Cited by 482Alzheimer's disease research and treatmentsAdvanced Glycation End Products researchDementia and Cognitive Impairment Research

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Oxidative stress in Alzheimer disease

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Gella, Alejandro, Durany, Nuria·2009·Cell Adhesion & Migration

DOI 10.4161/cam.3.1.7402PMC PMC2675154

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Abstract

Alzheimer disease (AD) is a progressive dementia affecting a large proportion of the aging population. The histopathological changes in AD include neuronal cell death, formation of amyloid plaques and neurofibrillary tangles. There is also evidence that brain tissue in patients with AD is exposed to oxidative stress (e.g., protein oxidation, lipid oxidation, DNA oxidation and glycoxidation) during the course of the disease. Advanced glycation endproducts (AGEs) are present in amyloid plaques in AD, and its extracellular accumulation may be caused by an accelerated oxidation of glycated proteins. AGEs participate in neuronal death causing direct (chemical) and indirect (cellular) free radical production and consequently increase oxidative stress. The development of drugs for the treatment of AD that breaks the vicious cycles of oxidative stress and neurodegeneration offer new opportunities. These approaches include AGE-inhibitors, antioxidants and anti-inflammatory substances, which prevent free radical production.

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Authors: Gella, A., & Durany, N.
Affiliations: Universitat Internacional de Catalunya (ES)
Corresponding author: Gella, Alejandro
ORCID: Gella, Alejandro
Venue: Cell Adhesion & Migration
Publisher: Informa UK Limited
Published: 2009-01
Volume: 3
Issue: 1
Pages: 88-93
ISSN: 1933-6918 (ISSN-L)
1933-6926
DOI: 10.4161/cam.3.1.7402
PMC: PMC2675154
OpenAlex: W2000446523
Cited by: 459
References: 97
Citations by year: 2026: 23 · 2025: 45 · 2024: 42 · 2023: 56 · 2022: 41 · 2021: 36 · 2020: 20 · 2019: 34 · 2018: 25 · 2017: 27 · 2016: 20 · 2015: 11 · 2014: 20 · 2013: 18 · 2012: 14
FWCI: 1.39
Type: journal article
Language: en
Open access: gold
doi.org
Locations: Cell Adhesion & Migration (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: Alzheimer's disease, oxidative stress, advanced glycation end products, amyloid plaques, neurofibrillary tangles, protein oxidation, lipid peroxidation, DNA oxidation, glycoxidation, free radicals, neuronal cell death, neurodegeneration, antioxidants, anti-inflammatory agents, AGE inhibitors
MeSH terms: Alzheimer Disease, Animals, Glucose, Humans, Oxidation-Reduction, Glycation End Products, Advanced, Oxidative Stress, Feedback, Physiological

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