Involvement of RB gene family in tumor angiogenesis

Gabellini, C; Del Bufalo, D; Zupi, G

doi:10.1038/sj.onc.1209631

Cited by 47Angiogenesis and VEGF in CancerCancer-related Molecular PathwaysTGF-β signaling in diseases

Involvement of RB gene family in tumor angiogenesis

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Gabellini, C, Del Bufalo, D, Zupi, G·2006·Oncogene

DOI 10.1038/sj.onc.1209631

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Abstract

Angiogenesis, the development of new blood vessels from pre-existing vessels, represents a fundamental step in tumor progression and metastatization. The induction of vasculature is required for growth of the tumor mass, to ensure an adequate supply of oxygen and metabolites to the tumor beyond a critical size. Tumor angiogenesis is a highly regulated process that is controlled physiologically by the tumor microenvironment and genetically by alteration of several oncogenes or tumor suppressor genes. We will focus on recent demonstrations regarding the involvement of the retinoblastoma family proteins (phosphorylated retinoblastoma (pRb), p107 and pRb2/p130) at different levels of the angiogenic process. pRb and its homologs can regulate the expression of pro- and antiangiogenic factors, such as the vascular endothelial growth factor, through an E2F-dependent mechanism. Moreover, pRb is able to modulate also the transcriptional activity of several angiogenesis-related factors like HIF-1, Id2 and Oct-1. pRb2/p130 is required for both differentiation and mobilization of bone marrow-derived endothelial cell precursors and endothelial sprouting from neighboring vessels. The involvement of the pRb pathway in the angiogenesis process has also been demonstrated by different cellular models expressing viral oncoproteins, like human papilloma virus. Moreover, some natural and synthetic compounds demonstrate their antiangiogenetic activity with a mechanism of action involving pRb. Finally, the possible prognostic value of immunohistochemical evaluation of pRb and/or pRb2/p130 expression can represent a useful tool for the characterization of the angiogenic phenotype of specific tumor histotypes.

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The RB-E2F pathway transcriptionally targets VEGF and other angiogenic factors that tumours secrete to attract endothelial cells.
“Emerging evidence shows that vascular endothelial growth factor (VEGF) and other angiogenic factors that are secreted by tumour cells to recruit endothelial cells are transcriptional targets of the RB–E2F pathway130.”
From Cellular mechanisms of tumour suppression by the retinoblastoma gene (2008) · cites this paper as [130]

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BIOLOGY
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Authors: Gabellini, C., Del Bufalo, D., & Zupi, G.
Affiliations: Instituto Nazionale Tumori Regina Elena (IT)
Corresponding author: Zupi, G
ORCID: Gabellini, C
Venue: Oncogene
Publisher: Springer Science and Business Media LLC
Published: 2006-08-28
Volume: 25
Issue: 38
Pages: 5326-5332
ISSN: 0950-9232 (ISSN-L)
1476-5594
DOI: 10.1038/sj.onc.1209631
OpenAlex: W2029323847
Cited by: 47
References: 98
Citations by year: 2020: 1 · 2019: 1 · 2017: 2 · 2016: 4 · 2015: 6 · 2014: 2 · 2013: 4 · 2012: 4
FWCI: 0.34
Type: journal article
Language: en
Open access: green
www.openaccessrepository.it
Licence: other-oa
www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Oncogene (publishedVersion)
PubMed (publishedVersion)
CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
INFM-OAR (INFN Catania) (submittedVersion, other-oa)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Keywords: tumor angiogenesis, retinoblastoma protein, p107, pRb2/p130, vascular endothelial growth factor, HIF-1, Id2, Oct-1, anti-angiogenic compounds, prognostic factors, tumor microenvironment
MeSH terms: Multigene Family, Humans, Neoplasms, Neovascularization, Pathologic, Retinoblastoma, Transcription Factors, Genes, Retinoblastoma, Retinal Neoplasms, Angiogenesis Inducing Agents

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Involvement of RB gene family in tumor angiogenesis

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