The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
DNA methylation regulates microRNA expression
Open accessAbstract
MicroRNAs (miRNAs), an important class of small regulatory molecules for gene expression, are transcribed by RNA polymerase II. But little is known about the mechanisms that control miRNA expression. Comparing miRNA expression profiles between colon cancer cell line HCT 116 and its derivative, DNA methyltransferase 1 and 3b (DNMT1 and DNMT3b) double knockout cell line, we found that the expression of about 10% miRNAs was regulated by DNA methylation. In addition, neither 5-aza-2'-deoxycytidine treatment nor deletion of DNMT1 alone recapitulated miRNA expression profile seen in the double knockout cell line, suggesting that miRNA expression was tightly controlled by DNA methylation and partial methylation reduction was not sufficient for miRNA reexpression. We also found that HOXA3 and HOXD10 were putative targets of mir-10a, one of the differentially expressed miRNAs that is located in HOX gene cluster.
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MicroRNA genes are transcribed by RNA polymerase II
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A microRNA polycistron as a potential human oncogene
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c-Myc-regulated microRNAs modulate E2F1 expression
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MicroRNA-Directed Cleavage of HOXB8 mRNA
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Reduced accumulation of specific microRNAs in colorectal neoplasia.
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A Genetic Screen Implicates miRNA-372 and miRNA-373 As Oncogenes in Testicular Germ Cell Tumors
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DNMT1 and DNMT3b cooperate to silence genes in human cancer cells
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Cited by
DNA methylation and its basic function
Moore, L. D., Le, T., & Fan, G. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.112 · Cited by 4,906
The widespread regulation of microRNA biogenesis, function and decay
Krol, J., Loedige, I., & Filipowicz, W. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2843 · Cited by 4,672
MicroRNA: Biogenesis, Function and Role in Cancer
MacFarlane, L.-A., & R. Murphy, P. (2010) · Current Genomics · doi:10.2174/138920210793175895 · Cited by 1,584
A microRNA DNA methylation signature for human cancer metastasis
Lujambio, A., Calin, G. A., Villanueva, A., Ropero, S., Sánchez-Céspedes, M., Blanco, D., Montuenga, L. M., Rossi, S., Nicoloso, M. S., Faller, W. J., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803055105 · Cited by 1,078
The Hox genes and their roles in oncogenesis
Shah, N., & Sukumar, S. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2826 · Cited by 835
Self-citation
Metadata
- Authors
- Han, L., Witmer, P. D. W., Casey, E., Valle, D., & Sukumar, S.
- Venue
- Cancer Biology & Therapy
- Publisher
- Informa UK Limited
- Published
- 2007-08
- Volume
- 6
- Issue
- 8
- Pages
- 1290-1294
- ISSN
- 1538-4047 (ISSN-L)
- 1555-8576
- OpenAlex
- W2138513791
- Cited by
- 332
- References
- 17
- FWCI
- 5.75
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Han, L., Witmer, P. D. W., Casey, E., Valle, D., & Sukumar, S. (2007). DNA methylation regulates microRNA expression. Cancer Biology & Therapy. https://doi.org/10.4161/cbt.6.8.4486
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
