Role of Rb Family in the Epigenetic Definition of Chromatin
Open accessAbstract
Epigenetic changes can influence a variety of cellular processes from regulation of gene transcription to proper chromosome segregation. The molecular activities that dictate the assembly, maintenance and regulation of chromatin structure are beginning to be identified. A recent study demonstrates that the Rb family of tumor suppressors plays a major role in global chromatin structure. In addition to the well-known function of Rb family inducing a repressive chromatin state around euchromatic promoters, Rb proteins have a direct role in the assembly of pericentric and telomeric heterochromatin domains. In particular, the Rb family maintains histone 4 lysine 20 tri-methylation (H4K20) at these constitutive heterochromatin domains. Lack of the Rb family results in decreased H4K20 tri-methylation, coincidental with chromosome segregation defects and abnormal telomere elongation, two processes frequently altered in human cancer. Maintenance of heterochromatic domains, such as those of centromeres and telomeres, may represent a novel tumor suppressor function for the Rb family by ensuing genomic stability.
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RB is an adaptor protein that recruits chromatin remodelling enzymes to control specific target genes and modify chromatin structure chromosome-wide.
“Furthermore, RB is also an adaptor protein that recruits chromatin remodelling enzymes to control the expression of specific target genes and to modify chromatin structure at a chromosome-wide level13,14”
From Cellular mechanisms of tumour suppression by the retinoblastoma gene (2008) · cites this paper as [13]
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CONSTITUTIVE AND SOMATIC GENETIC EVENTS IN RETINOMA AND RETINOBLASTOMA
Sampieri, K. (2008)
- Authors
- Gonzalo, S., & Blasco, M. A.
- Affiliations
- Spanish National Cancer Research Centre (ES)
- ORCID
- Gonzalo, Susana
- Venue
- Cell Cycle
- Publisher
- Informa UK Limited
- Published
- 2005-04-08
- Volume
- 4
- Issue
- 6
- Pages
- 752-755
- ISSN
- 1538-4101 (ISSN-L)
- 1551-4005
- OpenAlex
- W2085216724
- Cited by
- 112
- References
- 0
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 6 · 2020: 1 · 2019: 3 · 2018: 5 · 2017: 4 · 2016: 6 · 2015: 6 · 2014: 4 · 2013: 9 · 2012: 10
- FWCI
- 2.26
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cell Cycle (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- European Commission (LSHC-CT-2003-506803, FOOD-CT-2003-506850)
- Ministerio de Ciencia y Tecnología
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- retinoblastoma protein, chromatin structure, heterochromatin, telomeres, centromere, H4K20 trimethylation, tumor suppressor function, chromosome segregation, telomere elongation, genome stability, transcriptional regulation
- MeSH terms
- Multigene Family, Heterochromatin, Humans, Promoter Regions, Genetic, Retinoblastoma Protein, Chromatin Assembly and Disassembly, Epigenesis, Genetic
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