The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
p38α: A Suppressor of Cell Proliferation and Tumorigenesis
Open accessAbstract
The mitogen-activated protein kinase (MAPK) p38alpha is involved in numerous biological processes and is a drug target for inflammation-associated diseases. Genetic analysis in mice demonstrated that fetuses lacking p38alpha are embryonic lethal owing to impaired placental development. The function of p38alpha in mice after birth remained unclear until conditional alleles of p38alpha were used. It was found that p38alpha is essential for lung function in both neonatal and adult mice. Increased proliferation and impaired differentiation are the hallmarks of p38alpha-deficient cells. Moreover, mice deficient in p38alpha are prone to cancer development using carcinogen or oncogene-induced cancer models. p38alpha can suppress cell proliferation by antagonizing the JNK/c-Jun pathway, which is an important regulator of proliferation and apoptosis. These findings suggest that therapeutic inhibition of p38 might lead to unwanted proliferation. Therefore, a combined inhibition of p38 and other pathways, such as the JNK pathway, should be considered for targeting cancer inflammation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
PRAK Is Essential for ras-Induced Senescence and Tumor Suppression
Sun, P., Yoshizuka, N., New, L., Moser, B. A., Li, Y., Liao, R., Xie, C., Chen, J., Deng, Q., Yamout, M., et al. (2007) · Cell · doi:10.1016/j.cell.2006.11.050 · Cited by 321
c-Jun/AP-1 controls liver regeneration by repressing p53/p21 and p38 MAPK activity
Stepniak, E., Ricci, R., Eferl, R., Sumara, G., Sumara, I., Rath, M., Hui, L., & Wagner, E. F. (2006) · Genes & Development · doi:10.1101/gad.390506 · Cited by 232
Self-citation
Cited by
MAPK signaling in inflammation-associated cancer development
Huang, P., Han, J., & Hui, L. (2010) · Protein & Cell · doi:10.1007/s13238-010-0019-9 · Cited by 273
Self-citationChronic Obstructive Pulmonary Disease and Lung Cancer: New Molecular Insights
Adcock, I. M., Caramori, G., & Barnes, P. J. (2011) · Respiration · doi:10.1159/000324601 · Cited by 257
Batlle, R., Andrés, E., Gonzalez, L., Llonch, E., Igea, A., Gutierrez-Prat, N., Berenguer-Llergo, A., & Nebreda, A. R. (2019) · Nature Communications · doi:10.1038/s41467-019-10946-y · Cited by 142
Systemic problems: a perspective on stem cell aging and rejuvenation.
Conboy, I. M., Conboy, M. J., & Rebo, J. (2015) · Aging · doi:10.18632/aging.100819 · Cited by 58
Effect of a p38 Mitogen-Activated Protein Kinase Inhibitor on Corneal Endothelial Cell Proliferation
Nakahara, M., Okumura, N., Nakano, S., & Koizumi, N. (2018) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.18-24394 · Cited by 30
Metadata
- Authors
- Hui, L., Bakiri, L., Stepniak, E., & Wagner, E. F.
- Venue
- Cell Cycle
- Publisher
- Informa UK Limited
- Published
- 2007-10-15
- Volume
- 6
- Issue
- 20
- Pages
- 2429-2433
- ISSN
- 1538-4101 (ISSN-L)
- 1551-4005
- OpenAlex
- W1986735026
- Cited by
- 183
- References
- 2
- FWCI
- 3.95
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: p38α: A Suppressor of Cell Proliferation and Tumorigenesis. https://app.cochat.ai/papers/10.4161/cc.6.20.4774
- The paper
- Hui, L., Bakiri, L., Stepniak, E., & Wagner, E. F. (2007). p38α: A Suppressor of Cell Proliferation and Tumorigenesis. Cell Cycle. https://doi.org/10.4161/cc.6.20.4774
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
