TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm

Vassilev, Alex; Kaneko, Kotaro J.; Shu, Hongjun; Zhao, Yingming; DePamphilis, Melvin L.

doi:10.1101/gad.888601

Cited by 719Hippo pathway signaling and YAP/TAZGenomics and Chromatin DynamicsProtein Kinase Regulation and GTPase Signaling

TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm

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Vassilev, Alex, Kaneko, Kotaro J., Shu, Hongjun, Zhao, Yingming, DePamphilis, Melvin L.·2001·Genes & Development

DOI 10.1101/gad.888601PMC PMC313800

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Abstract

Mammals express four highly conserved TEAD/TEF transcription factors that bind the same DNA sequence, but serve different functions during development. TEAD-2/TEF-4 protein purified from mouse cells was associated predominantly with a novel TEAD-binding domain at the amino terminus of YAP65, a powerful transcriptional coactivator. YAP65 interacted specifically with the carboxyl terminus of all four TEAD proteins. Both this interaction and sequence-specific DNA binding by TEAD were required for transcriptional activation in mouse cells. Expression of YAP in lymphocytic cells that normally do not support TEAD-dependent transcription (e.g., MPC11) resulted in up to 300-fold induction of TEAD activity. Conversely, TEAD overexpression squelched YAP activity. Therefore, the carboxy-terminal acidic activation domain in YAP is the transcriptional activation domain for TEAD transcription factors. However, whereas TEAD was concentrated in the nucleus, excess YAP65 accumulated in the cytoplasm as a complex with the cytoplasmic localization protein, 14-3-3. Because TEAD-dependent transcription was limited by YAP65, and YAP65 also binds Src/Yes protein tyrosine kinases, we propose that YAP65 regulates TEAD-dependent transcription in response to mitogenic signals.

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Yap and Taz are transcriptional co-activators that regulate gene expression mainly by co-activating Tead transcription factors.
“The ubiquitous transcriptional co-activators Yap (gene symbol Yap1 ) and Taz (gene symbol 36 Wwtr1 ) regulate gene expression mainly by co-activating the Tead transcription factors.”
From The Hippo signal transduction network for exercise physiologists (2016) · cites this paper as [138]
The section “YAP is a general transcriptional coactivator for TEAD transcription factors” identifies YAP as a TEAD coactivator in mammalian cells. “Regulation of TEAD activity” calls TAZ a coactivator homologous to YAP, but does not establish that TAZ coactivates TEAD. The paper also does not show that either protein regulates gene expression mainly through TEAD; its predominance claim concerns YAP as an activation domain for TEAD, not TEAD as YAP’s main partner. (LLM, conf=0.88)
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Authors: Vassilev, A., Kaneko, K. J., Shu, H., Zhao, Y., & DePamphilis, M. L.
Affiliations: National Institutes of Health (US)
ORCID: Vassilev, Alex
Kaneko, Kotaro J.
Zhao, Yingming
DePamphilis, Melvin L.
Venue: Genes & Development
Publisher: Cold Spring Harbor Laboratory
Published: 2001-05-15
Volume: 15
Issue: 10
Pages: 1229-1241
ISSN: 0890-9369 (ISSN-L)
1549-5477
DOI: 10.1101/gad.888601
PMC: PMC313800
OpenAlex: W2159196011
Cited by: 719
References: 37
Citations by year: 2026: 19 · 2025: 31 · 2024: 38 · 2023: 34 · 2022: 43 · 2021: 37 · 2020: 45 · 2019: 50 · 2018: 49 · 2017: 41 · 2016: 46 · 2015: 36 · 2014: 33 · 2013: 31 · 2012: 37
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Genes & Development (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Keywords: transcriptional coactivator, transactivation domain, 14-3-3 proteins, cytoplasmic localization, mitogenic signaling, lymphocytes, transcriptional regulation
MeSH terms: YAP-Signaling Proteins, TEA Domain Transcription Factors, Animals, Carrier Proteins, Cytoplasm, DNA-Binding Proteins, Electrophoresis, Polyacrylamide Gel, Fluorescent Antibody Technique, Phosphoproteins, Protein Binding, Mass Spectrometry, Subcellular Fractions, Transcription Factors, Transcriptional Activation, 3T3 Cells, Protein Structure, Tertiary, Cell Cycle Proteins, src-Family Kinases, Dimerization, Adaptor Proteins, Signal Transducing, Mice

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TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm

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