The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Characterization of the cell of origin for small cell lung cancer
Open accessAbstract
Small cell lung carcinoma (SCLC) is a neuroendocrine subtype of lung cancer that affects more than 200,000 people worldwide every year with a very high mortality rate. Here, we used a mouse genetics approach to characterize the cell of origin for SCLC; in this mouse model, tumors are initiated by the deletion of the Rb and p53 tumor suppressor genes in the lung epithelium of adult mice. We found that mouse SCLCs often arise in the lung epithelium, where neuroendocrine cells are located, and that the majority of early lesions were composed of proliferating neuroendocrine cells. In addition, mice in which Rb and p53 are deleted in a variety of non-neuroendocrine lung epithelial cells did not develop SCLC. These data indicate that SCLC likely arises from neuroendocrine cells in the lung.
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Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry
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An oncogenic KRAS2 expression signature identified by cross-species gene-expression analysis.
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Differentiated Horizontal Interneurons Clonally Expand to Form Metastatic Retinoblastoma in Mice
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Ireland, A. S., Micinski, A. M., Kastner, D. W., Guo, B., Wait, S. J., Spainhower, K. B., Conley, C. C., Chen, O. S., Guthrie, M. R., Soltero, D., et al. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.05.001 · Cited by 508
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Metadata
- Authors
- Park, K.-S., Liang, M.-C., Raiser, D. M., Zamponi, R., Roach, R. R., Curtis, S. J., Walton, Z., Schaffer, B. E., Roake, C. M., Zmoos, A.-F., Kriegel, C., Wong, K.-K., Sage, J., & Kim, C. F.
- Venue
- Cell Cycle
- Publisher
- Informa UK Limited
- Published
- 2011-08-15
- Volume
- 10
- Issue
- 16
- Pages
- 2806-2815
- ISSN
- 1538-4101 (ISSN-L)
- 1551-4005
- OpenAlex
- W2016722600
- Cited by
- 227
- References
- 8
- FWCI
- 3.03
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Park, K.-S., Liang, M.-C., Raiser, D. M., Zamponi, R., Roach, R. R., Curtis, S. J., Walton, Z., Schaffer, B. E., Roake, C. M., Zmoos, A.-F., Kriegel, C., Wong, K.-K., Sage, J., & Kim, C. F. (2011). Characterization of the cell of origin for small cell lung cancer. Cell Cycle. https://doi.org/10.4161/cc.10.16.17012
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