Angiogenesis
Abstract
Angiogenesis inhibitors for the treatment of cancer have now been approved by the Food and Drug Administration in the United States, and in 28 other countries including China. Clinical application of this new class of drugs is informed by certain principles from angiogenesis research. Oncogenic mutations initiate tumorigenesis, but angiogenesis is necessary for expansion of tumor mass. Two angiogenesis inhibitors have been developed that have a broad spectrum of anticancer activity, yet virtually no side effects. Endogenous angiogenesis inhibitors act as tumor suppressor proteins. The angiogenic response in vivo is based on the genetic background of the host. Several types of angiogenesis inhibitors reveal a biphasic, U-shaped curve of efficacy. “Antiangiogenic chemotherapy” is a novel approach to the treatment of drug resistance.
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Angiogenesis is essential for supplying oxygen and nutrients to a growing tumor.
“First, CCN1 is a powerful angiogenic inducer in vivo [72,83], and angiogenesis is essential for the supply of oxygen and nutrients to nourish the growing tumor [140].”
From CCN1/CYR61: the very model of a modern matricellular protein (2011) · cites this paper as [140]
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Endometriosis: The Role of Neuroangiogenesis
Asante, A., & Taylor, R. N. (2011) · Annual Review of Physiology · doi:10.1146/annurev-physiol-012110-142158 · Cited by 223 · see citing works
Cancer combination therapies by angiogenesis inhibitors; a comprehensive review
Ansari, M. J., Bokov, D., Markov, A., Jalil, A. T., Shalaby, M. N., Suksatan, W., Chupradit, S., AL-Ghamdi, H. S., Shomali, N., Zamani, A., et al. (2022) · Cell Communication and Signaling · doi:10.1186/s12964-022-00838-y · Cited by 197 · see citing works
Ets1 and ets2 are required for endothelial cell survival during embryonic angiogenesis
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Targeting Vascular NADPH Oxidase 1 Blocks Tumor Angiogenesis through a PPARα Mediated Mechanism
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The Fluid Mechanics of Cancer and Its Therapy
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Elimination of Neoangiogenesis for Plaque Stabilization
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Jumping the barrier: VE‐cadherin, VEGF and other angiogenic modifiers in cancer
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Marine-derived angiogenesis inhibitors for cancer therapy
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Lack of thrombospondin 1 and exacerbation of choroidal neovascularization
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HDAC in obesity: A critical insight
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- Authors
- Folkman, J.
- Affiliations
- Boston Children's Hospital (US)
- Corresponding author
- Folkman, Judah
- Venue
- Annual Review of Medicine
- Publisher
- Annual Reviews
- Published
- 2006-02-01
- Volume
- 57
- Issue
- 1
- Pages
- 1-18
- ISSN
- 0066-4219 (ISSN-L)
- 1545-326X
- OpenAlex
- W4230026896
- Cited by
- 1,209
- References
- 88
- Citations by year
- 2026: 19 · 2025: 43 · 2024: 46 · 2023: 49 · 2022: 40 · 2021: 31 · 2020: 42 · 2019: 44 · 2018: 42 · 2017: 48 · 2016: 43 · 2015: 63 · 2014: 72 · 2013: 68 · 2012: 92
- FWCI
- 7.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (P01CA045548, P0-1 CA-45548, R01CA037395, R01-CA37395)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Keywords
- angiogenesis inhibitors, cancer therapy, tumor growth, tumor suppressor proteins, host genetic background, drug resistance, oncogenic mutations
- MeSH terms
- Humans, Neoplasms, Neovascularization, Pathologic, Oncogenes, Angiogenesis Inhibitors
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