The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Systemic problems: a perspective on stem cell aging and rejuvenation.
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The general conclusion of heterochronic parabiosis studies was that old partners had better health and/or repair of cartilage, muscle, liver, brain, spinal cord, kidneys, bone, skin, etc.
“The general conclusion of these studies was that the old partners had better health and/or repair of cartilage, muscle, liver, brain, spinal cord, kidneys, bone, skin, etc.”
From Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin (2020) · cites this paper as [7]
The Prologue reports better cartilage health in old rats paired with young rats and rejuvenation of stem cells in muscle, brain/hippocampus, and liver. The paper does not report improved repair of spinal cord, kidneys, bone, or skin in old partners; mentioning young kidneys as a possible benefit to the pair is not evidence of kidney repair. (LLM, conf=0.86)
Experimental — accuracy not yet measuredNeurogenesis in the subgranular zone of the hippocampus continues throughout adult life, dramatically declines with advanced age and is influenced by blood heterochronicity.
“Neurogenesis in the subgranular zone (SGZ) of the hippocampus continues throughout adult life, dramatically declines with advanced age and is influenced by blood heterochronicity [7, 9, 14, 26].”
From Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin (2020) · cites this paper as [7]
The Prologue’s Figure 1 caption reports a marked reduction in hippocampal neurogenesis in old mice and shows that heterochronic pairing changes neural stem-cell proliferation. It examines the dentate gyrus, but does not specifically identify the subgranular zone or establish that neurogenesis continues throughout adult life. (LLM, conf=0.84)
Experimental — accuracy not yet measuredAttenuation of TGF-beta signaling in old animals has effects similar to those of NBE.
“and the fact that attenuation of TGF-beta signaling in old animals has effects that are similar to those of NBE [7, 14, 15, 28, 44].”
From Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin (2020) · cites this paper as [7]
The Concluding remarks (page not provided) report that a TGF-beta receptor inhibitor rejuvenated muscle formation and hippocampal neurogenesis and reduced an inflammation marker in an old animal. The paper does not compare those effects with NBE; its discussion of blood-based rejuvenation concerns heterochronic parabiosis and young plasma, so the claimed similarity to NBE is not established by this source. (LLM, conf=0.85)
Experimental — accuracy not yet measuredIn heterochronic parabiosis studies, young animals often experienced premature aging of their respective tissues.
“and often the young animals experienced premature aging of their respective tissues [1, 3, 4, 6–8].”
From Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin (2020) · cites this paper as [7]
Old human serum strongly reduced myogenic cell proliferation.
“As demonstrated in Figure 2, old human serum strongly reduced myogenic cell proliferation (which is consistent with the effects of the old mouse serum [1, 2, 6, 7, 13]).”
From Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin (2020) · cites this paper as [7]
The original work on rejuvenation of old animals and aging of young through heterochronic parabiosis showed effects not only for skeletal muscle, but also for liver and brain-hippocampal neurogenesis.
“In the original work on rejuvenation of old animals and aging of young through heterochronic parabiosis, the effects were shown not only for skeletal muscle, but also for the liver and brain-hippocampal neurogenesis [1, 7].”
From Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin (2020) · cites this paper as [7]
Heterochronic blood sharing rejuvenates old tissues.
“Heterochronic blood sharing rejuvenates old tissues”
From Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin (2020) · cites this paper as [7]
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Citations
Cites
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Self-citationYoung blood reverses age-related impairments in cognitive function and synaptic plasticity in mice
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ResultThe aged niche disrupts muscle stem cell quiescence
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Self-citationRejuvenation of Regeneration in the Aging Central Nervous System
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Muscle transplantation between young and old rats: age of host determines recovery
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Self-citationMuscle stem cells contribute to myofibres in sedentary adult mice
Keefe, A. C., Lawson, J. A., Flygare, S. D., Fox, Z. D., Colasanto, M. P., Mathew, S. J., Yandell, M., & Kardon, G. (2015) · Nature Communications · doi:10.1038/ncomms8087 · Cited by 279 · cited 1×
“Despite semantics, this does not exclude contribution of muscle stem cells to this tissue even in sedentary mice [84] or the effects of their functional decline with aging particularly when muscle needs rebuilding upon exercise or attrition [85, 86].”
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Deblon, N., Veyrat-Durebex, C., Bourgoin, L., Caillon, A., Bussier, A.-L., Petrosino, S., Piscitelli, F., Legros, J.-J., Geenen, V., Foti, M., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025565 · Cited by 254
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Age dependent increase in the levels of osteopontin inhibits skeletal muscle regeneration
Paliwal, P., Pishesha, N., Wijaya, D., & Conboy, I. M. (2012) · Aging · doi:10.18632/aging.100477 · Cited by 89
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Sorted by citations
A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood
Rebo, J., Mehdipour, M., Gathwala, R., Causey, K., Liu, Y., Conboy, M. J., & Conboy, I. M. (2016) · Nature Communications · doi:10.1038/ncomms13363 · Cited by 291
Self-citationRejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin
Mehdipour, M., Skinner, C., Wong, N., Lieb, M., Liu, C., Etienne, J., Kato, C., Kiprov, D., Conboy, M. J., & Conboy, I. M. (2020) · Aging · doi:10.18632/aging.103418 · Cited by 115
Self-citationHeterochronic parabiosis regulates the extent of cellular senescence in multiple tissues
Yousefzadeh, M. J., Wilkinson, J. E., Hughes, B., Gadela, N., Ladiges, W. C., Vo, N., Niedernhofer, L. J., Huffman, D. M., & Robbins, P. D. (2020) · GeroScience · doi:10.1007/s11357-020-00185-1 · Cited by 70
Therapeutic Manipulation of Ageing: Repurposing Old Dogs and Discovering New Tricks
Mallikarjun, V., & Swift, J. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.11.020 · Cited by 14
Promises of reprogramming-induced rejuvenation
Simpson, D. J., Arif, N., Suwanlikit, Y., Kirschner, K., & Chandra, T. (2026) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2026.102484 · Cited by 2
Metadata
- Authors
- Conboy, I. M., Conboy, M. J., & Rebo, J.
- Affiliations
- Department of Bioengineering, UC Berkeley; QB3, CA 94709, USA
- Venue
- Aging
- Publisher
- Impact Journals, LLC
- Published
- 2015-10-25
- Volume
- 7
- Issue
- 10
- Pages
- 754-765
- ISSN
- 1945-4589
- PMC
- PMC4637204
- Cited by
- 58
- References
- 25
- Language
- en
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