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Calcium orthophosphates: Occurrence, properties, biomineralization, pathological calcification and biomimetic applications

Open access
Dorozhkin, Sergey V.·2011·Biomatter

Abstract

The present overview is intended to point the readers' attention to the important subject of calcium orthophosphates. This type of materials is of special significance for human beings, because they represent the inorganic part of major normal (bones, teeth and antlers) and pathological (i.e., those appearing due to various diseases) calcified tissues of mammals. For example, atherosclerosis results in blood vessel blockage caused by a solid composite of cholesterol with calcium orthophosphates, while dental caries and osteoporosis mean a partial decalcification of teeth and bones, respectively, that results in replacement of a less soluble and harder biological apatite by more soluble and softer calcium hydrogenphosphates. Therefore, the processes of both normal and pathological calcifications are just an in vivo crystallization of calcium orthophosphates. Similarly, dental caries and osteoporosis might be considered an in vivo dissolution of calcium orthophosphates. Thus, calcium orthophosphates hold a great significance for humankind, and in this paper, an overview on the current knowledge on this subject is provided.

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Metadata

Authors
Dorozhkin, S. V.
Venue
Biomatter
Published
2011-10
Volume
1
Issue
2
Pages
121-164
ISSN
  • 2159-2527 (ISSN-L)
  • 2159-2535
OpenAlex
W2073675404
Cited by
370
References
16
FWCI
5.65
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Calcium orthophosphates: Occurrence, properties, biomineralization, pathological calcification and biomimetic applications. https://app.cochat.ai/papers/10.4161/biom.18790
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Dorozhkin, S. V. (2011). Calcium orthophosphates: Occurrence, properties, biomineralization, pathological calcification and biomimetic applications. Biomatter. https://doi.org/10.4161/biom.18790

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.