletion and parallel analysis Science 1999 285 901 6 10436161
- [17]Kim J Huang WP Klionsky DJ Membrane recruitment of Aut7p in the autophagy and cytoplasm to vacuole targeting pathways requires Aut1p, Aut2p, and the autophagy conjugation complex J Cell Biol 2001 152 51 64 11149920 PMC2193654
Cited by
Sorted by citations
mTOR is a key modulator of ageing and age-related disease
Johnson, S. C., Rabinovitch, P. S., & Kaeberlein, M. (2013) · Nature · doi:10.1038/nature11861 · Cited by 1,676
Autophagy in healthy aging and disease
Aman, Y., Schmauck-Medina, T., Hansen, M., Morimoto, R. I., Simon, A. K., Bjedov, I., Palikaras, K., Simonsen, A., Johansen, T., Tavernarakis, N., et al. (2021) · Nature Aging · doi:10.1038/s43587-021-00098-4 · Cited by 1,313
Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila Melanogaster
Bjedov, I., Toivonen, J. M., Kerr, F., Slack, C., Jacobson, J., Foley, A., & Partridge, L. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2009.11.010 · Cited by 1,057
Autophagy as a promoter of longevity: insights from model organisms
Hansen, M., Rubinsztein, D. C., & Walker, D. W. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0033-y · Cited by 754
Rapalogs and mTOR inhibitors as anti-aging therapeutics
Lamming, D. W., Ye, L., Sabatini, D. M., & Baur, J. A. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64099 · Cited by 531
Metadata
- Authors
- Alvers, A. L., Wood, M. S., Hu, D., Kaywell, A. C., Dunn, Jr., & Aris, J. P.
- Venue
- Autophagy
- Publisher
- Informa UK Limited
- Published
- 2009-08-16
- Volume
- 5
- Issue
- 6
- Pages
- 847-849
- ISSN
- 1554-8627
- 1554-8635
- PMC
- PMC3586265
- Cited by
- 189
- References
- 2
- Language
- en
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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