Autophagy as a promoter of longevity: insights from model organisms

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

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The Hallmarks of Aging

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mTOR Signaling in Growth, Metabolism, and Disease

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Autophagy in the Pathogenesis of Disease

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

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Autophagy and Viruses: Adversaries or Allies?

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Autophagy regulates lipid metabolism

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Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

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TFEB Links Autophagy to Lysosomal Biogenesis

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Mechanisms of mitophagy

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A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

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Mechanism and medical implications of mammalian autophagy

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The genetics of ageing

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Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

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The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

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The machinery of macroautophagy

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The pathways of mitophagy for quality control and clearance of mitochondria

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A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

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Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

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Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

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Selective autophagy mediated by autophagic adapter proteins

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Induction of autophagy by spermidine promotes longevity

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The mitochondrial basis of aging

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α-Synuclein Is Degraded by Both Autophagy and the Proteasome

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The coming of age of chaperone-mediated autophagy

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Autophagy maintains stemness by preventing senescence

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Neural mechanisms of ageing and cognitive decline

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Autophagy Genes Are Essential for Dauer Development and Life-Span Extension in <i>C. elegans</i>

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Mitochondria and the Autophagy–Inflammation–Cell Death Axis in Organismal Aging

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Mitochondrial pathology and apoptotic muscle degeneration in <i>Drosophila parkin</i> mutants

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Spermidine in health and disease

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Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities

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Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

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Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy

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Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila Melanogaster

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Autophagy maintains the metabolism and function of young and old stem cells

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α-Synuclein impairs macroautophagy: implications for Parkinson’s disease

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Longer lifespan, altered metabolism, and stress resistance in <i>Drosophila</i> from ablation of cells making insulin-like ligands

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Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia

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Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

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A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans

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Identification of a candidate therapeutic autophagy-inducing peptide

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Overexpression of Atg5 in mice activates autophagy and extends lifespan

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Ubiquitin-Dependent And Independent Signals In Selective Autophagy

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Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

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Measuring In Vivo Mitophagy

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Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer’s disease

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Age-related decline in chaperone-mediated autophagy

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Rapamycin alleviates toxicity of different aggregate-prone proteins

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FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging

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Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury

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Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice

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The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR

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Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila

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Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy

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Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand

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Hypothalamic stem cells control ageing speed partly through exosomal miRNAs

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Recurrent mutation of the gene encoding sequestosome 1 (SQSTM1/p62) in Paget disease of bone.

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Autophagy is required for glucose homeostasis and lung tumor maintenance

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An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast

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The mechanistic target of rapamycin: the grand conducTOR of metabolism and aging

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Autophagy is defective in collagen VI muscular dystrophies, and its reactivation rescues myofiber degeneration

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The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans

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Distinct Shifts in Microbiota Composition during Drosophila Aging Impair Intestinal Function and Drive Mortality

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Lipophagy: Connecting Autophagy and Lipid Metabolism

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Stress-Response Hormesis and Aging: “That which Does Not Kill Us Makes Us Stronger”

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De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood

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Untitled work

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Longevity pathways converge on autophagy genes to regulate life span inCaenorhabditis elegans

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Autophagy Impairment in Muscle Induces Neuromuscular Junction Degeneration and Precocious Aging

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Fat Metabolism Links Germline Stem Cells and Longevity in C. elegans

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Skeletal muscle autophagy and apoptosis during aging: Effects of calorie restriction and life-long exercise

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Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner

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Exome Sequencing Reveals De Novo WDR45 Mutations Causing a Phenotypically Distinct, X-Linked Dominant Form of NBIA

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Polyglutamine tracts regulate beclin 1-dependent autophagy

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Moderate dietary protein restriction alters the composition of gut microbiota and improves ileal barrier function in adult pig model

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Autophagy and Lipid Metabolism Coordinately Modulate Life Span in Germline-less C. elegans

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Autophagy is Required for Dietary Restriction-Mediated Life Span Extension in<i>C. elegans</i>

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VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy

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Transcriptional and epigenetic regulation of autophagy in aging

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Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan

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MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability

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Autophagy and Human Disease

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AMPK Modulates Tissue and Organismal Aging in a Non-Cell-Autonomous Manner

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Reproduction, Fat Metabolism, and Life Span: What Is the Connection?

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Induction of autophagy supports the bioenergetic demands of quiescent muscle stem cell activation

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Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster

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<i>SQSTM1</i> mutations in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

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Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans

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