Oxidative stress in Alzheimer disease

Neurodegenerative diseases and oxidative stress

Barnham, K. J., Masters, C. L., & Bush, A. I. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1330 · Cited by 3,683

Protein Oxidation in Aging, Disease, and Oxidative Stress

Berlett, B. S., & Stadtman, E. R. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.33.20313 · Cited by 3,379

[37] Carbonyl assays for determination of oxidatively modified proteins

Levine, R. L., Williams, J. A., Stadtman, E. R., & Shacter, E. B. (1994) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(94)33040-9 · Cited by 2,707

Diabetes mellitus and the risk of dementia: The Rotterdam Study

Ott, A., Stolk, R. P., van Harskamp, F., Pols, H. A. P., Hofman, A., & Breteler, M. M. B. (1999) · Neurology · doi:10.1212/wnl.53.9.1937 · Cited by 2,175

RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease

Yan, S. D., Chen, X., Fu, J., Chen, M., Zhu, H., Roher, A., Slattery, T., Zhao, L., Nagashima, M., Morser, J., et al. (1996) · Nature · doi:10.1038/382685a0 · Cited by 2,012

Oxidative Damage Is the Earliest Event in Alzheimer Disease

Nunomura, A., Perry, G., Aliev, G., Hirai, K., Takeda, A., Balraj, E. K., Jones, P. K., Ghanbari, H., Wataya, T., Shimohama, S., et al. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.8.759 · Cited by 1,885

The oxidative environment and protein damage

Davies, M. J. (2005) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2004.08.007 · Cited by 1,392

The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses

Schmidt, A. M., Yan, S. D., Yan, S. F., & Stern, D. M. (2001) · Journal of Clinical Investigation · doi:10.1172/jci14002 · Cited by 1,256

Oxidative stress and Alzheimer disease

Christen, Y. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.2.621s · Cited by 1,176

The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses

Schmidt, A. M., Yan, S. D., Yan, S. F., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200114002 · Cited by 1,039

Oxidative stress and inflammation in the pathogenesis of neurological disorders: Mechanisms and implications

Dash, U. C., Bhol, N. K., Swain, S. K., Samal, R. R., Nayak, P. K., Raina, V., Panda, S. K., Kerry, R. G., Duttaroy, A. K., & Jena, A. B. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.10.004 · Cited by 806

Brain metabolic dysfunction at the core of Alzheimer's disease

de la Monte, S. M., & Tong, M. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.12.012 · Cited by 472

Neuroprotective and Antioxidant Effect of Ginkgo biloba Extract Against AD and Other Neurological Disorders

Singh, S. K., Srivastav, S., Castellani, R. J., Plascencia‐Villa, G., & Perry, G. L. (2019) · Neurotherapeutics · doi:10.1007/s13311-019-00767-8 · Cited by 428

Amyloid Beta in Aging and Alzheimer’s Disease

Sehar, U., Rawat, P., Reddy, A. P., Kopel, J. J., & Reddy, P. H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232112924 · Cited by 409

Heavy Metals Exposure and Alzheimer’s Disease and Related Dementias

Bakulski, K. M., Seo, Y. A., Hickman, R. C., Brandt, D. J., Vadari, H. S., Hu, H., & Park, S. K. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200282 · Cited by 361

PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease

Oksanen, M., Petersen, A. J., Naumenko, N., Puttonen, K., Lehtonen, Š., Gubert Olivé, M., Shakirzyanova, A., Leskelä, S., Sarajärvi, T., Viitanen, M., et al. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.10.016 · Cited by 332

Discovery, Biological Evaluation, and Crystal Structure of a Novel Nanomolar Selective Butyrylcholinesterase Inhibitor

Brus, B., Košak, U., Turk, S., Pišlar, A. H., Coquelle, N., Kos, J., Stojan, J., Colletier, J., & Gobec, S. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm501195e · Cited by 287

Oxidative stress and β-amyloid protein in Alzheimer’s disease

Cai, Z., Zhao, B., & Ratka, A. (2011) · NeuroMolecular Medicine · doi:10.1007/s12017-011-8155-9 · Cited by 279

Oxidative stress in alzheimer’s disease: A review on emergent natural polyphenolic therapeutics

Cassidy, L., Fernandez, F., Johnson, J. B., Naiker, M., Owoola, A. G., & Broszczak, D. A. (2019) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2019.102294 · Cited by 288

Use of Curcumin, a Natural Polyphenol for Targeting Molecular Pathways in Treating Age-Related Neurodegenerative Diseases

Maiti, P., & Dunbar, G. L. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061637 · Cited by 243

The PI3K/Akt signaling axis in Alzheimer’s disease: a valuable target to stimulate or suppress?

