Cited by 1,209Angiogenesis and VEGF in CancerLymphatic System and DiseasesCancer, Hypoxia, and Metabolism

Angiogenesis

Folkman, Judah·2006·Annual Review of Medicine

Abstract

Angiogenesis inhibitors for the treatment of cancer have now been approved by the Food and Drug Administration in the United States, and in 28 other countries including China. Clinical application of this new class of drugs is informed by certain principles from angiogenesis research. Oncogenic mutations initiate tumorigenesis, but angiogenesis is necessary for expansion of tumor mass. Two angiogenesis inhibitors have been developed that have a broad spectrum of anticancer activity, yet virtually no side effects. Endogenous angiogenesis inhibitors act as tumor suppressor proteins. The angiogenic response in vivo is based on the genetic background of the host. Several types of angiogenesis inhibitors reveal a biphasic, U-shaped curve of efficacy. “Antiangiogenic chemotherapy” is a novel approach to the treatment of drug resistance.

Integrity signals

Registry

Crossref · 10.1146/annurev.med.57.121304.131306

Cites

88 of 88 references verified0 citation errors · 0 not checkable

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  • Angiogenesis is essential for supplying oxygen and nutrients to a growing tumor.

    “First, CCN1 is a powerful angiogenic inducer in vivo [72,83], and angiogenesis is essential for the supply of oxygen and nutrients to nourish the growing tumor [140].”

    From CCN1/CYR61: the very model of a modern matricellular protein (2011) · cites this paper as [140]

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Authors
Folkman, J.
Affiliations
Boston Children's Hospital (US)
Corresponding author
Folkman, Judah
Venue
Annual Review of Medicine
Published
2006-02-01
Volume
57
Issue
1
Pages
1-18
ISSN
  • 0066-4219 (ISSN-L)
  • 1545-326X
OpenAlex
W4230026896
Cited by
1,209
References
88
Citations by year
2026: 19 · 2025: 43 · 2024: 46 · 2023: 49 · 2022: 40 · 2021: 31 · 2020: 42 · 2019: 44 · 2018: 42 · 2017: 48 · 2016: 43 · 2015: 63 · 2014: 72 · 2013: 68 · 2012: 92
FWCI
7.53
Type
journal article
Language
en
Open access
closed
Locations
  • Annual Review of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Cancer Institute (P01CA045548, P0-1 CA-45548, R01CA037395, R01-CA37395)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
  • Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Keywords
angiogenesis inhibitors, cancer therapy, tumor growth, tumor suppressor proteins, host genetic background, drug resistance, oncogenic mutations
MeSH terms
Humans, Neoplasms, Neovascularization, Pathologic, Oncogenes, Angiogenesis Inhibitors

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