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Cited by 25FOXO transcription factor regulationCancer-related Molecular PathwaysDNA Repair Mechanisms

CDK2 and FOXO1: A Fork in the Road for Cell Fate Decisions

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Huang, Haojie, Tindall, Donald J.·2007·Cell Cycle
DOI 10.4161/cc.6.8.4122
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Abstract

It has been well established that cyclin-dependent kinases (CDKs) including CDK2 and CDK1 play an essential role in mediating cell-cycle arrest, DNA repair and apoptosis in cells with damaged genomes. Following DNA damage, the function of CDKs is inhibited, and therefore cells are arrested at the G(1), S or G(2)/M phase of the cell-division cycle. It is believed that DNA damage-induced cell cycle arrest is important, because it allows cells to either repair the damage and survive or commit to apoptotic cell death. However, the molecular bases for the two cell fate options are not fully understood. Recently, we provided evidence that CDK2 interacts with and phosphorylates the forkhead transcription factor FOXO1. Importantly, activated CDK2 inhibits the pro-apoptotic function of FOXO1. However, in the presence of high levels of double-strand breaks (DSBs) the CDK2-mediated inhibition of FOXO1 is abrogated due to the ablation of CDK2 activity, and therefore the anti-apoptotic function of FOXO1 is restored. Thus, CDK2 silencing-dependent activation of FOXO1 represents a new mechanism that links DNA strand breakage to cell death.

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  • Consumption of a Western diet rich in Maillard reaction products correlates with impaired glucose metabolism, insulin resistance, and increased risk of cardiovascular and renal disease associated with metabolic syndrome and related conditions.

    “In fact, consumption of a Western diet rich in these products was found to correlate with impaired glucose metabolism, insulin resistance and increased risk of cardiovascular and renal disease associated with the metabolic syndrome and related conditions (449,450) .”

    From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [449]

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Cited by

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Related

Authors
Huang, H., & Tindall, D. J.
Affiliations
University of Minnesota (US)
ORCID
Huang, Haojie
Venue
Cell Cycle
Publisher
Informa UK Limited
Published
2007-04-15
Volume
6
Issue
8
Pages
902-906
ISSN
  • 1538-4101 (ISSN-L)
  • 1551-4005
DOI
10.4161/cc.6.8.4122
OpenAlex
W2008843624
Cited by
25
References
0
Citations by year
2024: 1 · 2023: 2 · 2022: 2 · 2020: 4 · 2019: 4 · 2017: 1 · 2016: 1 · 2014: 1 · 2013: 1 · 2012: 3
FWCI
0.40
Type
journal article
Language
en
Open access
Locations
  • Cell Cycle (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › FOXO transcription factor regulation
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Keywords
CDK2, FOXO1, cyclin-dependent kinases, DNA damage response, cell cycle arrest, apoptosis, DNA double-strand breaks, forkhead transcription factor, cell fate determination, DNA repair
MeSH terms
Forkhead Box Protein O1, Animals, DNA Damage, Humans, Models, Biological, Apoptosis, Genes, cdc, Cyclin-Dependent Kinase 2, Forkhead Transcription Factors

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