Razani, E., Pourbagheri‐Sigaroodi, A., Safaroghli‐Azar, A., Zoghi, A., Bavarsad, M. S., & Bashash, D. (2021) · Cell Stress and Chaperones · doi:10.1007/s12192-021-01231-3 · Cited by 232

Amyloid-beta peptide decreases glutamate uptake in cultured astrocytes: Involvement of oxidative stress and mitogen-activated protein kinase cascades

Matos, M., Augusto, E., Oliveira, C. R., & Agostinho, P. M. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.08.022 · Cited by 239

Role of mitochondrial dysfunction, oxidative stress and autophagy in progression of Alzheimer's disease

Bhatia, V., & Sharma, S. (2020) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2020.117253 · Cited by 228

Tau Protein Interaction Partners and Their Roles in Alzheimer’s Disease and Other Tauopathies

Sinsky, J., Pichlerova, K., & Hanes, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179207 · Cited by 220

Synthesis, Biological Evaluation, and Molecular Modeling of Donepezil and N-[(5-(Benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine Hybrids as New Multipotent Cholinesterase/Monoamine Oxidase Inhibitors for the Treatment of Alzheimer’s Disease

Bolea, I., Juárez‐Jiménez, J., Rı́os, C. D. L., Chioua, M., Pouplana, R., Luque, F. J., Unzeta, M., Marco, J. L., & Samadi, A. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm200853t · Cited by 220

Multifunctional compounds: Smart molecules for multifactorial diseases

Bansal, Y., & Silakari, O. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2014.01.060 · Cited by 215

Elevated Oxidative Stress and Decreased Antioxidant Function in the Human Hippocampus and Frontal Cortex with Increasing Age: Implications for Neurodegeneration in Alzheimer’s Disease

Venkateshappa, C., Harish, G., Mahadevan, A., Srinivas Bharath, M. M., & Shankar, S. K. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0755-8 · Cited by 232

Immunohistochemical analysis of human brain suggests pathological synergism of Alzheimer's disease and diabetes mellitus

Valente, T., Gella, A., Fernàndez‐Busquets, X., Unzeta, M., & Durany, N. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.09.008 · Cited by 210

Oxidative Stress Occurs Prior to Amyloid Aβ Plaque Formation and Tau Phosphorylation in Alzheimer’s Disease: Role of Glutathione and Metal Ions

Roy, R. G., Mandal, P. K., & Maroon, J. C. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00486 · Cited by 194

Ginkgo biloba Extract in Alzheimer’s Disease: From Action Mechanisms to Medical Practice

Shi, C., Liu, J., Wu, F., & Yew, D. T. W. (2010) · International Journal of Molecular Sciences · doi:10.3390/ijms11010107 · Cited by 192

Acetylene Group, Friend or Foe in Medicinal Chemistry

Talele, T. T. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b01617 · Cited by 184

Neuroprotective effect of hesperetin and nano-hesperetin on recognition memory impairment and the elevated oxygen stress in rat model of Alzheimer’s disease

kheradmand, E., Moghaddam, A. H., & Zare, M. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.11.047 · Cited by 175

The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity

Košak, U., Brus, B., Knez, D., Žakelj, S., Trontelj, J., Pišlar, A. H., Šink, R., Jukič, M., Živin, M., Podkowa, A., et al. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b01086 · Cited by 166

Novel tacrine-related drugs as potential candidates for the treatment of Alzheimer’s disease

Romero, A., Cacabelos, R., Oset‐Gasque, M. J., Samadi, A., & Marco, J. L. (2013) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2013.02.017 · Cited by 157

Propargylamine-derived multitarget-directed ligands: fighting Alzheimer’s disease with monoamine oxidase inhibitors

Bolea, I., Gella, A., & Unzeta, M. (2012) · Journal of Neural Transmission · doi:10.1007/s00702-012-0948-y · Cited by 158

Nanoparticle and other metal chelation therapeutics in Alzheimer disease

Liu, G., Garrett, M. R., Men, P., Zhu, X., Perry, G. L., & Smith, M. A. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2005.06.006 · Cited by 160

