The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Filopodia and adhesion in cancer cell motility
Open accessAbstract
Slender bundled actin containing plasma membrane protrusions, called filopodia, are important for many essential cellular processes like cell adhesion, migration, angiogenesis and the formation of cell-cell contacts. In migrating cells, filopodia are the pioneers at the leading edge which probe the environment for cues. Integrins are cell surface adhesion receptors critically implicated in cell migration and they are transported actively to filopodia tips by an unconventional myosin, myosin-X. Integrin mediated adhesion stabilizes filopodia and promotes cell migration even though integrins are not essential for filopodia initiation. Myosin-X binds also PIP3 and this regulates its activation and localization to filopodia. Filopodia stimulate cell migration in many cell types and increased filopodia density has been described in cancer. Furthermore, several proteins implicated in filopodia formation, like fascin, are also relevant for cancer progression. To investigate this further, we performed a meta-analysis of the expression profiles of 10 filopodia-linked genes in human breast cancer. These data implicated that several different filopodia inducing genes may contribute in a collective manner to cancer progression and the high metastasis rates associated with basal-type breast carcinomas.
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Hynes (2002) · doi:10.1016/s0092-8674(02)00971-6 · Cited by 8,606
Taking Cell-Matrix Adhesions to the Third Dimension
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Genes that mediate breast cancer metastasis to lung
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The final steps of integrin activation: the end game
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PtdIns(3,4,5)P 3 is a regulator of myosin-X localization and filopodia formation
Plantard, L., Arjonen, A., Lock, J. G., Nurani, G., Ivaska, J., & Strömblad, S. (2010) · Journal of Cell Science · doi:10.1242/jcs.069609 · Cited by 84
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Macrophages, Foreign Body Giant Cells and Their Response to Implantable Biomaterials
Sheikh, Z., Brooks, P., Barzilay, O., Fine, N., & Glogauer, M. (2015) · Materials · doi:10.3390/ma8095269 · Cited by 701
Rho A and Rac1: Antagonists moving forward
Salloum, G., Jaafar, L., & El-Sibai, M. (2020) · Tissue and Cell · doi:10.1016/j.tice.2020.101364 · Cited by 36
Rajendran, B. K., & Deng, C.-X. (2017) · Oncotarget · doi:10.18632/oncotarget.20404 · Cited by 32
Metadata
- Authors
- Arjonen, A., Kaukonen, R., & Ivaska, J.
- Venue
- Cell Adhesion & Migration
- Publisher
- Informa UK Limited
- Published
- 2011-09
- Volume
- 5
- Issue
- 5
- Pages
- 421-430
- ISSN
- 1933-6918 (ISSN-L)
- 1933-6926
- OpenAlex
- W2006292913
- Cited by
- 257
- References
- 8
- FWCI
- 7.49
- Type
- journal article
- Language
- en
- Open access
- gold
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