The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
TAZ: A β-Catenin-like Molecule that Regulates Mesenchymal Stem Cell Differentiation
Open accessAbstract
Regulating the switch between proliferation and differentiation of mesenchymal stem cells is critical for the development of normal tissues, and the prevention of tumors. How mesenchymal stem cells exit from the cell cycle and differentiate into alternative cell fates such as bone, fat, and muscle, is incompletely understood. We recently discovered that a WW domain-containing molecule, TAZ, functions as a transcriptional modulator to stimulate bone development while simultaneous blocking the differentiation of mesenchymal stem cells into fat. These developmental effects occur through direct interaction between TAZ and the transcription factors Runx2 and PPARgamma, resulting in transcriptional enhancement and repression, respectively of selective programs of gene expression. We propose that TAZ, as well as a highly related molecule YAP, are functionally, though not structurally, similar to beta-catenin and integrate extracellular, membrane, and cytoskeletal-derived signals to influence mesenchymal stem cell fate.
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Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation
Dor, Y., Brown, J., Martinez, O. I., & Melton, D. A. (2004) · Nature · doi:10.1038/nature02520 · Cited by 2,219
Canonical WNT Signaling Promotes Osteogenesis by Directly Stimulating Runx2 Gene Expression
Gaur, T., Lengner, C. J., Hovhannisyan, H., Bhat, R. A., Bodine, P. V. N., Komm, B. S., Javed, A., van Wijnen, A. J., Stein, J. L., Stein, G. S., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500608200 · Cited by 1,170
Basu, S., Totty, N. F., Irwin, M. S., Sudol, M., & Downward, J. (2003) · Molecular Cell · doi:10.1016/s1097-2765(02)00776-1 · Cited by 843
Vassilev, A., Kaneko, K. J., Shu, H., Zhao, Y., & DePamphilis, M. L. (2001) · Genes & Development · doi:10.1101/gad.888601 · Cited by 719
Sudol, M., Bork, P., Einbond, A., Kastury, K., Druck, T., Negrini, M., Huebner, K., & Lehman, D. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.24.14733 · Cited by 342
Cited by
Liu, C.-Y., Zha, Z.-Y., Zhou, X., Zhang, H., Huang, W., Zhao, D., Li, T., Chan, S. W., Lim, C. J., Hong, W., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.152942 · Cited by 525
A Role for TAZ in Migration, Invasion, and Tumorigenesis of Breast Cancer Cells
Chan, S. W., Lim, C. J., Guo, K., Ng, C. P., Lee, I., Hunziker, W., Zeng, Q., & Hong, W. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2696 · Cited by 478
Muruganandan, S., Roman, A. A., & Sinal, C. J. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8429-z · Cited by 458
Makita, R., Uchijima, Y., Nishiyama, K., Amano, T., Chen, Q., Takeuchi, T., Mitani, A., Nagase, T., Yatomi, Y., Aburatani, H., et al. (2008) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00201.2007 · Cited by 293
Prospective Review of Mesenchymal Stem Cells Differentiation into Osteoblasts
Garg, P., Mazur, M. M., Buck, A. C., Wandtke, M. E., Liu, J., & Ebraheim, N. A. (2017) · Orthopaedic Surgery · doi:10.1111/os.12304 · Cited by 190
Metadata
- Authors
- Hong, J.-H., & Yaffe, M. B.
- Venue
- Cell Cycle
- Publisher
- Informa UK Limited
- Published
- 2005-12-16
- Volume
- 5
- Issue
- 2
- Pages
- 176-179
- ISSN
- 1538-4101 (ISSN-L)
- 1551-4005
- OpenAlex
- W2116517031
- Cited by
- 162
- References
- 5
- FWCI
- 2.35
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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