Nanoparticle formulations in the diagnosis and therapy of Alzheimer's disease

Gupta, J., Fatima, M. T., Islam, Z., Khan, R. H., Uversky, V. N., & Salahuddin, P. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.02.156 · Cited by 163

Triggers and Effectors of Oxidative Stress at Blood-Brain Barrier Level: Relevance for Brain Ageing and Neurodegeneration

Enciu, A., Gherghiceanu, M., & Popescu, B. O. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/297512 · Cited by 157

Glutathione Participation in the Prevention of Cardiovascular Diseases

Matuz‐Mares, D., Riveros‐Rosas, H., Vilchis‐Landeros, M. M., & Vázquez‐Meza, H. (2021) · Antioxidants · doi:10.3390/antiox10081220 · Cited by 152

Beneficial Role of Carica papaya Extracts and Phytochemicals on Oxidative Stress and Related Diseases: A Mini Review

Kong, Y. R., Jong, Y. X., Balakrishnan, M., Bok, Z. K., Weng, J. K. K., Tay, K. C., Goh, B. H., Ong, Y. S., Chan, K., Lee, L., et al. (2021) · Biology · doi:10.3390/biology10040287 · Cited by 177

Oxidative Stress and Redox Imbalance: Common Mechanisms in Cancer Stem Cells and Neurodegenerative Diseases

Selvaraj, N. R., Nandan, D., Nair, B. J. B., Nair, V. A., Venugopal, P., & Aradhya, R. (2025) · Cells · doi:10.3390/cells14070511 · Cited by 163

Antioxidant properties of dimethyl sulfoxide and its viability as a solvent in the evaluation of neuroprotective antioxidants

Sanmartín‐Suárez, C., Soto‐Otero, R., Sánchez‐Sellero, I., & Méndez‐Álvarez, E. (2010) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/j.vascn.2010.10.004 · Cited by 146

Lipidomic analysis of brain tissues and plasma in a mouse model expressing mutated human amyloid precursor protein/tau for Alzheimer’s disease

Tajima, Y., Ishikawa, M., Maekawa, K., Murayama, M., Senoo, Y., Nishimaki-Mogami, T., Nakanishi, H., Ikeda, K., Arita, M., Taguchi, R., et al. (2013) · Lipids in Health and Disease · doi:10.1186/1476-511x-12-68 · Cited by 139

Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil–indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease

Bautista‐Aguilera, Ó. M., Esteban, G., Bolea, I., Nikolic, K. M., Agbaba, D., Moraleda, I., Iriepa, I., Samadi, A., Soriano, E., Unzeta, M., et al. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2013.12.028 · Cited by 144

Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease

Wang, L., Esteban, G., Ojima, M., Bautista‐Aguilera, Ó. M., Inokuchi, T., Moraleda, I., Iriepa, I., Samadi, A., Youdim, M. B. H., Romero, A., et al. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2014.04.078 · Cited by 143

Blood-Based Biomarkers for Alzheimer’s Disease Diagnosis and Progression: An Overview

Varesi, A., Carrara, A., Pires, V. G., Floris, V., Pierella, E., Savioli, G., Prasad, S., Esposito, C., Ricevuti, G., Chirumbolo, S., et al. (2022) · Cells · doi:10.3390/cells11081367 · Cited by 150

Linking Oxidative Stress and Proteinopathy in Alzheimer’s Disease

Sharma, C., & Kim, S. R. (2021) · Antioxidants · doi:10.3390/antiox10081231 · Cited by 145

Oxidative Stress in Alzheimer's Disease and Mild Cognitive Impairment with High Sensitivity and Specificity

López, N., Tormo, C., Blas, I. D., Llinares, I., & Alom, J. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-121528 · Cited by 135

Neuroprotective effect of blackberry (Rubus sp.) polyphenols is potentiated after simulated gastrointestinal digestion

Tavares, L., Figueira, I., Macedo, D., McDougall, G. J., Leitão, M. C., Vieira, H. L. A., Stewart, D., Alves, P. M., Ferreira, R. B., & dos Santos, C. N. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.10.025 · Cited by 132

Potential for therapeutic use of hydrogen sulfide in oxidative stress-induced neurodegenerative diseases

Tabassum, R., & Jeong, N. Y. (2019) · International Journal of Medical Sciences · doi:10.7150/ijms.36516 · Cited by 130

Curcumin and Resveratrol in the Management of Cognitive Disorders: What is the Clinical Evidence?

