The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Autophagy as a therapeutic target in cancer
Open accessAbstract
Autophagy is a self-catabolic process that maintains intracellular homeostasis and prolongs cell survival under stress via lysosomal degradation of cytoplasmic constituents and recycling of amino acids and energy. Autophagy is intricately involved in many aspects of human health and disease, including cancer. Autophagy is a double-edged sword in tumorigenesis, acting both as a tumor suppressor and a protector of cancer cell survival, and elucidation of its exact role at different stages of cancer progression and in treatment responsiveness is a complex and challenging task. Better understanding of autophagy regulation and its impact on treatment outcome will potentially allow us to identify novel therapeutic targets in cancer. In this review, we summarize current knowledge on the regulation and dual function of autophagy in tumorigenesis, as well as ongoing efforts in modulating autophagy for cancer treatment and prevention. This is a very exciting and highly promising area of cancer research, as pharmacologic modulation of autophagy appears to augment the efficacy of currently available anticancer regimens and opens the way to the development of new combinatorial therapeutic strategies that will hopefully contribute to cancer eradication.
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Cites
Autophagy in the Pathogenesis of Disease
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Autophagy fights disease through cellular self-digestion
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AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
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Autophagy and the Integrated Stress Response
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Induction of autophagy and inhibition of tumorigenesis by beclin 1
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Cited by
Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice
Michaud, M., Martins, I., Sukkurwala, A. Q., Adjemian, S., Ma, Y., Pellegatti, P., Shen, S., Kepp, O., Scoazec, M., Mignot, G., et al. (2011) · Science · doi:10.1126/science.1208347 · Cited by 1,377
Structure and dynamics of molecular networks: A novel paradigm of drug discovery
Csermely, P., Korcsmáros, T., Kiss, H. J. M., London, G., & Nussinov, R. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.01.016 · Cited by 892
Targeting the RAS/RAF/MAPK pathway for cancer therapy: from mechanism to clinical studies
Bahar, M. E., Kim, H. J., & Kim, D. R. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01705-z · Cited by 888
Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy
Maycotte, P., Aryal, S., Cummings, C. T., Thorburn, J., Morgan, M. J., & Thorburn, A. (2012) · Autophagy · doi:10.4161/auto.8.2.18554 · Cited by 401
microRNA‐101 is a potent inhibitor of autophagy
Frankel, L. B., Wen, J., Lees, M., Høyer‐Hansen, M., Farkas, T., Krogh, A., Jäättelä, M., & Lund, A. H. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.331 · Cited by 312
Metadata
- Authors
- Chen, N., & Karantza, V.
- Venue
- Cancer Biology & Therapy
- Publisher
- Informa UK Limited
- Published
- 2011-01-15
- Volume
- 11
- Issue
- 2
- Pages
- 157-168
- ISSN
- 1538-4047 (ISSN-L)
- 1555-8576
- OpenAlex
- W2038592957
- Cited by
- 303
- References
- 37
- FWCI
- 22.69
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
