Cited by 311Gut microbiota and healthStress Responses and CortisolGastrointestinal motility and disorders

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Effects of intestinal microbiota on anxiety-like behavior

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Neufeld, Karen-Anne M., Kang, Nancy, Bienenstock, John, Foster, Jane A.·2011·Communicative & Integrative Biology

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Abstract

The acquisition of intestinal microbiota in the immediate postnatal period has a defining impact on the development and function of many immune and metabolic systems integral to health and well-being. Recent research has shown that the presence of gut microbiota regulates the set point for hypothalamic-pituitary-adrenal (HPA) axis activity.1 Accordingly, we sought to investigate if there were other changes of brain function such as behavioral alterations in germ free (GF) mice, and if so, to compare these to behavior of mice with normal gut microbiota. Our recent paper showed reduced anxietylike behavior in the elevated plus maze (EPM) in adult GF mice when compared to conventionally reared specific pathogen-free (SPF) mice.2 Here, we present data collected when we next colonized the adult GF mice with SPF feces thereby introducing normal gut microbiota, and then reassessed anxiety-like behavior. Interestingly, the anxiolytic behavioral phenotype observed in GF mice persisted after colonization with SPF intestinal microbiota. These data show that gut-brain interactions are important to CNS development of stress systems and that a critical window may exist after which reconstitution of microbiota and the immune system does not normalize the behavioral phenotype.

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Authors: Neufeld, K.-A. M., Kang, N., Bienenstock, J., & Foster, J. A.
Affiliations: McMaster University (CA)
St. Joseph’s Healthcare Hamilton (CA)
Corresponding author: Foster, Jane A.
ORCID: Neufeld, Karen-Anne M.
Bienenstock, John
Foster, Jane A.
Venue: Communicative & Integrative Biology
Publisher: Informa UK Limited
Published: 2011-07
Volume: 4
Issue: 4
Pages: 492-494
ISSN: 1942-0889 (ISSN-L)
DOI: 10.4161/cib.15702
PMC: PMC3181531
OpenAlex: W2137150469
Cited by: 311
References: 20
Citations by year: 2026: 12 · 2025: 12 · 2024: 21 · 2023: 20 · 2022: 28 · 2021: 37 · 2020: 25 · 2019: 34 · 2018: 24 · 2017: 27 · 2016: 19 · 2015: 26 · 2014: 10 · 2013: 12 · 2012: 4
FWCI: 3.38
Type: journal article
Language: en
Open access: gold
doi.org
Locations: Communicative & Integrative Biology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
PubMed
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: gut microbiota, anxiety-like behavior, germ-free mice, fecal microbiota transplantation, gut-brain axis, hypothalamic-pituitary-adrenal axis, stress response, central nervous system development

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Effects of intestinal microbiota on anxiety-like behavior

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