Mazzanti, G., & Giacomo, S. D. (2016) · Molecules · doi:10.3390/molecules21091243 · Cited by 131

Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer’s pathology

Haure-Mirande, J.-V., Audrain, M., Fanutza, T., Kim, S. H., Klein, W. L., Glabe, C., Readhead, B., Dudley, J. T., Blitzer, R. D., Wang, M., et al. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1737-3 · Cited by 127

The effect of Nigella sativa Linn. seed on memory, attention and cognition in healthy human volunteers

Sayeed, M. S. B., Asaduzzaman, M., Morshed, H., Hossain, M. M., Kadir, M. F., & Rahman, M. R. (2013) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2013.05.004 · Cited by 131

Synthesis and evaluation of 7-substituted coumarin derivatives as multimodal monoamine oxidase-B and cholinesterase inhibitors for the treatment of Alzheimer's disease

Joubert, J., Foka, G. B., Repsold, B. P., Oliver, D. W., Kapp, E., & Malan, S. F. (2016) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2016.09.041 · Cited by 123

The link of organophosphorus pesticides with neurodegenerative and neurodevelopmental diseases based on evidence and mechanisms

Mostafalou, S., & Abdollahi, M. R. (2018) · Toxicology · doi:10.1016/j.tox.2018.07.014 · Cited by 130

Natural product coumarins: biological and pharmacological perspectives

Hussain, M. I., Syed, Q. A., Khattak, M. N. K., Hafez, B., Reigosa, M. J., & El‐Keblawy, A. A. (2019) · Biologia · doi:10.2478/s11756-019-00242-x · Cited by 126

Telomere Shortening and Alzheimer’s Disease

Cai, Z., Yan, L., & Ratka, A. (2012) · NeuroMolecular Medicine · doi:10.1007/s12017-012-8207-9 · Cited by 121

Synthesis of new donepezil analogues and investigation of their effects on cholinesterase enzymes

Sağlık, B. N., Ilgın, S., & Özkay, Y. (2016) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2016.10.042 · Cited by 117

Neuronal failure in Alzheimer’s disease: a view through the oxidative stress looking-glass

Bonda, D., Wang, X., Lee, H., Smith, M. A., Perry, G. L., & Zhu, X. (2014) · Neuroscience Bulletin · doi:10.1007/s12264-013-1424-x · Cited by 114

Astrocytes as a Therapeutic Target in Alzheimer’s Disease–Comprehensive Review and Recent Developments

Rodríguez-Giraldo, M., González-Reyes, R. E., Ramírez-Guerrero, S., Bonilla-Trilleras, C. E., Guardo-Maya, S., & Nava-Mesa, M. O. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113630 · Cited by 122

Oxidative stress and genetic markers of suboptimal antioxidant defense in the aging brain: A theoretical review

Salminen, L. E., & Paul, R. H. (2014) · Reviews in the Neurosciences · doi:10.1515/revneuro-2014-0046 · Cited by 113

Novel 2-pheynlbenzofuran derivatives as selective butyrylcholinesterase inhibitors for Alzheimer’s disease

Kumar, A., Pintus, F., Petrillo, A. D., Medda, R., Caria, P., Matos, M. J., Viña, D., Pieroni, E., Delogu, F., Era, B., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-22747-2 · Cited by 117

Theories of Aging and the Prevalence of Alzheimer’s Disease

Trevisan, K., Cristina-Pereira, R., Silva-Amaral, D., & Aversi‐Ferreira, T. A. (2019) · BioMed Research International · doi:10.1155/2019/9171424 · Cited by 120

Alzheimer’ s disease, oxidative stress and gammahydroxybutyrate

Mamelak, M. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.06.008 · Cited by 108

Resveratrol activation of AMPK-dependent pathways is neuroprotective in human neural stem cells against amyloid-beta-induced inflammation and oxidative stress

Chiang, M., Nicol, C. J. B., & Cheng, Y. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2017.10.002 · Cited by 110

Design, synthesis, in-silico and biological evaluation of novel donepezil derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease

Mishra, C. B., Kumari, S., Manral, A., Prakash, A., Saini, V., Lynn, A. M., & Tiwari, M. (2016) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2016.09.057 · Cited by 108

Brain Endothelial Cells Synthesize Neurotoxic Thrombin in Alzheimer’s Disease

Yin, X., Wright, J., Wall, T., & Grammas, P. (2010) · The American Journal of Pathology · doi:10.2353/ajpath.2010.090406 · Cited by 104

Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation

Wu, M., Esteban, G., Brogi, S., Shionoya, M., Wang, L., Campiani, G., Unzeta, M., Inokuchi, T., Butini, S., & Marco‐Contelles, J. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2015.10.001 · Cited by 104

Alzheimer’s Disease: Mechanism and Approach to Cell Therapy

Amemori, T., Jendelová, P., Růžička, J., Urdzíková, L. M., & Syková, E. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161125961 · Cited by 110

Triangulated Mal-Signaling in Alzheimer's Disease: Roles of Neurotoxic Ceramides, ER Stress, and Insulin Resistance Reviewed

de la Monte, S. M. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-111727 · Cited by 104

Potential oxidative stress biomarkers of mild cognitive impairment due to Alzheimer disease

García‐Blanco, A., Baquero, M., Vento, M., Gil, E., Bataller, L., & Cháfer‐Pericás, C. (2017) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2017.01.020 · Cited by 102

Multi-target-directed ligands for treating Alzheimer's disease: Butyrylcholinesterase inhibitors displaying antioxidant and neuroprotective activities

Knez, D., Coquelle, N., Pišlar, A. H., Žakelj, S., Jukič, M., Sova, M., Mravljak, J., Nachon, F., Brazzolotto, X., Kos, J., et al. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.07.033 · Cited by 98

Curcumin attenuates paraquat-induced cell death in human neuroblastoma cells through modulating oxidative stress and autophagy

Jaroonwitchawan, T., Chaicharoenaudomrung, N., Namkaew, J., & Noisa, P. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.10.050 · Cited by 97

Plasma protein profiling for potential biomarkers in the early diagnosis of Alzheimer’s disease

Kitamura, Y., Usami, R., Ichihara, S., Kida, H., Satoh, M., Tomimoto, H., Murata, M., & Oikawa, S. (2017) · Neurological Research · doi:10.1080/01616412.2017.1281195 · Cited by 97

Attenuation of β -Amyloid-Induced Oxidative Cell Death by Sulforaphane via Activation of NF-E2-Related Factor 2

Lee, C., Park, G. H., Lee, S., & Jang, J. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/313510 · Cited by 98

Nanoparticle and Iron Chelators as a Potential Novel Alzheimer Therapy

Liu, G., Men, P., Perry, G. L., & Smith, M. A. (2009) · Methods in molecular biology · doi:10.1007/978-1-60327-029-8_8 · Cited by 96

A review on ferulic acid and analogs based scaffolds for the management of Alzheimer’s disease

Singh, Y. P., Rai, H., Singh, G., Singh, G. K., Mishra, S. K., Kumar, S., Srikrishna, S., & Modi, G. P. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113278 · Cited by 98

Urate and risk of Alzheimer's disease and vascular dementia: A population‐based study

Scheepers, L. E. J. M., Jacobsson, L., Kern, S., Johansson, L. H., Dehlin, M., & Skoog, I. G. (2019) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2019.01.014 · Cited by 92

A multifunctional therapeutic approach: Synthesis, biological evaluation, crystal structure and molecular docking of diversified 1H-pyrazolo[3,4-b]pyridine derivatives against Alzheimer's disease

Umar, T., Shalini, S., Raza, M. K., Gusain, S., Kumar, J., Seth, P., Tiwari, M., & Hoda, N. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.04.038 · Cited by 89

Role of Oxidative Stress and Metal Toxicity in the Progression of Alzheimer’s Disease

Birla, H., Minocha, T., Kumar, G., Misra, A., & Singh, S. K. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200122122512 · Cited by 90

Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice

Matthews, D. G., Caruso, M., Murchison, C. F., Zhu, J. Y., Wright, K. M., Harris, C. J., Gray, N. E., Quinn, J. F., & Soumyanath, A. (2019) · Antioxidants · doi:10.3390/antiox8120630 · Cited by 86

Icariin and Its Metabolites as Potential Protective Phytochemicals Against Alzheimer’s Disease

Angeloni, C., Barbalace, M. C., & Hrelia, S. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00271 · Cited by 86

GSK-3β, FYN, and DYRK1A: Master Regulators in Neurodegenerative Pathways

Demuro, S., Martino, R. M. C. D., Ortega, J. A., & Cavalli, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22169098 · Cited by 88

The Potential Role of Cytokines and Growth Factors in the Pathogenesis of Alzheimer’s Disease

