pRb2/p130 and VEGF expression in endometrial carcinoma in relation to angiogenesis and histopathologic tumor grade
Open accessAbstract
PURPOSE: Endometrial cancer is the most common gynecologic malignancy. Established prognostic factors are histologic grade, depth of myometrial invasion, and extrauterine spread including retroperitoneal lymph node metastases. Tumorigenesis is a multistep process involving different genetic changes resulting in uncontrolled cellular proliferation, inhibition of apoptosis, and enhanced vascular proliferation among other events. Angiogenesis, the formation of new blood vessels from a preexisting vascular network, is necessary for invasive tumor growth and metastasis and constitutes an important point in the control of cancer progression. The pathogenesis of the angiogenetic phenotype may involve the inactivation of different tumor suppressor genes. EXPERIMENTAL DESIGN: We investigated the relationship between the expression levels of VEGF and the retinoblastoma family member pRb2/p130 in endometrial carcinoma in relation to histopathologic tumor grade in a cohort of 50 patients. RESULTS: We found that VEGF and pRB2/p130 expression were inversely correlated. Additionally, high grade tumors presented a significantly lower number of cells expressing pRb2/p130 when compared to low grade tumors. A significant positive correlation was found, by means of the Spearman coefficient, between VEGF expression and binary grading (0.450, p-value < 0.005) which is an architectural grading system that uses low-magnification assessment of amount of solid growth, pattern of invasion, and presence of necrosis to divide endometrioid carcinomas into low- and high-grade tumors. Additionally, we also found a negative correlation between pRb2/p130 expression levels and binary grading (-0.595, p-value < 0.005). Interestingly, we also found that VEGF and pRb2/p130 expression levels were not related to staging (p-value > 0.005). CONCLUSIONS: These results open up a new perspective including novel markers that, combined together, may be useful in patient screening for endometrial cancer aggressiveness.
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Altered RB expression correlates with higher grade, poorly differentiated gastrointestinal cancers.
“Altered RB expression has been observed to be correlated with higher grade, poorly differentiated gastrointestinal cancers99.”
From Cellular mechanisms of tumour suppression by the retinoblastoma gene (2008) · cites this paper as [99]
Changes in RB expression are significantly associated with invasion and metastasis in oesophageal cancers.
“Altered RB expression patterns have been observed in poorly differentiated, metastatic hepatocellular carcinomas137, and correlative analyses have suggested that changes in RB expression are significantly associated with invasion and metastasis of oesophageal cancers99.”
From Cellular mechanisms of tumour suppression by the retinoblastoma gene (2008) · cites this paper as [99]
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- Authors
- Sanseverino, F., Santopietro, R., Torricelli, M., D'Andrilli, G., Russo, G., Cevenini, G., Bovicelli, A., Leoncini, L., Scambia, G., Petraglia, F., Claudio, P. P., & Giordano, A.
- Affiliations
- University of Siena (IT)
- Temple University (US)
- Università Cattolica del Sacro Cuore (IT)
- Corresponding author
- Giordano, Antonio
- ORCID
- Venue
- Cancer Biology & Therapy
- Publisher
- Informa UK Limited
- Published
- 2006-01-16
- Volume
- 5
- Issue
- 1
- Pages
- 84-88
- ISSN
- 1538-4047 (ISSN-L)
- 1555-8576
- OpenAlex
- W2069011214
- Cited by
- 32
- References
- 26
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2016: 3 · 2015: 3 · 2014: 2 · 2013: 2 · 2012: 1
- FWCI
- 1.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cancer Biology & Therapy (publishedVersion)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Florence Research (University of Florence) (submittedVersion)
- Use Siena air (University of Siena) (submittedVersion)
- INFM-OAR (INFN Catania) (submittedVersion, other-oa)
- Funders
- Associazione Italiana per la Ricerca sul Cancro
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
- Health Sciences › Medicine › Reproductive Medicine › Ovarian cancer diagnosis and treatment
- Keywords
- endometrial cancer, vascular endothelial growth factor, tumor angiogenesis, tumor suppressor, prognostic factors, endometrioid carcinoma, tumor aggressiveness
- MeSH terms
- Female, Humans, Neoplasm Staging, Prognosis, Biomarkers, Tumor, Endometrial Neoplasms, Carcinoma, Endometrioid, Vascular Endothelial Growth Factor A, Retinoblastoma-Like Protein p130
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