Ogunmokun, G., Dewanjee, S., Chakraborty, P., Valupadas, C., Chaudhary, A., Kolli, V., Anand, U., Vallamkondu, J., Goel, P., Paluru, H. P. R., et al. (2021) · Cells · doi:10.3390/cells10102790 · Cited by 85

Cystamine-tacrine dimer: A new multi-target-directed ligand as potential therapeutic agent for Alzheimer’s disease treatment

Minarini, A., Milelli, A., Tumiatti, V., Rosini, M., Simoni, E., Bolognesi, M. L., Andrisano, V., Bartolini, M., Motori, E., Angeloni, C., et al. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.10.007 · Cited by 85

Natural Polysaccharides as Preventive and Therapeutic Horizon for Neurodegenerative Diseases

Dhahri, M., Alghrably, M., Mohammed, H. A., Badshah, S. L., Noreen, N., Mouffouk, F., Rayyan, S., Qureshi, K. A., Mahmood, D., Lachowicz, J. I., et al. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics14010001 · Cited by 86

Tinospora cordifolia (Willd.) Miers: Protection mechanisms and strategies against oxidative stress-related diseases

Arunachalam, K., Yang, X., & San, T. T. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114540 · Cited by 82

Association of Glucose Fluctuations with Sarcopenia in Older Adults with Type 2 Diabetes Mellitus

Ogama, N., Sakurai, T., Kawashima, S., Tanikawa, T., Tokuda, H., Satake, S., Miura, H., Shimizu, A., Kokubo, M., Niida, S., et al. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8030319 · Cited by 84

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Protective effect of daidzein against streptozotocin‐induced Alzheimer's disease via improving cognitive dysfunction and oxidative stress in rat model

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A multitude of signaling pathways associated with Alzheimer's disease and their roles in AD pathogenesis and therapy

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Natural Compounds and Plant Extracts as Therapeutics Against Chronic Inflammation in Alzheimer’s Disease – A Translational Perspective

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Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: Synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine

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Design and synthesis of novel anti-Alzheimer’s agents: Acridine-chromenone and quinoline-chromenone hybrids

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Dietary Polyphenols as Therapeutic Intervention for Alzheimer’s Disease: A Mechanistic Insight

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Synthesis, biological assessment and molecular modeling of new multipotent MAO and cholinesterase inhibitors as potential drugs for the treatment of Alzheimer’s disease

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Hybrid Multifunctional Modulators Inhibit Multifaceted Aβ Toxicity and Prevent Mitochondrial Damage

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Oxidative stress and ion channels in neurodegenerative diseases

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An Expanded Narrative Review of Neurotransmitters on Alzheimer’s Disease: The Role of Therapeutic Interventions on Neurotransmission

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Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease: Insights into Pathophysiology and Treatment

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Plasma lipid peroxidation biomarkers for early and non-invasive Alzheimer Disease detection

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Alzheimer’s Disease, Cholesterol, and Statins: The Junctions of Important Metabolic Pathways

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Positive Feedback Loops in Alzheimer’s Disease: The Alzheimer’s Feedback Hypothesis

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Arsenic Exposure Contributes to the Bioenergetic Damage in an Alzheimer’s Disease Model

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Oxidative Stress and Amyloid Beta Toxicity in Alzheimer’s Disease: Intervention in a Complex Relationship by Antioxidants

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Functional Foods: An Approach to Modulate Molecular Mechanisms of Alzheimer’s Disease

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Oxidative Stress

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The Role of Dietary Antioxidants in the Pathogenesis of Neurodegenerative Diseases and Their Impact on Cerebral Oxidoreductive Balance

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Biochemical deficits and cognitive decline in brain aging: Intervention by dietary supplements

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Investigations on oxidative stress and therapeutical implications in dementia

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Oxidative Stress in Alzheimer’s Disease: Molecular Hallmarks of Underlying Vulnerability

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Euro Neuropharmacology 2018: The oxidative stress initiated mitochondrial DNA over proliferation and deletion in the context of the cancer and neurodegeneration: Recent challenge in Neuropharmacology - Gjumrakch Aliev - University of Atlanta

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Oxidativer Streß in der Pathogenese von Morbus Alzheimer und antioxidative Neuroprotektion

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Glycoxidative stress creates a vicious cycle of neurodegeneration in Alzheimer’s disease — a target for neuroprotective treatment strategies?

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